(Q28307990)

English

Fluoxetine- and norfluoxetine-mediated complex drug-drug interactions: in vitro to in vivo correlation of effects on CYP2D6, CYP2C19, and CYP3A4

scientific article

In more languages

Statements

scholarly article

0 references

Fluoxetine- and norfluoxetine-mediated complex drug-drug interactions: in vitro to in vivo correlation of effects on CYP2D6, CYP2C19, and CYP3A4 (English)

0 references

drug interaction

0 references

author name string

J E Sager

1

0 references

J D Lutz

2

0 references

R S Foti

3

0 references

C Davis

4

0 references

K L Kunze

5

0 references

N Isoherranen

6

0 references

language of work or name

0 references

publication date

June 2014

0 references

Clinical Pharmacology & Therapeutics

0 references

95

0 references

6

0 references

653-62

0 references

Inhibition of CYP2C19 and CYP3A4 by omeprazole metabolites and their contribution to drug-drug interactions

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4029899

20 March 2017

Importance of multi-p450 inhibition in drug-drug interactions: evaluation of incidence, inhibition magnitude, and prediction from in vitro data

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4029899

20 March 2017

Influence of CYP3A5 genotype on the pharmacokinetics and pharmacodynamics of the cytochrome P4503A probes alfentanil and midazolam

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4029899

20 March 2017

Clinical pharmacokinetics of fluoxetine

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4029899

20 March 2017

A PBPK Model to Predict Disposition of CYP3A-Metabolized Drugs in Pregnant Women: Verification and Discerning the Site of CYP3A Induction

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4029899

29 September 2017

Stereoselective inhibition of CYP2C19 and CYP3A4 by fluoxetine and its metabolite: implications for risk assessment of multiple time-dependent inhibitor systems

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4029899

29 September 2017

A physiologically based pharmacokinetic model to predict disposition of CYP2D6 and CYP1A2 metabolized drugs in pregnant women

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4029899

29 September 2017

Risk assessment of mechanism-based inactivation in drug-drug interactions

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4029899

29 September 2017

Evaluation of 6β-hydroxycortisol, 6β-hydroxycortisone, and a combination of the two as endogenous probes for inhibition of CYP3A4 in vivo

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4029899

29 September 2017

Accurate prediction of dose-dependent CYP3A4 inhibition by itraconazole and its metabolites from in vitro inhibition data

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4029899

29 September 2017

Selection of alternative CYP3A4 probe substrates for clinical drug interaction studies using in vitro data and in vivo simulation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4029899

29 September 2017

Metabolism and disposition of the thienopyridine antiplatelet drugs ticlopidine, clopidogrel, and prasugrel in humans

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4029899

29 September 2017

Comparison of different algorithms for predicting clinical drug-drug interactions, based on the use of CYP3A4 in vitro data: predictions of compounds as precipitants of interaction

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4029899

29 September 2017

Influence of omeprazole on the antiplatelet action of clopidogrel associated with aspirin: the randomized, double-blind OCLA (Omeprazole CLopidogrel Aspirin) study

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4029899

29 September 2017

Stochastic prediction of CYP3A-mediated inhibition of midazolam clearance by ketoconazole

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4029899

29 September 2017

A critical evaluation of the experimental design of studies of mechanism based enzyme inhibition, with implications for in vitro-in vivo extrapolation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4029899

29 September 2017

The influence of CYP2D6 polymorphism and quinidine on the disposition and antitussive effect of dextromethorphan in humans.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4029899

29 September 2017

Omeprazole: pharmacokinetics and metabolism in man.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4029899

29 September 2017

Physiologically based mechanistic modelling to predict complex drug-drug interactions involving simultaneous competitive and time-dependent enzyme inhibition by parent compound and its metabolite in both liver and gut - the effect of diltiazem on th

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4029899

2 June 2018

P-glycoprotein-mediated transport of digitoxin, alpha-methyldigoxin and beta-acetyldigoxin

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4029899

2 June 2018

Omission of the deconjugation step in urine analysis and the unaltered outcome of CYP2D6 phenotyping with dextromethorphan

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4029899

2 June 2018

Quantification and mechanism of the fluoxetine and tricyclic antidepressant interaction

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4029899

2 June 2018

Plasma concentrations of the enantiomers of fluoxetine and norfluoxetine: sources of variability and preliminary observations on relations with clinical response

1 reference

https://api.crossref.org/works/10.1038%2FCLPT.2014.50

21 January 2018

Influence of CYP2C9, 2C19 and 2D6 genetic polymorphisms on the steady-state plasma concentrations of the enantiomers of fluoxetine and norfluoxetine

1 reference

https://api.crossref.org/works/10.1038%2FCLPT.2014.50

21 January 2018

Effect of fluoxetine on the pharmacokinetics of lansoprazole: a two-treatment period study in healthy male subjects.

