(Q28303826)

1

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Mark Bures

2

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Michael P Johnson

3

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James A Monn

5

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Darryle D Schoepp

Nature Reviews Drug Discovery

6

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language of work or name

English

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publication date

February 2005

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published in

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volume

4

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issue

2

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page(s)

131-44

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cites work

Regulation of neurotransmitter release by metabotropic glutamate receptors

1 reference

Distribution of metabotropic glutamate receptor mGluR3 in the mouse CNS: differential location relative to pre- and postsynaptic sites

21 April 2017

1 reference

Reversal of phencyclidine effects by a group II metabotropic glutamate receptor agonist in rats

21 April 2017

1 reference

Independent assembly and subcellular targeting of GABA(A)-receptor subtypes demonstrated in mouse hippocampal and olfactory neurons in vivo

21 April 2017

1 reference

2-Methyl-6-(phenylethynyl)-pyridine (MPEP), a potent, selective and systemically active mGlu5 receptor antagonist

21 April 2017

1 reference

Modulation of GABAergic signaling among interneurons by metabotropic glutamate receptors

21 April 2017

1 reference

Antidepressant and anxiolytic-like effects in mice lacking the group III metabotropic glutamate receptor mGluR7

21 April 2017

1 reference

Potential anti-anxiety, anti-addictive effects of LY 354740, a selective group II glutamate metabotropic receptors agonist in animal models

21 April 2017

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21 April 2017

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Structural basis of glutamate recognition by a dimeric metabotropic glutamate receptor

21 April 2017

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Pharmacology and functions of metabotropic glutamate receptors

21 April 2017

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Animal models sensitive to anti-anxiety agents

21 April 2017

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Summary of a National Institute of Mental Health workshop: developing animal models of anxiety disorders.

31 March 2020

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Anxioselective compounds acting at the GABA(A) receptor benzodiazepine binding site

31 March 2020

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Noradrenaline in mood and anxiety disorders: basic and clinical studies.

31 March 2020

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Non-peptidic CRF1 receptor antagonists for the treatment of anxiety, depression and stress disorders

31 March 2020

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Neuropeptide systems as novel therapeutic targets for depression and anxiety disorders

31 March 2020

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Role of selective serotonin reuptake inhibitors in psychiatric disorders: a comprehensive review

31 March 2020

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Modulation of NMDA receptors by glycine ? introduction to some basic aspects and recent developments

31 March 2020

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Novel functions for subtypes of metabotropic glutamate receptors.

31 March 2020

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Metabotropic glutamate receptors: synaptic transmission, modulation, and plasticity.

31 March 2020

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The metabotropic glutamate receptors: structure, activation mechanism and pharmacology

31 March 2020

1 reference

A role for noradrenergic transmission in the actions of phencyclidine and the antipsychotic and antistress effects of mGlu2/3 receptor agonists

31 March 2020

1 reference

LY354740, an mGlu2/3 receptor agonist as a novel approach to treat anxiety/stress

31 March 2020

1 reference

The role of the amygdala in fear and anxiety

31 March 2020

1 reference

Distribution of the messenger RNA for a metabotropic glutamate receptor, mGluR2, in the central nervous system of the rat.

31 March 2020

1 reference

Distribution of the mRNA for a metabotropic glutamate receptor (mGluR3) in the rat brain: an in situ hybridization study

31 March 2020

1 reference

The metabotropic glutamate receptors, mGluR2 and mGluR3, show unique postsynaptic, presynaptic and glial localizations

31 March 2020

1 reference

Metabotropic glutamate receptors: electrophysiological properties and role in plasticity

31 March 2020

1 reference

The role of amygdala glutamate receptors in fear learning, fear-potentiated startle, and extinction

31 March 2020

1 reference

Involvement of subcortical and cortical afferents to the lateral nucleus of the amygdala in fear conditioning measured with fear-potentiated startle in rats trained concurrently with auditory and visual conditioned stimuli.

