(Q28281865)

English

Impaired de novo choline synthesis explains why phosphatidylethanolamine N-methyltransferase-deficient mice are protected from diet-induced obesity

scientific article

In more languages

Statements

scholarly article

0 references

Impaired de novo choline synthesis explains why phosphatidylethanolamine N-methyltransferase-deficient mice are protected from diet-induced obesity (English)

0 references

0 references

0 references

René L. Jacobs

object named as

René L Jacobs

1

0 references

Spencer Proctor

object named as

Spencer D Proctor

10

0 references

author name string

Yang Zhao

2

0 references

Debby P Y Koonen

3

0 references

Torunn Sletten

4

0 references

Brian Su

5

0 references

Susanne Lingrell

6

0 references

Guoqing Cao

7

0 references

David A Peake

8

0 references

Ming-Shang Kuo

9

0 references

Brian P Kennedy

11

0 references

Jason R B Dyck

12

0 references

Dennis E Vance

13

0 references

language of work or name

0 references

publication date

16 July 2010

0 references

Journal of Biological Chemistry

0 references

285

0 references

29

0 references

22403-13

0 references

describes a project that uses

1 reference

Europe PubMed Central

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC2903412/fullTextXML

based on heuristic

inferred from PubMed Central ID database lookup

Lack of phosphatidylethanolamine N-methyltransferase alters plasma VLDL phospholipids and attenuates atherosclerosis in mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2903412

20 March 2017

AGPAT6 is a novel microsomal glycerol-3-phosphate acyltransferase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2903412

20 March 2017

Hepatic phosphatidylethanolamine N-methyltransferase, unexpected roles in animal biochemistry and physiology

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2903412

20 March 2017

Inhibition of sphingomyelin synthase (SMS) affects intracellular sphingomyelin accumulation and plasma membrane lipid organization

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2903412

20 March 2017

Common genetic polymorphisms affect the human requirement for the nutrient choline

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2903412

20 March 2017

Polymorphism of the PEMT gene and susceptibility to nonalcoholic fatty liver disease (NAFLD)

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2903412

20 March 2017

An unexpected requirement for phosphatidylethanolamine N-methyltransferase in the secretion of very low density lipoproteins

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2903412

20 March 2017

Molecular distinction of phosphatidylcholine synthesis between the CDP-choline pathway and phosphatidylethanolamine methylation pathway

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2903412

20 March 2017

The active synthesis of phosphatidylcholine is required for very low density lipoprotein secretion from rat hepatocytes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2903412

20 March 2017

Choline, an essential nutrient for humans

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2903412

20 March 2017

Mice deleted for fatty acid transport protein 5 have defective bile acid conjugation and are protected from obesity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2903412

20 March 2017

Malonyl coenzyme a decarboxylase inhibition protects the ischemic heart by inhibiting fatty acid oxidation and stimulating glucose oxidation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2903412

20 March 2017

Adipose overexpression of desnutrin promotes fatty acid use and attenuates diet-induced obesity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2903412

29 September 2017

Mechanisms of hepatic steatosis in mice fed a lipogenic methionine choline-deficient diet

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2903412

29 September 2017

Hepatic NF-kappa B essential modulator deficiency prevents obesity-induced insulin resistance but synergizes with high-fat feeding in tumorigenesis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2903412

29 September 2017

Involvement of AMP-activated protein kinase in beneficial effects of betaine on high-sucrose diet-induced hepatic steatosis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2903412

29 September 2017

Betaine supplementation improves the atherogenic risk factor profile in a transgenic mouse model of hyperhomocysteinemia

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2903412

29 September 2017

Obesity-related derangements in metabolic regulation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2903412

29 September 2017

Betaine: a key modulator of one-carbon metabolism and homocysteine status

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2903412

29 September 2017

Antisense oligonucleotide reduction of DGAT2 expression improves hepatic steatosis and hyperlipidemia in obese mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2903412

29 September 2017

Hepatocyte CYP2E1 overexpression and steatohepatitis lead to impaired hepatic insulin signaling.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2903412

29 September 2017

A gender-specific role for phosphatidylethanolamine N-methyltransferase-derived phosphatidylcholine in the regulation of plasma high density and very low density lipoproteins in mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2903412

29 September 2017

Role for stearoyl-CoA desaturase-1 in leptin-mediated weight loss

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2903412

29 September 2017

Disruption of the murine gene encoding phosphatidylethanolamine N-methyltransferase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2903412

29 September 2017

The structure of the gene for murine CTP:phosphocholine cytidylyltransferase, Ctpct. Relationship of exon structure to functional domains and identification of transcriptional start sites and potential upstream regulatory elements

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2903412

29 September 2017

Gas chromatographic analysis of plasma lipids

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2903412

29 September 2017

Brain Acetylcholine: Control by Dietary Choline

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2903412

29 September 2017

An afferent vagal nerve pathway links hepatic PPARalpha activation to glucocorticoid-induced insulin resistance and hypertension

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2903412

2 June 2018

The methionine-choline deficient dietary model of steatohepatitis does not exhibit insulin resistance

