(Q34488374)

2 August 2017

title

Structural insights into µ-opioid receptor activation (English)

1 reference

2 August 2017

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16

1 reference

2 August 2017

Evan N Feinberg

5

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Hideaki E. Kato

Hideaki E Kato

7

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William I Weis

William I Weis

15

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Stephen M. Husbands

Stephen M Husbands

13

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Peter Gmeiner

Peter Gmeiner

12

0 references

Brian Kobilka

18

Brian K Kobilka

1 reference

2 August 2017

2

Aashish Manglik

1 reference

2 August 2017

17

Ron O Dror

1 reference

2 August 2017

Weijiao Huang

1

1 reference

2 August 2017

A J Venkatakrishnan

3

1 reference

2 August 2017

Toon Laeremans

4

1 reference

2 August 2017

Adrian L Sanborn

6

1 reference

2 August 2017

Kathryn E Livingston

8

1 reference

2 August 2017

Thor S Thorsen

9

1 reference

2 August 2017

Ralf C Kling

10

1 reference

2 August 2017

Sébastien Granier

11

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2 August 2017

John R Traynor

14

1 reference

2 August 2017

language of work or name

English

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publication date

5 August 2015

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2 August 2017

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2 August 2017

volume

524

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2 August 2017

issue

7565

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2 August 2017

page(s)

315-321

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describes a project that uses

2 August 2017

1 reference

10 June 2022

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/efetch.fcgi?db=pmc&rettype=xml&id=4639397

exact match

https://scigraph.springernature.com/pub.10.1038/nature14886

0 references

cites work

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Structural Insights into the Dynamic Process of β2-Adrenergic Receptor Signaling

6 July 2018

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CHARMM-GUI Membrane Builder toward realistic biological membrane simulations

6 July 2018

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All-atom empirical potential for molecular modeling and dynamics studies of proteins

6 July 2018

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The 2.1 Å Resolution Structure of Cyanopindolol-Bound β1-Adrenoceptor Identifies an Intramembrane Na+ Ion that Stabilises the Ligand-Free Receptor

6 July 2018

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6 July 2018

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The role of protein dynamics in GPCR function: insights from the β2AR and rhodopsin

6 July 2018

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Molecular control of δ-opioid receptor signalling

6 July 2018

1 reference

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Activation and allosteric modulation of a muscarinic acetylcholine receptor

6 July 2018

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Mu opioids and their receptors: evolution of a concept

6 July 2018

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Adrenaline-activated structure of β2-adrenoceptor stabilized by an engineered nanobody

6 July 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4639397

The dynamic process of β(2)-adrenergic receptor activation

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4639397

Optimization of the additive CHARMM all-atom protein force field targeting improved sampling of the backbone φ, ψ and side-chain χ(1) and χ(2) dihedral angles

6 July 2018

1 reference

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High-resolution crystal structure of human protease-activated receptor 1

6 July 2018

1 reference

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Structural Basis for Allosteric Regulation of GPCRs by Sodium Ions

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4639397

Structure of the δ-opioid receptor bound to naltrindole

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4639397

Towards automated crystallographic structure refinement with phenix.refine

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4639397

Structure of the human κ-opioid receptor in complex with JDTic

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4639397

Crystal structure of the µ-opioid receptor bound to a morphinan antagonist

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4639397

Structure of the human M2 muscarinic acetylcholine receptor bound to an antagonist

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4639397

Crystal structure of the β2 adrenergic receptor-Gs protein complex

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4639397

Crystal structure of metarhodopsin II

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4639397

Structure and function of an irreversible agonist-β(2) adrenoceptor complex

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4639397

Structure of a nanobody-stabilized active state of the β(2) adrenoceptor

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4639397

Update of the CHARMM all-atom additive force field for lipids: validation on six lipid types

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4639397

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4639397

MolProbity: all-atom structure validation for macromolecular crystallography

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4639397

CHARMM general force field: A force field for drug-like molecules compatible with the CHARMM all-atom additive biological force fields

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4639397

Purification and functional reconstitution of monomeric mu-opioid receptors: allosteric modulation of agonist binding by Gi2.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4639397

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6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4639397

CHARMM: the biomolecular simulation program

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4639397

Crystallizing membrane proteins using lipidic mesophases

6 July 2018

1 reference

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Crystallizing membrane proteins for structure determination: use of lipidic mesophases

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4639397

Crystal structure of the ligand-free G-protein-coupled receptor opsin

6 July 2018

1 reference

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High-resolution crystal structure of an engineered human beta2-adrenergic G protein-coupled receptor

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4639397

GPCR engineering yields high-resolution structural insights into beta2-adrenergic receptor function

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4639397

Automated builder and database of protein/membrane complexes for molecular dynamics simulations

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4639397

A monomeric G protein-coupled receptor isolated in a high-density lipoprotein particle efficiently activates its G protein

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4639397

Probing the activation-promoted structural rearrangements in preassembled receptor-G protein complexes.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4639397

OPM: orientations of proteins in membranes database

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4639397

BU74, a complex oripavine derivative with potent kappa opioid receptor agonism and delayed opioid antagonism.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4639397

Coot: model-building tools for molecular graphics

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4639397

Characterization of the complex morphinan derivative BU72 as a high efficacy, long-lasting mu-opioid receptor agonist.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4639397

Extending the treatment of backbone energetics in protein force fields: limitations of gas-phase quantum mechanics in reproducing protein conformational distributions in molecular dynamics simulations

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4639397

Mu-opioid receptor desensitization by beta-arrestin-2 determines morphine tolerance but not dependence

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4639397

Crystal structure of rhodopsin: A G protein-coupled receptor

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4639397

mu Opioid receptor: role for the amino terminus as a determinant of ligand binding affinity

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4639397

Enhanced morphine analgesia in mice lacking beta-arrestin 2

6 July 2018

2 references

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4639397

6 July 2018

https://api.crossref.org/works/10.1038%2FNATURE14886

inferred from DOI database lookup

7 January 2021

based on heuristic

Loss of morphine-induced analgesia, reward effect and withdrawal symptoms in mice lacking the mu-opioid-receptor gene

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4639397

VMD: visual molecular dynamics

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4639397

A brief history of opiates, opioid peptides, and opioid receptors

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4639397

The kinetics of competitive radioligand binding predicted by the law of mass action.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4639397

The irreversible narcotic antagonistic and reversible agonistic properties of the fumaramate methyl ester derivative of naltrexone

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4639397

A ternary complex model explains the agonist-specific binding properties of the adenylate cyclase-coupled beta-adrenergic receptor

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4639397

Specific receptor for the opioid peptide dynorphin: structure--activity relationships

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4639397

Opiate agonists and antagonists discriminated by receptor binding in brain.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4639397

Morphine side effects in beta-arrestin 2 knockout mice

6 July 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE14886

Synthesis and in vitro opioid activity profiles of DALDA analogues

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE14886

Rhodopsin and 9-demethyl-retinal analog: effect of a partial agonist on displacement of transmembrane helix 6 in class A G protein-coupled receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE14886

CHARMM-GUI: a web-based graphical user interface for CHARMM

21 January 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/26245379

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Propagation of conformational changes during μ-opioid receptor activation

1 reference

https://api.crossref.org/works/10.1038%2FNATURE14886

inferred from DOI database lookup

7 January 2021

based on heuristic

Identifiers

DOI

10.1038/NATURE14886

1 reference

2 August 2017

1 reference

2 August 2017

1 reference