(Q28276469)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27315480%20AND%20SRC:MED&resulttype=core&format=json

14 March 2020

title

The Extracellular Surface of the GLP-1 Receptor Is a Molecular Trigger for Biased Agonism (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27315480%20AND%20SRC:MED&resulttype=core&format=json

14 March 2020

1 reference

1

1 reference

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14 March 2020

Juan Carlos Mobarec

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27315480%20AND%20SRC:MED&resulttype=core&format=json

14 March 2020

John Simms

8

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27315480%20AND%20SRC:MED&resulttype=core&format=json

14 March 2020

Sebastian Furness

10

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27315480%20AND%20SRC:MED&resulttype=core&format=json

14 March 2020

M Liu

11

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27315480%20AND%20SRC:MED&resulttype=core&format=json

14 March 2020

Philip E. Thompson

12

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27315480%20AND%20SRC:MED&resulttype=core&format=json

14 March 2020

Arthur Christopoulos

14

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27315480%20AND%20SRC:MED&resulttype=core&format=json

14 March 2020

Patrick M. Sexton

15

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27315480%20AND%20SRC:MED&resulttype=core&format=json

14 March 2020

13

Laurence J Miller

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27315480%20AND%20SRC:MED&resulttype=core&format=json

14 March 2020

Christopher A. Reynolds

2

object named as

Christopher A Reynolds

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27315480%20AND%20SRC:MED&resulttype=core&format=json

14 March 2020

5

Cassandra Koole

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27315480%20AND%20SRC:MED&resulttype=core&format=json

14 March 2020

6

Emilia E Savage

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27315480%20AND%20SRC:MED&resulttype=core&format=json

14 March 2020

7

Kavita Pabreja

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27315480%20AND%20SRC:MED&resulttype=core&format=json

14 March 2020

9

Rohan Sridhar

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27315480%20AND%20SRC:MED&resulttype=core&format=json

14 March 2020

author name string

Kevin J Smith

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27315480%20AND%20SRC:MED&resulttype=core&format=json

14 March 2020

language of work or name

English

0 references

publication date

1 June 2016

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27315480%20AND%20SRC:MED&resulttype=core&format=json

14 March 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27315480%20AND%20SRC:MED&resulttype=core&format=json

14 March 2020

volume

165

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27315480%20AND%20SRC:MED&resulttype=core&format=json

14 March 2020

issue

7

1 reference

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14 March 2020

page(s)

1632-1643

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27315480%20AND%20SRC:MED&resulttype=core&format=json

A Hydrogen-Bonded Polar Network in the Core of the Glucagon-Like Peptide-1 Receptor Is a Fulcrum for Biased Agonism: Lessons from Class B Crystal Structures

14 March 2020

cites work

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4912689

Structure of class B GPCR corticotropin-releasing factor receptor 1

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4912689

Structure of the human glucagon class B G-protein-coupled receptor

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4912689

Molecular basis for negative regulation of the glucagon receptor

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4912689

Structure and mechanism for recognition of peptide hormones by Class B G-protein-coupled receptors

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4912689

How many drug targets are there?

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4912689

Genetically encoded chemical probes in cells reveal the binding path of urocortin-I to CRF class B GPCR

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4912689

The G-protein-coupled receptors in the human genome form five main families. Phylogenetic analysis, paralogon groups, and fingerprints

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4912689

Biology of incretins: GLP-1 and GIP

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4912689

Autocrine selection of a GLP-1R G-protein biased agonist with potent antidiabetic effects

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4912689

Polar transmembrane interactions drive formation of ligand-specific and signal pathway-biased family B G protein-coupled receptor conformations

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4912689

Signalling bias in new drug discovery: detection, quantification and therapeutic impact.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4912689

Structure-function of the G protein-coupled receptor superfamily

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4912689

Mapping spatial approximations between the amino terminus of secretin and each of the extracellular loops of its receptor using cysteine trapping

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4912689

Second extracellular loop of human glucagon-like peptide-1 receptor (GLP-1R) has a critical role in GLP-1 peptide binding and receptor activation

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4912689

The family B1 GPCR: structural aspects and interaction with accessory proteins

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4912689

Extracellular loops 1 and 3 and their associated transmembrane regions of the calcitonin receptor-like receptor are needed for CGRP receptor function

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4912689

Allosteric ligands of the glucagon-like peptide 1 receptor (GLP-1R) differentially modulate endogenous and exogenous peptide responses in a pathway-selective manner: implications for drug screening.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4912689

Comparative effects of the endogenous agonist glucagon-like peptide-1 (GLP-1)-(7-36) amide and the small-molecule ago-allosteric agent "compound 2" at the GLP-1 receptor

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4912689

A ternary complex model explains the agonist-specific binding properties of the adenylate cyclase-coupled beta-adrenergic receptor

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4912689

Structure-activity studies of glucagon-like peptide-1.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4912689

Operational models of pharmacological agonism.

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4912689

Differential activation and modulation of the glucagon-like peptide-1 receptor by small molecule ligands.

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4912689

Residues in the membrane-spanning and extracellular loop regions of the parathyroid hormone (PTH)-2 receptor determine signaling selectivity for PTH and PTH-related peptide

27 November 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/27315480

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1016/J.CELL.2016.05.023

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27315480%20AND%20SRC:MED&resulttype=core&format=json

14 March 2020

1 reference

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27315480%20AND%20SRC:MED&resulttype=core&format=json

14 March 2020

2 references