(Q28473113)

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Structure-activity relationship and substrate-dependent phenomena in effects of ginsenosides on activities of drug-metabolizing P450 enzymes

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scholarly article

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Structure-activity relationship and substrate-dependent phenomena in effects of ginsenosides on activities of drug-metabolizing P450 enzymes (English)

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7

object named as

Ruiwen Zhang

author given names

Ruiwen

author last names

Zhang

1 reference

PubMed publication ID

20 October 2023

8

object named as

Hui Wang

author given names

Hui

author last names

Wang

1 reference

PubMed publication ID

20 October 2023

author name string

Miao Hao

1

author given names

Miao

author last names

Hao

1 reference

PubMed publication ID

20 October 2023

Yuqing Zhao

2

author given names

Yuqing

author last names

Zhao

1 reference

PubMed publication ID

20 October 2023

Peizhan Chen

3

author given names

Peizhan

author last names

Chen

1 reference

PubMed publication ID

20 October 2023

He Huang

4

author given names

He

author last names

Huang

1 reference

PubMed publication ID

20 October 2023

Hong Liu

5

author given names

Hong

author last names

Liu

1 reference

PubMed publication ID

20 October 2023

Hualiang Jiang

6

author given names

Hualiang

author last names

Jiang

1 reference

PubMed publication ID

20 October 2023

language of work or name

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publication date

16 July 2008

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3

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7

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e2697

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copyright license

Creative Commons Attribution 4.0 International

16 July 2008

1 reference

April 2022 Public Data File from Crossref

copyright status

0 references

Analysis methods of ginsenosides

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2442655

19 March 2017

Ginseng pharmacology: multiple constituents and multiple actions

2 references

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2442655

19 March 2017

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2442655

29 September 2017

Energetics of heterotropic cooperativity between alpha-naphthoflavone and testosterone binding to CYP3A4

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2442655

29 September 2017

Isolation, structural determination, and evaluation of the biological activity of 20(S)-25-methoxyl-dammarane-3beta, 12beta, 20-triol [20(S)-25-OCH3-PPD], a novel natural product from Panax notoginseng

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2442655

29 September 2017

Prediction of in vivo drug-drug interactions from in vitro data : factors affecting prototypic drug-drug interactions involving CYP2C9, CYP2D6 and CYP3A4.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2442655

29 September 2017

In vitro anti-cancer activity and structure-activity relationships of natural products isolated from fruits of Panax ginseng

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2442655

29 September 2017

Carbamazepine and valproate for the treatment of bipolar disorder: a review of the literature

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2442655

29 September 2017

Predicting in vivo drug interactions from in vitro drug discovery data

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2442655

29 September 2017

A simultaneous assessment of CYP3A4 metabolism and induction in the DPX-2 cell line

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2442655

29 September 2017

Heteroactivation of cytochrome P450 1A1 by teas and tea polyphenols.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2442655

29 September 2017

Herb-drug interactions: an overview of the clinical evidence

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2442655

29 September 2017

Cancer prevention and therapeutics: Panax ginseng.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2442655

29 September 2017

Proof of the mysterious efficacy of ginseng: basic and clinical trials: metabolic activation of ginsenoside: deglycosylation by intestinal bacteria and esterification with fatty acid

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2442655

29 September 2017

Herbal remedies in the United States: potential adverse interactions with anticancer agents

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2442655

29 September 2017

The inhibitory effects of herbal components on CYP2C9 and CYP3A4 catalytic activities in human liver microsomes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2442655

29 September 2017

A high throughput screening assay to screen for CYP2E1 metabolism and inhibition using a fluorogenic vivid p450 substrate

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2442655

29 September 2017

Effect of St John's wort and ginseng on the pharmacokinetics and pharmacodynamics of warfarin in healthy subjects

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2442655

29 September 2017

High-throughput screening for stability and inhibitory activity of compounds toward cytochrome P450-mediated metabolism

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2442655

29 September 2017

Herb-drug interactions

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2442655

29 September 2017

In vitro interaction of the HIV protease inhibitor ritonavir with herbal constituents: changes in P-gp and CYP3A4 activity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2442655

2 June 2018

High-throughput screening assays for CYP2B6 metabolism and inhibition using fluorogenic vivid substrates

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2442655

2 June 2018

Effects of ginseng components on c-DNA-expressed cytochrome P450 enzyme catalytic activity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2442655

2 June 2018

In vitro effect of standardized ginseng extracts and individual ginsenosides on the catalytic activity of human CYP1A1, CYP1A2, and CYP1B1.