31 March 2020

1 reference

Trans-ACPD and L-APB presynaptically inhibit excitatory glutamatergic transmission in the basolateral amygdala (BLA).

31 March 2020

1 reference

Validation of open:closed arm entries in an elevated plus-maze as a measure of anxiety in the rat

31 March 2020

1 reference

Design, synthesis, and pharmacological characterization of (+)-2-aminobicyclo[3.1.0]hexane-2,6-dicarboxylic acid (LY354740): a potent, selective, and orally active group 2 metabotropic glutamate receptor agonist possessing anticonvulsant and anxioly

31 March 2020

1 reference

Interactions between LY354740, a group II metabotropic agonist and the GABA(A)-benzodiazepine receptor complex in the rat elevated plus-maze

31 March 2020

1 reference

Pharmacological profile of a potential anxiolytic: AP159, a new benzothieno-pyridine derivative

31 March 2020

1 reference

Neuropharmacology of a new potential anxiolytic compound, F 2692, 1-(3'-trifluoromethyl phenyl) 1,4-dihydro 3-amino 4-oxo 6-methyl pyridazine. 1. Acute and in vitro effects.

31 March 2020

1 reference

LY354740, a potent group II metabotropic glutamate receptor agonist prevents lactate-induced panic-like response in panic-prone rats.

31 March 2020

1 reference

Anxiolytic activity of the MGLU2/3 receptor agonist LY354740 on the elevated plus maze is associated with the suppression of stress-induced c-Fos in the hippocampus and increases in c-Fos induction in several other stress-sensitive brain regions.

31 March 2020

1 reference

Conditioned fear-induced changes in behavior and in the expression of the immediate early gene c-fos: with and without diazepam pretreatment.

31 March 2020

1 reference

Expression of Fos protein in various rat brain areas following acute nicotine and diazepam.

31 March 2020

1 reference

Differential sensitivity of c-Fos expression in hippocampus and other brain regions to moderate and low doses of alcohol.

31 March 2020

1 reference

Intrinsic GABAergic neurons in the rat central extended amygdala.

31 March 2020

1 reference

Evidence for a GABAergic interface between cortical afferents and brainstem projection neurons in the rat central extended amygdala.

31 March 2020

1 reference

Intrinsic and extrinsic connections of the rat central extended amygdala: an in vivo electrophysiological study of the central amygdaloid nucleus.

31 March 2020

1 reference

Drug interactions at the GABA receptor-ionophore complex

31 March 2020

1 reference

Pharmacological manipulation of mGlu2 receptors influences cognitive performance in the rodent

31 March 2020

1 reference

A new benzodiazepine pharmacology.

31 March 2020

1 reference

Molecular and neuronal substrate for the selective attenuation of anxiety.

31 March 2020

1 reference

Differential synaptic localization of two major gamma-aminobutyric acid type A receptor alpha subunits on hippocampal pyramidal cells

31 March 2020

1 reference

GABA(A) receptor subtypes: dissecting their pharmacological functions

31 March 2020

1 reference

SAR study of a subtype selective allosteric potentiator of metabotropic glutamate 2 receptor, N-(4-phenoxyphenyl)-N-(3-pyridinylmethyl)ethanesulfonamide

31 March 2020

1 reference

Discovery of allosteric potentiators for the metabotropic glutamate 2 receptor: synthesis and subtype selectivity of N-(4-(2-methoxyphenoxy)phenyl)-N-(2,2,2- trifluoroethylsulfonyl)pyrid-3-ylmethylamine

31 March 2020

1 reference

Pharmacological characterization and identification of amino acids involved in the positive modulation of metabotropic glutamate receptor subtype 2.

31 March 2020

1 reference

Distribution of metabotropic glutamate receptor mGluR5 immunoreactivity in rat brain

31 March 2020

1 reference

Differential plasma membrane distribution of metabotropic glutamate receptors mGluR1 alpha, mGluR2 and mGluR5, relative to neurotransmitter release sites

31 March 2020

1 reference

Distribution of mGluR1alpha and mGluR5 immunolabeling in primate prefrontal cortex

31 March 2020

1 reference

Differential localization of phosphoinositide-linked metabotropic glutamate receptor (mGluR1) and the inositol 1,4,5-trisphosphate receptor in rat brain.

