(Q28271436)

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Discovery of a Plasmodium falciparum glucose-6-phosphate dehydrogenase 6-phosphogluconolactonase inhibitor (R,Z)-N-((1-ethylpyrrolidin-2-yl)methyl)-2-(2-fluorobenzylidene)-3-oxo-3,4-dihydro-2H-benzo[b][1,4]thiazine-6-carboxamide (ML276) that reduces parasite growth in vitro (English)

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Plasmodium falciparum

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Layton H. Smith

object named as

Layton H Smith

18

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Anthony B Pinkerton

object named as

Anthony B Pinkerton

25

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24

object named as

Katja Becker

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author name string

Janina Preuss

1

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Patrick Maloney

2

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Satyamaheshwar Peddibhotla

3

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Michael P Hedrick

4

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Paul Hershberger

5

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Palak Gosalia

6

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Monika Milewski

7

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Yujie Linda Li

8

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Eliot Sugarman

9

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Becky Hood

10

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Eigo Suyama

11

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Kevin Nguyen

12

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Stefan Vasile

13

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Eduard Sergienko

14

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Arianna Mangravita-Novo

15

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Michael Vicchiarelli

16

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Danielle McAnally

17

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Gregory P Roth

19

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Jena Diwan

20

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Thomas D Y Chung

21

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Esther Jortzik

22

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Stefan Rahlfs

23

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Lars Bode

26

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language of work or name

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publication date

23 August 2012

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Journal of Medicinal Chemistry

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55

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16

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7262-72

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High-throughput screening for small-molecule inhibitors of plasmodium falciparum glucose-6-phosphate dehydrogenase 6-phosphogluconolactonase

1 reference

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Global malaria mortality between 1980 and 2010: a systematic analysis

1 reference

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Vaccines against malaria

1 reference

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Glucose-6-phosphate dehydrogenase-6-phosphogluconolactonase: a unique bifunctional enzyme from Plasmodium falciparum

1 reference

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Artemisinin Resistance in Plasmodium falciparum Malaria

1 reference

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1 reference

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Quantitative assessment of antimalarial activity in vitro by a semiautomated microdilution technique

1 reference

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Glucose-6-phosphate metabolism in Plasmodium falciparum

1 reference

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1 reference

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Artemisinin Resistance in Cambodia: A Clinical Trial Designed to Address an Emerging Problem in Southeast Asia

1 reference

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Plasmodium falciparum accompanied the human expansion out of Africa.

1 reference

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The malarial parasite Plasmodium falciparum imports the human protein peroxiredoxin 2 for peroxide detoxification

1 reference

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Molecular genetics and comparative genomics reveal RNAi is not functional in malaria parasites

1 reference

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The global prevalence of glucose-6-phosphate dehydrogenase deficiency: a systematic review and meta-analysis

1 reference

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Antimalarial drugs - what is in use and what is in the pipeline

1 reference

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Strategies to reverse drug resistance in malaria

1 reference

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Liquid-phase parallel synthesis of combinatorial libraries of substituted 6-carbamoyl-3,4-dihydro-2H-benzo[1,4]thiazines

1 reference

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Parasitological rebound effect and emergence of pyrimethamine resistance in Plasmodium falciparum after single-dose sulfadoxine-pyrimethamine

1 reference

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Modified fixed-ratio isobologram method for studying in vitro interactions between atovaquone and proguanil or dihydroartemisinin against drug-resistant strains of Plasmodium falciparum

1 reference

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The public health impact of chloroquine resistance in Africa

1 reference

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Early phagocytosis of glucose-6-phosphate dehydrogenase (G6PD)-deficient erythrocytes parasitized by Plasmodium falciparum may explain malaria protection in G6PD deficiency

1 reference

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Natural selection of hemi- and heterozygotes for G6PD deficiency in Africa by resistance to severe malaria

1 reference

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Chloroquine related cardiac toxicity

1 reference

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1 reference

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1 reference

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New hope in the fight against malaria?

1 reference

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Transient silencing of Plasmodium falciparum bifunctional glucose-6-phosphate dehydrogenase- 6-phosphogluconolactonase

1 reference

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Glucose-6-phosphate dehydrogenase-6-phosphogluconolactonase. A novel bifunctional enzyme in malaria parasites

1 reference

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1 reference

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Reversible conjugation of ethacrynic acid with glutathione and human glutathione S-transferase P1-1

1 reference

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Glucose 6-phosphate dehydrogenase deficiency: from genotype to phenotype

1 reference

https://pubmed.ncbi.nlm.nih.gov/22813531

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1021/JM300833H

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