(Q41456111)

30 September 2017

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title

Cytochrome P4503A (CYP3A) metabolism: prediction of in vivo activity in humans (English)

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30 September 2017

G R Wilkinson

1

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30 September 2017

publication date

1 October 1996

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Journal of Pharmacokinetics and Pharmacodynamics

30 September 2017

published in

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30 September 2017

volume

24

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30 September 2017

issue

5

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30 September 2017

page(s)

475-490

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https://scigraph.springernature.com/pub.10.1007/bf02353475

30 September 2017

exact match

0 references

cites work

The human drug metabolizing cytochromes P450.

1 reference

https://api.crossref.org/works/10.1007%2FBF02353475

Expression of cytochrome P450 3A in amphibian, rat, and human kidney

21 January 2018

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Differentiation of absorption and first-pass gut and hepatic metabolism in humans: Studies with cyclosporine*

21 January 2018

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Oral first-pass elimination of midazolam involves both gastrointestinal and hepatic CYP3A-mediated metabolism.

21 January 2018

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Letter: Anti-epileptic drugs and failure of oral contraceptives.

21 January 2018

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Grapefruit juice and drugs. How significant is the interaction?

21 January 2018

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Interaction between grapefruit juice and midazolam in humans*

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FBF02353475

Gender effects in pharmacokinetics and pharmacodynamics

21 January 2018

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https://api.crossref.org/works/10.1007%2FBF02353475

Clinical pharmacokinetics of ketoconazole

21 January 2018

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https://api.crossref.org/works/10.1007%2FBF02353475

The use of therapeutic drug monitoring to optimise immunosuppressive therapy

21 January 2018

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https://api.crossref.org/works/10.1007%2FBF02353475

Cyclosporine metabolism in human liver: identification of a cytochrome P-450III gene family as the major cyclosporine-metabolizing enzyme explains interactions of cyclosporine with other drugs.

21 January 2018

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https://api.crossref.org/works/10.1007%2FBF02353475

Pharmacokinetic drug interactions with cyclosporin (Part I).

21 January 2018

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Report on the international workshop on the use of human in vitro liver preparations to study drug metabolism in drug development. Held at Utrecht, The Netherlands, 6-8 September 1994.

21 January 2018

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Noninvasive tests of CYP3A enzymes

21 January 2018

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21 January 2018

12 December 2020

Mechanism of the cardiotoxic actions of terfenadine

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12 December 2020

Bioavailability of terfenadine in man

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12 December 2020

Pharmacokinetics and biotransformation studies of terfenadine in man

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12 December 2020

Metabolism of cyclosporin A. IV. Purification and identification of the rifampicin-inducible human liver cytochrome P-450 (cyclosporin A oxidase) as a product of P450IIIA gene subfamily

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12 December 2020

Cyclosporin A drug interactions. Screening for inducers and inhibitors of cytochrome P-450 (cyclosporin A oxidase) in primary cultures of human hepatocytes and in liver microsomes.

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12 December 2020

The simultaneous use of rifampicin and other antitubercular agents with oral contraceptives

1 reference

12 December 2020

Changes in the pharmacokinetics and electrocardiographic pharmacodynamics of terfenadine with concomitant administration of erythromycin

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12 December 2020

The effect of fluconazole on the steady-state pharmacokinetics and electrocardiographic pharmacodynamics of terfenadine in humans

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12 December 2020

In vitro techniques for studying drug metabolism

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12 December 2020

Pharmacokinetics of oral nifedipine in different populations

1 reference

12 December 2020

Itraconazole affects single-dose terfenadine pharmacokinetics and cardiac repolarization pharmacodynamics

1 reference

12 December 2020

Use of in vitro human metabolism studies in drug development. An industrial perspective

1 reference

12 December 2020

Disposition of intravenous and oral cyclosporine after administration with grapefruit juice

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12 December 2020

Itraconazole prevents terfenadine metabolism and increases risk of torsades de pointes ventricular tachycardia

1 reference

12 December 2020

Understanding consequences of concurrent therapies

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12 December 2020

Torsades de pointes occurring in association with terfenadine use

1 reference

12 December 2020

Terfenadine-ketoconazole interaction. Pharmacokinetic and electrocardiographic consequences

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12 December 2020

Ethnic differences in nifedipine kinetics: comparisons between Nigerians, Caucasians and South Asians.

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12 December 2020

Identifiers

DOI

10.1007/BF02353475

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30 September 2017

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