31 March 2020

1 reference

Presynaptic mGlu1 type receptors potentiate transmitter output in the rat cortex

31 March 2020

1 reference

Activation of metabotropic glutamate receptor 5 has direct excitatory effects and potentiates NMDA receptor currents in neurons of the subthalamic nucleus.

31 March 2020

1 reference

Repeated cocaine administration attenuates group I metabotropic glutamate receptor-mediated glutamate release and behavioral activation: a potential role for Homer.

31 March 2020

1 reference

Pharmacological analysis of 4-carboxyphenylglycine derivatives: comparison of effects on mGluR1 alpha and mGluR5a subtypes

31 March 2020

1 reference

The anxiolytic-like effect of metabotropic glutamate receptor antagonists after intrahippocampal injection in rats.

31 March 2020

1 reference

Metabotropic glutamate receptor mRNA expression in the basal ganglia of the rat.

31 March 2020

1 reference

Microinjections of the metabotropic glutamate receptor agonist, trans-(+/-)-1-amino-cyclopentane-1,3-dicarboxylate (trans-ACPD) into the amygdala increase the acoustic startle response of rats.

31 March 2020

1 reference

The antianxiety-like effects of antagonists of group I and agonists of group II and III metabotropic glutamate receptors after intrahippocampal administration

31 March 2020

1 reference

Effects of the prototypical mGlu(5) receptor antagonist 2-methyl-6-(phenylethynyl)-pyridine on rotarod, locomotor activity and rotational responses in unilateral 6-OHDA-lesioned rats

31 March 2020

1 reference

Potential anxiolytic- and antidepressant-like effects of MPEP, a potent, selective and systemically active mGlu5 receptor antagonist

31 March 2020

1 reference

Pharmacological and endocrinological characterisation of stress-induced hyperthermia in singly housed mice using classical and candidate anxiolytics (LY314582, MPEP and NKP608).

31 March 2020

1 reference

Changes in rat serum corticosterone after treatment with metabotropic glutamate receptor agonists or antagonists

31 March 2020

1 reference

Corticotropin-releasing factor: effects on the sympathetic nervous system and oxygen consumption

31 March 2020

1 reference

Fear conditioning-induced time- and subregion-specific increase in expression of mGlu5 receptor protein in rat hippocampus.

31 March 2020

1 reference

The metabotropic glutamate receptor antagonist 2-methyl-6-(phenylethynyl)-pyridine (MPEP) blocks fear conditioning in rats

31 March 2020

1 reference

A theory of hippocampal function in memory.

31 March 2020

1 reference

The group I metabotropic glutamate receptor mGluR5 is required for fear memory formation and long-term potentiation in the lateral amygdala.

31 March 2020

1 reference

Long-lasting potentiation of synaptic transmission in the dentate area of the anaesthetized rabbit following stimulation of the perforant path

31 March 2020

1 reference

Synaptic plasticity: LTP and LTD.

31 March 2020

1 reference

2-Amino-3-phosphonopropionate blocks the induction and maintenance of long-term potentiation in rat hippocampal slices

31 March 2020

1 reference

Co-activation of metabotropic glutamate and N-methyl-D-aspartate receptors is involved in mechanisms of long-term potentiation maintenance in rat hippocampal CA1 neurons.

31 March 2020

1 reference

Inhibition of long-term potentiation in the dentate gyrus of freely moving rats by the metabotropic glutamate receptor antagonist MCPG

31 March 2020

1 reference

When are class I metabotropic glutamate receptors necessary for long-term potentiation?

31 March 2020

1 reference

Potentiation of NMDA and AMPA responses by the specific mGluR5 agonist CHPG in spinal cord motoneurons

31 March 2020

1 reference

Class I mGlu receptor antagonist 1-aminoindan-1,5-dicarboxylic acid blocks contextual but not cue conditioning in rats.

