(Q28275620)

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Synthetic and Receptor Signaling Explorations of the Mitragyna Alkaloids: Mitragynine as an Atypical Molecular Framework for Opioid Receptor Modulators

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Europe PubMed Central

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2 April 2020

Synthetic and Receptor Signaling Explorations of the Mitragyna Alkaloids: Mitragynine as an Atypical Molecular Framework for Opioid Receptor Modulators (English)

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2 April 2020

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Abhijeet Kapoor

3

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2 April 2020

4

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2 April 2020

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2 April 2020

Jonathan Javitch

7

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2 April 2020

Susruta Majumdar

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Susruta Majumdar

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2 April 2020

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Andrew C Kruegel

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2 April 2020

Madalee M Gassaway

2

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2 April 2020

Dalibor Sames

8

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2 April 2020

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18 May 2016

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2 April 2020

Journal of the American Chemical Society

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2 April 2020

138

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2 April 2020

21

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2 April 2020

6754-6764

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2 April 2020

The atypical antidepressant and neurorestorative agent tianeptine is a μ-opioid receptor agonist

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5189718

20 March 2017

Antagonists of the kappa opioid receptor

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5189718

20 March 2017

Crystal structure of the µ-opioid receptor bound to a morphinan antagonist

1 reference

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20 March 2017

Crystal structure of the β2 adrenergic receptor-Gs protein complex

1 reference

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20 March 2017

Crystal Structure of Arrestin-3 Reveals the Basis of the Difference in Receptor Binding Between Two Non-visual Subtypes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5189718

20 March 2017

Self-treatment of opioid withdrawal using kratom (Mitragynia speciosa korth)

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5189718

20 March 2017

The dysphoric component of stress is encoded by activation of the dynorphin kappa-opioid system

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5189718

20 March 2017

Crystal Structures of the Luciferase and Green Fluorescent Protein from Renilla reniformis

1 reference

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20 March 2017

Chemistry and pharmacology of analgesic indole alkaloids from the rubiaceous plant, Mitragyna speciosa

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5189718

20 March 2017

Antinociceptive effect of 7-hydroxymitragynine in mice: Discovery of an orally active opioid analgesic from the Thai medicinal herb Mitragyna speciosa

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5189718

20 March 2017

Crystal structure of venus, a yellow fluorescent protein with improved maturation and reduced environmental sensitivity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5189718

20 March 2017

Studies on the synthesis and opioid agonistic activities of mitragynine-related indole alkaloids: discovery of opioid agonists structurally different from other opioid ligands

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5189718

20 March 2017

AutoDock4 and AutoDockTools4: Automated docking with selective receptor flexibility

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5189718

7 April 2017

Structural insights into µ-opioid receptor activation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5189718

29 September 2017

Fulfilling the Promise of "Biased" G Protein-Coupled Receptor Agonism.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5189718

29 September 2017

The mixed-action delta/mu opioid agonist MMP-2200 does not produce conditioned place preference but does maintain drug self-administration in rats, and induces in vitro markers of tolerance and dependence

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5189718

29 September 2017

Mutation of three residues in the third intracellular loop of the dopamine D2 receptor creates an internalization-defective receptor

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5189718

29 September 2017

Safety, tolerability, and clinical effect of low-dose buprenorphine for treatment-resistant depression in midlife and older adults

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5189718

29 September 2017

Pharmacologic characterization in the rat of a potent analgesic lacking respiratory depression, IBNtxA.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5189718

29 September 2017

Mu opioids and their receptors: evolution of a concept

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5189718

29 September 2017

Orally active opioid compounds from a non-poppy source

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5189718

29 September 2017

A G protein-biased ligand at the μ-opioid receptor is potently analgesic with reduced gastrointestinal and respiratory dysfunction compared with morphine

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5189718

29 September 2017

Ligand-directed signalling within the opioid receptor family

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5189718

29 September 2017

Functional selectivity at the μ-opioid receptor: implications for understanding opioid analgesia and tolerance.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5189718

29 September 2017

Mitragyna speciosa, A Psychoactive Tree from Southeast Asia with Opioid Activity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5189718

