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CTLA-4 trafficking and surface expression
scientific article
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scholarly article
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Europe PubMed Central
title
CTLA-4 trafficking and surface expression
(English)
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author
Christopher E. Rudd
series ordinal
2
object named as
Christopher E Rudd
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author name string
Elke Valk
series ordinal
1
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Helga Schneider
series ordinal
3
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language of work or name
English
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publication date
June 2008
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published in
Trends in Immunology
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volume
29
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page(s)
272-9
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issue
6
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cites work
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Exocytosis of CTLA-4 is dependent on phospholipase D and ADP ribosylation factor-1 and stimulated during activation of regulatory T cells
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Interaction of the cytoplasmic tail of CTLA-4 (CD152) with a clathrin-associated protein is negatively regulated by tyrosine phosphorylation
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Interaction of CTLA-4 with the clathrin-associated protein AP50 results in ligand-independent endocytosis that limits cell surface expression
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CTLA-4 binding to the lipid kinase phosphatidylinositol 3-kinase in T cells
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Lymphoproliferative disorders with early lethality in mice deficient in Ctla-4
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Retrograde transport from endosomes to the trans-Golgi network
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Loss of CTLA-4 leads to massive lymphoproliferation and fatal multiorgan tissue destruction, revealing a critical negative regulatory role of CTLA-4
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29 September 2017
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TGF-beta requires CTLA-4 early after T cell activation to induce FoxP3 and generate adaptive CD4+CD25+ regulatory cells
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Cytotoxic T lymphocyte antigen-4 accumulation in the immunological synapse is regulated by TCR signal strength
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CTLA-4 in autoimmune diseases--a general susceptibility gene to autoimmunity?
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CTLA-4 gene polymorphism at position 49 in exon 1 reduces the inhibitory function of CTLA-4 and contributes to the pathogenesis of Graves' disease
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The CD28 and CTLA-4 receptors associate with the serine/threonine phosphatase PP2A.
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Augmentation of CTLA-4 expression by wortmannin: involvement of lysosomal sorting properties of CTLA-4.
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Defective CTLA-4 cycling pathway in Chediak-Higashi syndrome: a possible mechanism for deregulation of T lymphocyte activation
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Regulation of cytotoxic T lymphocyte-associated molecule-4 by Src kinases.
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29 September 2017
Engagement of cytotoxic T lymphocyte-associated antigen 4 (CTLA-4) induces transforming growth factor beta (TGF-beta) production by murine CD4(+) T cells
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29 September 2017
Synergistic induction of CTLA-4 expression by costimulation with TCR plus CD28 signals mediated by increased transcription and messenger ribonucleic acid stability
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29 September 2017
Regulation of CTLA-4 expression during T cell activation
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Characterization of CTLA-4 structure and expression on human T cells.
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29 September 2017
Cytotoxic T lymphocyte antigen 4 and CD28 modulate cell surface raft expression in their regulation of T cell function
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2 June 2018
Cytotoxic T lymphocyte antigen 4 is induced in the thymus upon in vivo activation and its blockade prevents anti-CD3-mediated depletion of thymocytes
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2 June 2018
CD28 receptor endocytosis is targeted by mutations that disrupt phosphatidylinositol 3-kinase binding and costimulation.
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2 June 2018
The emerging role of CTLA-4 as an immune attenuator
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2 June 2018
Phosphatidylinositol 3-kinase activity is required at a postendocytic step in platelet-derived growth factor receptor trafficking
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2 June 2018
Cytotoxic T lymphocyte-associated molecule-4, a high-avidity receptor for CD80 and CD86, contains an intracellular localization motif in its cytoplasmic tail
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Differential inhibition of autoreactive memory- and alloreactive naive T cell responses by soluble cytotoxic T lymphocyte antigen 4 (sCTLA4), CTLA4Ig and LEA29Y
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27 November 2018
Enhanced engagement of CTLA-4 induces antigen-specific CD4+CD25+Foxp3+ and CD4+CD25- TGF-beta 1+ adaptive regulatory T cells
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27 November 2018
T cell receptor-interacting molecule acts as a chaperone to modulate surface expression of the CTLA-4 coreceptor.
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27 November 2018
Regulation of indoleamine 2,3-dioxygenase and tryptophanyl-tRNA-synthetase by CTLA-4-Fc in human CD4+ T cells.
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27 November 2018
B7-1 and B7-2 selectively recruit CTLA-4 and CD28 to the immunological synapse
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27 November 2018
Differential expression of CTLA-4 among T cell subsets.
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27 November 2018
Modulation of tryptophan catabolism by regulatory T cells.
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27 November 2018
Diversity of clonal T cell proliferation is mediated by differential expression of CD152 (CTLA-4) on the cell surface of activated individual T lymphocytes.
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27 November 2018
A common autoimmunity predisposing signal peptide variant of the cytotoxic T-lymphocyte antigen 4 results in inefficient glycosylation of the susceptibility allele
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27 November 2018
Reduced CTLA-4 protein and messenger RNA expression in umbilical cord blood T lymphocytes.
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27 November 2018
A polymorphism in the human cytotoxic T-lymphocyte antigen 4 ( CTLA4) gene (exon 1 +49) alters T-cell activation
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27 November 2018
Regulation of surface and intracellular expression of CTLA-4 on human peripheral T cells
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27 November 2018
Regulation of cell surface expression of CTLA-4 by secretion of CTLA-4-containing lysosomes upon activation of CD4+ T cells
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27 November 2018
Complete sequence determination of the mouse and human CTLA4 gene loci: cross-species DNA sequence similarity beyond exon borders.
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27 November 2018
Cytolytic T lymphocyte-associated antigen-4 and the TCR zeta/CD3 complex, but not CD28, interact with clathrin adaptor complexes AP-1 and AP-2
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27 November 2018
CTLA-4 ligation suppresses CD28-induced NF-kappaB and AP-1 activity in mouse T cell blasts
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27 November 2018
CTLA4 ligation attenuates AP-1, NFAT and NF-kappaB activity in activated T cells
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27 November 2018
Lymphoproliferation in CTLA-4-deficient mice is mediated by costimulation-dependent activation of CD4+ T cells
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27 November 2018
Tyrosine phosphorylation controls internalization of CTLA-4 by regulating its interaction with clathrin-associated adaptor complex AP-2
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4186961
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27 November 2018
Regulation of surface and intracellular expression of CTLA4 on mouse T cells
1 reference
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PubMed Central
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retrieved
27 November 2018
Intracellular trafficking of CTLA-4 and focal localization towards sites of TCR engagement
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4186961
retrieved
27 November 2018
Regulation of T cell receptor signaling by tyrosine phosphatase SYP association with CTLA-4
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4186961
retrieved
27 November 2018
Identifiers
DOI
10.1016/J.IT.2008.02.011
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PMCID
4186961
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PubMed ID
18468488
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