31 March 2020

1 reference

Enhanced N-methyl-D-aspartate function reverses working memory failure induced by blockade of group I metabotropic glutamate receptors in the rat hippocampus.

31 March 2020

1 reference

Modulation of multiple potassium currents by metabotropic glutamate receptors in neurons of the hypothalamic supraoptic nucleus.

31 March 2020

1 reference

Presynaptic modulation by metabotropic glutamate receptors of excitatory and inhibitory synaptic inputs to hypothalamic magnocellular neurons

31 March 2020

1 reference

Effects of dofetilide on cardiovascular tissues from normo- and hypertensive rats

31 March 2020

1 reference

Metabotropic glutamate receptor subtype 7 ablation causes deficit in fear response and conditioned taste aversion

31 March 2020

1 reference

Increased anxiety-related behavior in mice deficient for metabotropic glutamate 8 (mGlu8) receptor

31 March 2020

1 reference

Measuring normal and pathological anxiety-like behaviour in mice: a review.

31 March 2020

1 reference

Presynaptic inhibitory action of the group II metabotropic glutamate receptor agonists, LY354740 and DCG-IV.

31 March 2020

1 reference

Groups II and III metabotropic glutamate receptors differentially modulate brief and prolonged nociception in primate STT cells.

31 March 2020

1 reference

The anxiolytic action of mGlu2/3 receptor agonist, LY354740, in the fear-potentiated startle model in rats is mechanistically distinct from diazepam

31 March 2020

1 reference

Systemic administration of the potent mGlu8 receptor agonist (S)-3,4-DCPG induces c-Fos in stress-related brain regions in wild-type, but not mGlu8 receptor knockout mice

31 March 2020

1 reference

Anxiolytic effects of a novel group II metabotropic glutamate receptor agonist (LY354740) in the fear-potentiated startle paradigm in humans

31 March 2020

1 reference

Effects of the group II metabotropic glutamate receptor agonist, LY354740 on schedule-controlled behaviour in rats.

31 March 2020

1 reference

The mGlu2/3 receptor agonist, LY354740, blocks immobilization-induced increases in noradrenaline and dopamine release in the rat medial prefrontal cortex.

31 March 2020

1 reference

Synthesis of the four isomers of 4-aminopyrrolidine-2,4-dicarboxylate: identification of a potent, highly selective, and systemically-active agonist for metabotropic glutamate receptors negatively coupled to adenylate cyclase.

31 March 2020

1 reference

Synthesis and pharmacological characterization of aminocyclopentanetricarboxylic acids: new tools to discriminate between metabotropic glutamate receptor subtypes

31 March 2020

1 reference

Synthesis and metabotropic glutamate receptor activity of a 2-aminobicyclo[3.2.0]heptane-2,5-dicarboxylic acid, a molecule possessing an extended glutamate conformation

31 March 2020

1 reference

LY354740 is a potent and highly selective group II metabotropic glutamate receptor agonist in cells expressing human glutamate receptors

31 March 2020

1 reference

The non-competitive antagonists 2-methyl-6-(phenylethynyl)pyridine and 7-hydroxyiminocyclopropan[b]chromen-1a-carboxylic acid ethyl ester interact with overlapping binding pockets in the transmembrane region of group I metabotropic glutamate recepto

31 March 2020

1 reference

Mutational Analysis and Molecular Modeling of the Binding Pocket of the Metabotropic Glutamate 5 Receptor Negative Modulator 2-Methyl-6-(phenylethynyl)-pyridine

31 March 2020

1 reference

Behavioral pharmacology of N-methyl-D-aspartate antagonists: implications for the study and pharmacotherapy of anxiety and schizophrenia.

31 March 2020

1 reference

inferred from DOI database lookup

7 January 2021

based on heuristic

Group II metabotropic glutamate receptors within the amygdala regulate fear as assessed with potentiated startle in rats.

1 reference