(Q24308061)

G protein-coupled acetylcholine receptor activity

GOA release 2020-03-11

1 reference

GOA release 2020-03-11

author

Jan Steyaert

14

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Els Pardon

8

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Aaron Ring

Aaron M Ring

2

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Celine Valant

Celine Valant

9

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William I Weis

William I Weis

15

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Peter Gmeiner

Peter Gmeiner

13

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Patrick M. Sexton

Patrick M Sexton

10

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Arthur Christopoulos

Arthur Christopoulos

11

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Brian Kobilka

18

Brian K Kobilka

0 references

Aashish Manglik

3

Aashish Manglik

0 references

Jürgen Wess

17

Jürgen Wess

0 references

author name string

Andrew C Kruse

1

0 references

Jianxin Hu

4

0 references

Kelly Hu

5

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Katrin Eitel

6

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Harald Hübner

7

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Christian C Felder

12

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K Christopher Garcia

Structure of the human M2 muscarinic acetylcholine receptor bound to an antagonist

16

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language of work or name

English

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publication date

5 December 2013

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published in

Nature

0 references

volume

504

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issue

7478

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page(s)

101-6

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cites work

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4020789

Crystal structure of the β2 adrenergic receptor-Gs protein complex

19 March 2017

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Structure of a nanobody-stabilized active state of the β(2) adrenoceptor

19 March 2017

1 reference

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Adrenaline-activated structure of β2-adrenoceptor stabilized by an engineered nanobody

19 March 2017

1 reference

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Structure and dynamics of the M3 muscarinic acetylcholine receptor

19 March 2017

1 reference

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Stabilized G protein binding site in the structure of constitutively active metarhodopsin-II

19 March 2017

1 reference

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Crystal structure of metarhodopsin II

19 March 2017

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Crystal structure of opsin in its G-protein-interacting conformation

19 March 2017

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Towards automated crystallographic structure refinement with phenix.refine

19 March 2017

1 reference

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Phasercrystallographic software

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4020789

Coot: model-building tools for molecular graphics

19 March 2017

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Role of conserved threonine and tyrosine residues in acetylcholine binding and muscarinic receptor activation. A study with m3 muscarinic receptor point mutants

19 March 2017

1 reference

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Crystallizing membrane proteins using lipidic mesophases

19 March 2017

1 reference

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Activation and dynamic network of the M2 muscarinic receptor

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4020789

The dynamic process of β(2)-adrenergic receptor activation

27 September 2017

1 reference

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The allosteric vestibule of a seven transmembrane helical receptor controls G-protein coupling

27 September 2017

1 reference

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A Monod-Wyman-Changeux mechanism can explain G protein-coupled receptor (GPCR) allosteric modulation

27 September 2017

1 reference

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Structural basis of M3 muscarinic receptor dimer/oligomer formation

27 September 2017

1 reference

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Allosteric modulation of G protein-coupled receptors: a pharmacological perspective.

27 September 2017

1 reference

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Allosteric activators of muscarinic receptors as novel approaches for treatment of CNS disorders

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4020789

Structural basis of G protein-coupled receptor-G protein interactions

27 September 2017

1 reference

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Identification of orthosteric and allosteric site mutations in M2 muscarinic acetylcholine receptors that contribute to ligand-selective signaling bias

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4020789

Allosteric ligands for G protein-coupled receptors: a novel strategy with attractive therapeutic opportunities

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4020789

Muscarinic acetylcholine receptors: mutant mice provide new insights for drug development

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4020789

Allosteric GPCR modulators: taking advantage of permissive receptor pharmacology.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4020789

A monomeric G protein-coupled receptor isolated in a high-density lipoprotein particle efficiently activates its G protein

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4020789

Structure/activity relationships of M2 muscarinic allosteric modulators

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4020789

Beta-lactamase inhibitors derived from single-domain antibody fragments elicited in the camelidae

27 September 2017

1 reference

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Activation of the beta 2-adrenergic receptor involves disruption of an ionic lock between the cytoplasmic ends of transmembrane segments 3 and 6.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4020789

Site-directed mutagenesis of the putative human muscarinic M2 receptor binding site

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4020789

High-throughput screening for drug discovery

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4020789

Identification of a receptor/G-protein contact site critical for signaling specificity and G-protein activation

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4020789

Purification of the muscarinic acetylcholine receptor from porcine atria

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4020789

The third intracellular loop stabilizes the inactive state of the neuropeptide Y1 receptor.

27 September 2017

1 reference

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A comparison of the action of acetylcholine and acetylcholine mustard (chloroethylmethylaminoethyl acetate) on muscarinic and nicotinic receptors

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4020789

Primary structure of porcine cardiac muscarinic acetylcholine receptor deduced from the cDNA sequence.

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4020789

Estimation of the affinities of allosteric ligands using radioligand binding and pharmacological null methods.

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4020789

Allosteric modulation of muscarinic acetylcholine receptors.

30 May 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE12735

Structure-function studies of allosteric agonism at M2 muscarinic acetylcholine receptors.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE12735

Probe dependence in the allosteric modulation of a G protein-coupled receptor: implications for detection and validation of allosteric ligand effects

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE12735

The structure of the third intracellular loop of the muscarinic acetylcholine receptor M2 subtype

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE12735

Rapid identification of functionally critical amino acids in a G protein-coupled receptor.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE12735

Acetylcholine mustard labels the binding site aspartate in muscarinic acetylcholine receptors.

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4020789

Convergent, short synthesis of the muscarinic superagonist iperoxo

29 November 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE12735

Allosteric interactions with muscarinic acetylcholine receptors: complex role of the conserved tryptophan M2422Trp in a critical cluster of amino acids for baseline affinity, subtype selectivity, and cooperativity

21 January 2018

1 reference

12 December 2020

Deletion analysis of the mouse m1 muscarinic acetylcholine receptor: effects on phosphoinositide metabolism and down-regulation

1 reference

12 December 2020

Processing of X-ray diffraction data collected in oscillation mode

1 reference

12 December 2020

Site-directed mutagenesis on the m2 muscarinic acetylcholine receptor: the significance of Tyr403 in the binding of agonists and functional coupling

1 reference

12 December 2020

Identifiers

DOI

10.1038/NATURE12735

1 reference

Dimensions Publication ID

499204

1037825045

0 references

499204

1 reference

1 reference

1 reference