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0002697

21 January 2018

Cytochrome P450 inhibition using recombinant proteins and mass spectrometry/multiple reaction monitoring technology in a cassette incubation

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0002697

21 January 2018

Effect of antifungal drugs on cytochrome P450 (CYP) 2C9, CYP2C19, and CYP3A4 activities in human liver microsomes

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0002697

21 January 2018

High-throughput screening of inhibitory potential of nine cytochrome P450 enzymes in vitro using liquid chromatography/tandem mass spectrometry

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0002697

21 January 2018

High-throughput screening assays for the assessment of CYP2C9*1, CYP2C9*2, and CYP2C9*3 metabolism using fluorogenic Vivid substrates.

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0002697

21 January 2018

Simultaneous determination of ginsenoside Rb(1) and Rg(1) in human plasma by liquid chromatography-mass spectrometry

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0002697

21 January 2018

Substrate dependent inhibition profiles of fourteen drugs on CYP3A4 activity measured by a high throughput LCMS/MS method with four probe drugs, midazolam, testosterone, nifedipine and terfenadine

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0002697

21 January 2018

Effects of endogenous steroids on CYP3A4-mediated drug metabolism by human liver microsomes

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0002697

21 January 2018

CYP3A4 and CYP3A7-mediated carbamazepine 10,11-epoxidation are activated by differential endogenous steroids

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0002697

21 January 2018

The structure of human microsomal cytochrome P450 3A4 determined by X-ray crystallography to 2.05-A resolution

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0002697

21 January 2018

Cooperative binding of midazolam with testosterone and alpha-naphthoflavone within the CYP3A4 active site: a NMR T1 paramagnetic relaxation study

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0002697

21 January 2018

Direct interaction between substrates and endogenous steroids in the active site may change the activity of cytochrome P450 3A4.

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0002697

21 January 2018

Cytochrome P450 phenotypic ratios for predicting herb-drug interactions in humans

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0002697

21 January 2018

Testosterone, 7-benzyloxyquinoline, and 7-benzyloxy-4-trifluoromethyl-coumarin bind to different domains within the active site of cytochrome P450 3A4.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2442655

27 November 2018

Substrate-dependent modulation of CYP3A4 catalytic activity: analysis of 27 test compounds with four fluorometric substrates.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2442655

27 November 2018

Human cytochrome P-450 3A4: in vitro drug-drug interaction patterns are substrate-dependent.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2442655

27 November 2018

Determination of ginsenoside Rg3 in plasma by solid-phase extraction and high-performance liquid chromatography for pharmacokinetic study

1 reference

https://pubmed.ncbi.nlm.nih.gov/18628990

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

In vitro drug interactions of cytochrome p450: an evaluation of fluorogenic to conventional substrates

1 reference

https://pubmed.ncbi.nlm.nih.gov/18628990

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effects of individual ginsenosides, ginkgolides and flavonoids on CYP2C19 and CYP2D6 activity in human liver microsomes

1 reference

https://pubmed.ncbi.nlm.nih.gov/18628990

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Highly miniaturized formats for in vitro drug metabolism assays using vivid fluorescent substrates and recombinant human cytochrome P450 enzymes

1 reference

https://pubmed.ncbi.nlm.nih.gov/18628990

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Elucidation of distinct ligand binding sites for cytochrome P450 3A4

1 reference

https://pubmed.ncbi.nlm.nih.gov/18628990

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Designing better drugs: predicting cytochrome P450 metabolism

1 reference

https://pubmed.ncbi.nlm.nih.gov/18628990

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Alternative medicine use by patients with epilepsy

1 reference

https://pubmed.ncbi.nlm.nih.gov/18628990

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Ginsenoside metabolites, rather than naturally occurring ginsenosides, lead to inhibition of human cytochrome P450 enzymes

1 reference

https://pubmed.ncbi.nlm.nih.gov/18628990

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1371/JOURNAL.PONE.0002697

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2008PLoSO...3.2697H

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PubMed publication ID

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