29 September 2017

Spinal or systemic TY005, a peptidic opioid agonist/neurokinin 1 antagonist, attenuates pain with reduced tolerance.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5189718

29 September 2017

Antidepressant-like effect of mitragynine isolated from Mitragyna speciosa Korth in mice model of depression

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5189718

29 September 2017

Molecular insights into mu opioid pharmacology: From the clinic to the bench

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5189718

29 September 2017

kappa-Opioid receptor signaling and brain reward function

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5189718

29 September 2017

Phytochemical characterization of the leaves of Mitragyna speciosa grown in U.S.A.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5189718

29 September 2017

An opioid agonist that does not induce mu-opioid receptor--arrestin interactions or receptor internalization

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5189718

29 September 2017

Depressive symptoms during buprenorphine vs. methadone maintenance: findings from a randomised, controlled trial in opioid dependence

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5189718

29 September 2017

Antidepressant-like effects of kappa-opioid receptor antagonists in the forced swim test in rats

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5189718

29 September 2017

Clinical pharmacology of opioids for pain

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5189718

29 September 2017

Antidepressant-like effects of tramadol and other central analgesics with activity on monoamines reuptake, in helpless rats.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5189718

29 September 2017

Tramadol induces antidepressant-type effects in mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5189718

29 September 2017

Buprenorphine treatment of refractory depression

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5189718

29 September 2017

Possible antidepressive effects of opioids: action of buprenorphine

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5189718

29 September 2017

Biased agonism of the μ-opioid receptor by TRV130 increases analgesia and reduces on-target adverse effects versus morphine: A randomized, double-blind, placebo-controlled, crossover study in healthy volunteers

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5189718

2 June 2018

Orally active opioid μ/δ dual agonist MGM-16, a derivative of the indole alkaloid mitragynine, exhibits potent antiallodynic effect on neuropathic pain in mice.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5189718

2 June 2018

Antinociceptive effects of herkinorin, a MOP receptor agonist derived from salvinorin A in the formalin test in rats: new concepts in mu opioid receptor pharmacology: from a symposium on new concepts in mu-opioid pharmacology.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5189718

2 June 2018

Central antinociceptive effects of mitragynine in mice: contribution of descending noradrenergic and serotonergic systems

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5189718

2 June 2018

Effects of morphine, naloxone and their interaction in the learned-helplessness paradigm in rats.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5189718

2 June 2018

Treatment of refractory major depression with tramadol monotherapy.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5189718

27 November 2018

Antinociceptive action of mitragynine in mice: evidence for the involvement of supraspinal opioid receptors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5189718

27 November 2018

Some observations on the pharmacology of mitragynine

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5189718

27 November 2018

Treatment augmentation with opiates in severe and refractory major depression

1 reference

https://pubmed.ncbi.nlm.nih.gov/27192616

12 December 2020

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Open-label pilot study of tramadol hydrochloride in treatment-refractory obsessive-compulsive disorder

1 reference

https://pubmed.ncbi.nlm.nih.gov/27192616

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Total synthesis of ent-dihydrocorynantheol by using a proline-catalyzed asymmetric addition reaction

1 reference

https://pubmed.ncbi.nlm.nih.gov/27192616

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Antidepressant-like effect of endomorphin-1 and endomorphin-2 in mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/27192616

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A New Indole Alkaloid, 7 alpha-Hydroxy-7H-mitragynine, from Mitragyna speciosa in Thailand

1 reference

https://pubmed.ncbi.nlm.nih.gov/27192616

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Proline-catalyzed asymmetric addition reaction of 9-tosyl-3,4-dihydro-beta-carboline with ketones

1 reference

https://pubmed.ncbi.nlm.nih.gov/27192616

12 December 2020

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beta-Endorphin. Intravenous infusion causes behavioral change in psychiatric inpatients

1 reference

https://pubmed.ncbi.nlm.nih.gov/27192616

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

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10.1021/JACS.6B00360

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Europe PubMed Central

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2 April 2020

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2 April 2020

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27192616%20AND%20SRC:MED&resulttype=core&format=json

2 April 2020

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