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2903412

2 June 2018

LXRs regulate the balance between fat storage and oxidation.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110.108514

21 January 2018

Targeted deletion of AIF decreases mitochondrial oxidative phosphorylation and protects from obesity and diabetes

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110.108514

21 January 2018

Hepatic expression of malonyl-CoA decarboxylase reverses muscle, liver and whole-animal insulin resistance

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110.108514

21 January 2018

Gene structure, expression and identification of a new CTP:phosphocholine cytidylyltransferase beta isoform.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110.108514

21 January 2018

A role for hepatic scavenger receptor class B, type I in decreasing high density lipoprotein levels in mice that lack phosphatidylethanolamine N-methyltransferase

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110.108514

21 January 2018

Mice fed a lipogenic methionine-choline-deficient diet develop hypermetabolism coincident with hepatic suppression of SCD-1.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110.108514

21 January 2018

Stearoyl-CoA desaturase 1 deficiency increases CTP:choline cytidylyltransferase translocation into the membrane and enhances phosphatidylcholine synthesis in liver

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110.108514

21 January 2018

Hepatic CTP:phosphocholine cytidylyltransferase-alpha is a critical predictor of plasma high density lipoprotein and very low density lipoprotein

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110.108514

21 January 2018

High-throughput quantification of phosphatidylcholine and sphingomyelin by electrospray ionization tandem mass spectrometry coupled with isotope correction algorithm

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110.108514

21 January 2018

Targeted deletion of hepatic CTP:phosphocholine cytidylyltransferase alpha in mice decreases plasma high density and very low density lipoproteins.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110.108514

21 January 2018

Physiological regulation of phospholipid methylation alters plasma homocysteine in mice.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110.108514

21 January 2018

High sodium chloride intake decreases betaine-homocysteine S-methyltransferase expression in guinea pig liver and kidney

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110.108514

21 January 2018

Choline metabolism and phosphatidylcholine biosynthesis in cultured rat hepatocytes

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110.108514

21 January 2018

Alleviation of acute ethanol-induced liver injury and impaired metabolomics of S-containing substances by betaine supplementation

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110.108514

21 January 2018

Betaine, a promising new agent for patients with nonalcoholic steatohepatitis: results of a pilot study

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110.108514

21 January 2018

Dissociation of Hepatic Steatosis and Insulin Resistance in Mice Overexpressing DGAT in the Liver

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110.108514

21 January 2018

A choline-deficient diet exacerbates fatty liver but attenuates insulin resistance and glucose intolerance in mice fed a high-fat diet.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110.108514

21 January 2018

Regulation of free choline in rat brain: dietary and pharmacological manipulations

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110.108514

21 January 2018

Choline availability and acetylcholine synthesis in the hippocampus of acetylcholinesterase-deficient mice

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110.108514

21 January 2018

Beneficial metabolic effects of M3 muscarinic acetylcholine receptor deficiency

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110.108514

21 January 2018

Choline, CDP-choline or phosphocholine increases plasma glucagon in rats: involvement of the peripheral autonomic nervous system.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110.108514

21 January 2018

Choline increases serum insulin in rat when injected intraperitoneally and augments basal and stimulated aceylcholine release from the rat minced pancreas in vitro

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110.108514

21 January 2018

Acetylcholine release and choline availability in rat hippocampus: effects of exogenous choline and nicotinamide

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2903412

27 November 2018

Choline deficiency: a cause of hepatic steatosis during parenteral nutrition that can be reversed with intravenous choline supplementation

1 reference

https://pubmed.ncbi.nlm.nih.gov/20452975

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The unique acyl chain specificity of biliary phosphatidylcholines in mice is independent of their biosynthetic origin in the liver

1 reference

https://pubmed.ncbi.nlm.nih.gov/20452975

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Divergent associations of plasma choline and betaine with components of metabolic syndrome in middle age and elderly men and women

1 reference

https://pubmed.ncbi.nlm.nih.gov/20452975

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Neuronal pathway from the liver modulates energy expenditure and systemic insulin sensitivity

1 reference

https://pubmed.ncbi.nlm.nih.gov/20452975

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Intrahepatic insulin resistance in a murine model of steatohepatitis: effect of PPARgamma agonist pioglitazone

1 reference

https://pubmed.ncbi.nlm.nih.gov/20452975

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The phosphatidylethanolamine N-methyltransferase pathway is quantitatively not essential for biliary phosphatidylcholine secretion

1 reference

https://pubmed.ncbi.nlm.nih.gov/20452975

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Essential pathogenic and metabolic differences in steatosis induced by choline or methione-choline deficient diets in a rat model

1 reference

https://pubmed.ncbi.nlm.nih.gov/20452975

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

Sitelinks

Wikipedia(0 entries)

Wikibooks(0 entries)

Wikinews(0 entries)

Wikiquote(0 entries)

Wikisource(0 entries)

Wikiversity(0 entries)

Wikivoyage(0 entries)

Wiktionary(0 entries)

Multilingual sites(0 entries)

Retrieved from "https://www.wikidata.org/w/index.php?title=Q28281865&oldid=1659336156"