(Q44982176)

7 December 2017

The structure of human microsomal cytochrome P450 3A4 determined by X-ray crystallography to 2.05-A resolution (English)

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7 December 2017

X-ray crystallography

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author name string

Jason K Yano

1

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7 December 2017

Michael R Wester

2

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7 December 2017

Guillaume A Schoch

3

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7 December 2017

Keith J Griffin

4

1 reference

7 December 2017

C David Stout

5

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7 December 2017

Eric F Johnson

6

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7 December 2017

language of work or name

English

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publication date

16 July 2004

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Journal of Biological Chemistry

7 December 2017

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7 December 2017

279

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7 December 2017

38091-38094

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7 December 2017

37

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Substrates of human hepatic cytochrome P450 3A4.

7 December 2017

1 reference

https://api.crossref.org/works/10.1074%2FJBC.C400293200

Human cytochrome P450 enzymes: a status report summarizing their reactions, substrates, inducers, and inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.C400293200

Clinically important pharmacokinetic drug-drug interactions: role of cytochrome P450 enzymes

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.C400293200

Cytochrome P4503A (CYP3A) metabolism: prediction of in vivo activity in humans

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.C400293200

Engineering microsomal cytochrome P450 2C5 to be a soluble, monomeric enzyme. Mutations that alter aggregation, phospholipid dependence of catalysis, and membrane binding

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.C400293200

Mammalian microsomal cytochrome P450 monooxygenase: structural adaptations for membrane binding and functional diversity

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.C400293200

Structure of human microsomal cytochrome P450 2C8. Evidence for a peripheral fatty acid binding site

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.C400293200

Crystal structure of human cytochrome P450 2C9 with bound warfarin

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.C400293200

Structure of mammalian cytochrome P450 2C5 complexed with diclofenac at 2.1 A resolution: evidence for an induced fit model of substrate binding

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.C400293200

Structure of a substrate complex of mammalian cytochrome P450 2C5 at 2.3 A resolution: evidence for multiple substrate binding modes

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.C400293200

An open conformation of mammalian cytochrome P450 2B4 at 1.6-Å resolution

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.C400293200

Structure of mammalian cytochrome P450 2B4 complexed with 4-(4-chlorophenyl)imidazole at 1.9-A resolution: insight into the range of P450 conformations and the coordination of redox partner binding

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.C400293200

The structure of human cytochrome P450 2C9 complexed with flurbiprofen at 2.0-A resolution

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.C400293200

Analysis of human cytochrome P450 3A4 cooperativity: construction and characterization of a site-directed mutant that displays hyperbolic steroid hydroxylation kinetics

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.C400293200

Activation of CYP3A4: evidence for the simultaneous binding of two substrates in a cytochrome P450 active site.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.C400293200

Purification and crystallization of N-terminally truncated forms of microsomal cytochrome P450 2C5.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.C400293200

27 Measurement of substrate and inhibitor binding to microsomal cytochrome P-450 by optical-difference spectroscopy

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.C400293200

Identification of amino acid substitutions that confer a high affinity for sulfaphenazole binding and a high catalytic efficiency for warfarin metabolism to P450 2C19.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.C400293200

Crystallography & NMR System: A New Software Suite for Macromolecular Structure Determination

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.C400293200

Phenylalanine and tryptophan scanning mutagenesis of CYP3A4 substrate recognition site residues and effect on substrate oxidation and cooperativity

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.C400293200

Analysis of homotropic and heterotropic cooperativity of diazepam oxidation by CYP3A4 using site-directed mutagenesis and kinetic modeling

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.C400293200

The importance of SRS-1 residues in catalytic specificity of human cytochrome P450 3A4.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.C400293200

Amino acid 305 determines catalytic center accessibility in CYP3A4.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.C400293200

CYP3A4 active site volume modification by mutagenesis of leucine 211.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.C400293200

The catalytic pathway of cytochrome p450cam at atomic resolution

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.C400293200

Kinetic isotope effects implicate two electrophilic oxidants in cytochrome p450-catalyzed hydroxylations

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.C400293200

Cytochrome P450 3A4-mediated oxidative conversion of a cyano to an amide group in the metabolism of pinacidil

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.C400293200

Crystallization and preliminary X-ray diffraction analysis of fatty-acid hydroxylase cytochrome P450BSbeta from Bacillus subtilis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.C400293200

Interactions of peroxyquinols with cytochromes P450 2B1, 3A1, and 3A5: influence of the apoprotein on heterolytic versus homolytic O-O bond cleavage

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.C400293200

Detection, delineation, measurement and display of cavities in macromolecular structures

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.C400293200

21 January 2018

Identifiers

DOI

10.1074/JBC.C400293200

1 reference

7 December 2017

1 reference