1 reference

https://api.crossref.org/works/10.1038%2FCLPT.2014.50

21 January 2018

Pharmacokinetic and Pharmacodynamic Interactions of Oral Midazolam with Ketoconazole, Fluoxetine, Fluvoxamine, and Nefazodone

1 reference

https://api.crossref.org/works/10.1038%2FCLPT.2014.50

21 January 2018

Effect of potent CYP2D6 inhibition by paroxetine on atomoxetine pharmacokinetics

1 reference

https://api.crossref.org/works/10.1038%2FCLPT.2014.50

21 January 2018

Identification of the human cytochromes P450 responsible for atomoxetine metabolism

1 reference

https://api.crossref.org/works/10.1038%2FCLPT.2014.50

21 January 2018

Comparison of the interaction potential of a new proton pump inhibitor, E3810, versus omeprazole with diazepam in extensive and poor metabolizers of S-mephenytoin 4′-hydroxylation*

1 reference

https://api.crossref.org/works/10.1038%2FCLPT.2014.50

21 January 2018

Development of the "Inje cocktail" for high-throughput evaluation of five human cytochrome P450 isoforms in vivo

1 reference

https://api.crossref.org/works/10.1038%2FCLPT.2014.50

21 January 2018

Dextromethorphan to dextrorphan urinary metabolic ratio does not reflect dextromethorphan oral clearance

1 reference

https://api.crossref.org/works/10.1038%2FCLPT.2014.50

21 January 2018

Concentrations of the enantiomers of fluoxetine and norfluoxetine after multiple doses of fluoxetine in cytochrome P4502D6 poor and extensive metabolizers.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4029899

27 November 2018

Identification of the human cytochromes p450 responsible for in vitro formation of R- and S-norfluoxetine.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4029899

27 November 2018

Diazepam metabolism by cDNA-expressed human 2C P450s: identification of P4502C18 and P4502C19 as low K(M) diazepam N-demethylases.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4029899

27 November 2018

The pharmacokinetics of omeprazole in humans--a study of single intravenous and oral doses

1 reference

https://pubmed.ncbi.nlm.nih.gov/24569517

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The stereoselective metabolism of fluoxetine in poor and extensive metabolizers of sparteine

1 reference

https://pubmed.ncbi.nlm.nih.gov/24569517

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mechanism-based inactivation of human cytochrome p450 enzymes and the prediction of drug-drug interactions

1 reference

https://pubmed.ncbi.nlm.nih.gov/24569517

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Increased carbamazepine plasma concentrations after fluoxetine coadministration

1 reference

https://pubmed.ncbi.nlm.nih.gov/24569517

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effects of clarithromycin on the metabolism of omeprazole in relation to CYP2C19 genotype status in humans

1 reference

https://pubmed.ncbi.nlm.nih.gov/24569517

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Absolute bioavailability and metabolism of omeprazole in relation to CYP2C19 genotypes following single intravenous and oral administrations

1 reference

https://pubmed.ncbi.nlm.nih.gov/24569517

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Interaction of the enantiomers of fluoxetine and norfluoxetine with human liver cytochromes P450

1 reference

https://pubmed.ncbi.nlm.nih.gov/24569517

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Fluoxetine impairs clearance of alprazolam but not of clonazepam

1 reference

https://pubmed.ncbi.nlm.nih.gov/24569517

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1038/CLPT.2014.50

0 references

PMC publication ID

0 references

PubMed publication ID

0 references

ResearchGate publication ID

0 references

Sitelinks

Wikipedia(0 entries)

Wikibooks(0 entries)

Wikinews(0 entries)

Wikiquote(0 entries)

Wikisource(0 entries)

Wikiversity(0 entries)

Wikivoyage(0 entries)

Wiktionary(0 entries)

Multilingual sites(0 entries)

Retrieved from "https://www.wikidata.org/w/index.php?title=Q28307990&oldid=1646443421"