(Q28304920)

English

DNA damage response mediators MDC1 and 53BP1: constitutive activation and aberrant loss in breast and lung cancer, but not in testicular germ cell tumours

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scholarly article

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DNA damage response mediators MDC1 and 53BP1: constitutive activation and aberrant loss in breast and lung cancer, but not in testicular germ cell tumours (English)

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object named as

J Lukas

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object named as

J Bartek

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Niels E. Skakkebæk

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object named as

N E Skakkebaek

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Jahn M. Nesland

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object named as

J M Nesland

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Ewa Rajpert-De Meyts

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object named as

E Rajpert-De Meyts

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Zuzana Hořejší

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author name string

J Bartkova

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Z Horejsí

2

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M Sehested

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M Stucki

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S Jackson

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language of work or name

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publication date

22 November 2007

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26

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53

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7414-22

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ATM activation in normal human tissues and testicular cancer

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1210553

21 January 2018

Telomerase activity in germ cell cancers and mature teratomas.

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1210553

7 January 2021

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Initiating cellular stress responses

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1210553

7 January 2021

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Chk1 and Chk2 kinases in checkpoint control and cancer

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1210553

7 January 2021

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DNA damage checkpoints: from initiation to recovery or adaptation

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1210553

7 January 2021

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Checking on DNA damage in S phase

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1210553

7 January 2021

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TOPping up ATR activity.

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1210553

7 January 2021

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DNA damage response as a candidate anti-cancer barrier in early human tumorigenesis

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1210553

7 January 2021

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Deregulation of the G1/S-phase control in human testicular germ cell tumours

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1210553

7 January 2021

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Oncogene-induced senescence is part of the tumorigenesis barrier imposed by DNA damage checkpoints

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1210553

7 January 2021

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The cellular response to general and programmed DNA double strand breaks

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1210553

7 January 2021

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Dynamic assembly and sustained retention of 53BP1 at the sites of DNA damage are controlled by Mdc1/NFBD1

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1210553

7 January 2021

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A DNA damage checkpoint response in telomere-initiated senescence

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1210553

7 January 2021

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Oncogene-induced senescence is a DNA damage response triggered by DNA hyper-replication

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1210553

7 January 2021

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53BP1 functions in an ATM-dependent checkpoint pathway that is constitutively activated in human cancer

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1210553

7 January 2021

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MDC1 is required for the intra-S-phase DNA damage checkpoint

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1210553

7 January 2021

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Activation of the DNA damage checkpoint and genomic instability in human precancerous lesions

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1210553

7 January 2021

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Distinct functional domains of Nbs1 modulate the timing and magnitude of ATM activation after low doses of ionizing radiation

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1210553

7 January 2021

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Methylated lysine 79 of histone H3 targets 53BP1 to DNA double-strand breaks

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1210553

7 January 2021

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ATM- and cell cycle-dependent regulation of ATR in response to DNA double-strand breaks

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1210553

7 January 2021

based on heuristic

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Cell-cycle checkpoints and cancer

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1210553

7 January 2021

based on heuristic

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Claspin, a novel protein required for the activation of Chk1 during a DNA replication checkpoint response in Xenopus egg extracts

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1210553

7 January 2021

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TopBP1 activates the ATR-ATRIP complex

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210553

7 January 2021

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Differentiation-induced radioresistance in muscle cells

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1210553

7 January 2021

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Claspin operates downstream of TopBP1 to direct ATR signaling towards Chk1 activation

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210553

7 January 2021

based on heuristic

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MDC1 maintains genomic stability by participating in the amplification of ATM-dependent DNA damage signals

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210553

7 January 2021

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Mdc1 couples DNA double-strand break recognition by Nbs1 with its H2AX-dependent chromatin retention

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210553

7 January 2021

based on heuristic

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Mammalian cell cycle checkpoints: signalling pathways and their organization in space and time

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210553

7 January 2021

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A functionally inactive p53 protein in teratocarcinoma cells is activated by either DNA damage or cellular differentiation

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210553

7 January 2021

based on heuristic

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53BP1, an activator of ATM in response to DNA damage

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210553

7 January 2021

based on heuristic

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53BP1 and p53 synergize to suppress genomic instability and lymphomagenesis.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210553

7 January 2021

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The CHEK2 gene and inherited breast cancer susceptibility

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210553

7 January 2021

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Germ cell-like telomeric length homeostasis in nonseminomatous testicular germ cell tumors

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210553

7 January 2021

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Testicular germ-cell tumours in a broader perspective.

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1210553

7 January 2021

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The cellular response to DNA double-strand breaks: defining the sensors and mediators

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210553

7 January 2021

based on heuristic

inferred from DOI database lookup

ATM promotes apoptosis and suppresses tumorigenesis in response to Myc.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210553

7 January 2021

based on heuristic

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Developmental model for the pathogenesis of testicular carcinoma in situ: genetic and environmental aspects

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210553

7 January 2021

based on heuristic

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p53 binding protein 1 (53BP1) is an early participant in the cellular response to DNA double-strand breaks

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210553

7 January 2021

based on heuristic

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ATM and related protein kinases: safeguarding genome integrity

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1210553

7 January 2021

based on heuristic

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MDC1 is a mediator of the mammalian DNA damage checkpoint

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210553

7 January 2021

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MDC1 directly binds phosphorylated histone H2AX to regulate cellular responses to DNA double-strand breaks

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210553

7 January 2021

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gammaH2AX and MDC1: anchoring the DNA-damage-response machinery to broken chromosomes

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210553

7 January 2021

based on heuristic

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DNA damage foci at dysfunctional telomeres

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210553

7 January 2021

based on heuristic

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Retinoblastoma pathway defects show differential ability to activate the constitutive DNA damage response in human tumorigenesis

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210553

7 January 2021

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53BP1 cooperates with p53 and functions as a haploinsufficient tumor suppressor in mice

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210553

7 January 2021

based on heuristic

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p53 Binding protein 53BP1 is required for DNA damage responses and tumor suppression in mice

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210553

7 January 2021

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NFBD1/MDC1 regulates ionizing radiation-induced focus formation by DNA checkpoint signaling and repair factors

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210553

7 January 2021

based on heuristic

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