(Q28476642)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21209952%20AND%20SRC:MED&resulttype=core&format=json

19 January 2020

title

Oral methylthioadenosine administration attenuates fibrosis and chronic liver disease progression in Mdr2-/- mice (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21209952%20AND%20SRC:MED&resulttype=core&format=json

19 January 2020

1 reference

1

1 reference

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Carlos M Rodriguez-Ortigosa

19 January 2020

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21209952%20AND%20SRC:MED&resulttype=core&format=json

19 January 2020

Jesus M Banales

5

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21209952%20AND%20SRC:MED&resulttype=core&format=json

19 January 2020

Saioa Goñi

7

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21209952%20AND%20SRC:MED&resulttype=core&format=json

19 January 2020

Juan Angel Recio

11

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21209952%20AND%20SRC:MED&resulttype=core&format=json

19 January 2020

Sophie Lotersztajn

12

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21209952%20AND%20SRC:MED&resulttype=core&format=json

19 January 2020

Jesús Prieto

13

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21209952%20AND%20SRC:MED&resulttype=core&format=json

19 January 2020

Carmen Berasain

14

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21209952%20AND%20SRC:MED&resulttype=core&format=json

19 January 2020

Matias Avila

17

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21209952%20AND%20SRC:MED&resulttype=core&format=json

19 January 2020

author name string

Carmen Gil-Puig

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21209952%20AND%20SRC:MED&resulttype=core&format=json

19 January 2020

Maite G Fernández-Barrena

3

1 reference

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19 January 2020

Raquel Urtasun

6

1 reference

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19 January 2020

Miriam Méndez

8

1 reference

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19 January 2020

Sara Arcelus

9

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21209952%20AND%20SRC:MED&resulttype=core&format=json

19 January 2020

Nerea Juanarena

10

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21209952%20AND%20SRC:MED&resulttype=core&format=json

19 January 2020

Fernando J Corrales

15

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21209952%20AND%20SRC:MED&resulttype=core&format=json

19 January 2020

Jon Lecanda

16

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21209952%20AND%20SRC:MED&resulttype=core&format=json

19 January 2020

language of work or name

English

0 references

publication date

29 December 2010

1 reference

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19 January 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21209952%20AND%20SRC:MED&resulttype=core&format=json

19 January 2020

volume

5

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21209952%20AND%20SRC:MED&resulttype=core&format=json

19 January 2020

issue

12

1 reference

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19 January 2020

page(s)

e15690

1 reference

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Creative Commons Attribution 4.0 International

19 January 2020

copyright license

start time

29 December 2010

1 reference

April 2022 Public Data File from Crossref

copyright status

copyrighted

0 references

cites work

Metabolic syndrome and hepatocellular carcinoma: two growing epidemics with a potential link

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A PHD finger of NURF couples histone H3 lysine 4 trimethylation with chromatin remodelling

19 March 2017

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Adenosine receptors as therapeutic targets

19 March 2017

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Methylthioadenosine phosphorylase gene expression is impaired in human liver cirrhosis and hepatocarcinoma

19 March 2017

1 reference

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A chromatin landmark and transcription initiation at most promoters in human cells

19 March 2017

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7 April 2017

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NF-kappaB functions as a tumour promoter in inflammation-associated cancer

7 April 2017

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Mechanisms of hepatic fibrogenesis

7 April 2017

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Methylthioadenosine (MTA) inhibits melanoma cell proliferation and in vivo tumor growth

7 April 2017

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A2B adenosine receptors protect against sepsis-induced mortality by dampening excessive inflammation

29 September 2017

1 reference

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Curcumin improves sclerosing cholangitis in Mdr2-/- mice by inhibition of cholangiocyte inflammatory response and portal myofibroblast proliferation

29 September 2017

1 reference

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Portal fibroblasts: Underappreciated mediators of biliary fibrosis

29 September 2017

1 reference

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MeCP2 controls an epigenetic pathway that promotes myofibroblast transdifferentiation and fibrosis

29 September 2017

1 reference

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Rationale and targets for antifibrotic therapies.

29 September 2017

1 reference

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Targeting liver fibrosis: strategies for development and validation of antifibrotic therapies.

29 September 2017

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A(2B) adenosine receptors in immunity and inflammation.

29 September 2017

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Transcriptional regulation of hepatic stellate cells

29 September 2017

1 reference

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Inflammation and liver cancer: new molecular links .

29 September 2017

1 reference

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The epidermal growth factor receptor ligand amphiregulin participates in the development of mouse liver fibrosis.

29 September 2017

1 reference

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Inhibition of integrin alphavbeta6 on cholangiocytes blocks transforming growth factor-beta activation and retards biliary fibrosis progression

29 September 2017

1 reference

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S-adenosylmethionine inhibits lipopolysaccharide-induced gene expression via modulation of histone methylation

29 September 2017

1 reference

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Methionine metabolism and liver disease

29 September 2017

1 reference

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Nuclear factor-kappaB and the hepatic inflammation-fibrosis-cancer axis

29 September 2017

1 reference

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Global challenges in liver disease

29 September 2017

1 reference

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Adenosine augments IL-10 production by macrophages through an A2B receptor-mediated posttranscriptional mechanism

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3012093

Fibrosis in chronic liver diseases: diagnosis and management

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3012093

Hepatic fibrosis: molecular mechanisms and drug targets

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3012093

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3012093

5'-methylthioadenosine modulates the inflammatory response to endotoxin in mice and in rat hepatocytes.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3012093

cDNA microarray analysis reveals a nuclear factor-kappaB-independent regulation of macrophage function by adenosine.

29 September 2017

1 reference

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Cytokine-stimulated nitric oxide production inhibits adenylyl cyclase and cAMP-dependent secretion in cholangiocytes

29 September 2017

1 reference

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Use of the A(2A) adenosine receptor as a physiological immunosuppressor and to engineer inflammation in vivo

29 September 2017

1 reference

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Chemoprevention of hepatocarcinogenesis: S-adenosyl-L-methionine

29 September 2017

1 reference

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Molecular cloning and sequence analysis of the promoter region of mouse cyclin D1 gene: implication in phorbol ester-induced tumour promotion

29 September 2017

1 reference

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Increased expression of monocyte chemotactic protein-1 during active hepatic fibrogenesis: correlation with monocyte infiltration.

29 September 2017

1 reference

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Cultured human liver fat-storing cells produce monocyte chemotactic protein-1. Regulation by proinflammatory cytokines.

29 September 2017

1 reference

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Modulation of hepatic fibrosis by c-Jun-N-terminal kinase inhibition

29 September 2017

1 reference

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Dysregulation of glutathione synthesis during cholestasis in mice: molecular mechanisms and therapeutic implications

2 June 2018

1 reference

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Effect of A2B adenosine receptor gene ablation on adenosine-dependent regulation of proinflammatory cytokines

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3012093

S-adenosylmethionine blocks collagen I production by preventing transforming growth factor-beta induction of the COL1A2 promoter

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3012093

5'-Deoxy-5'-methylthioadenosine: a nucleoside which differentiates between adenosine receptor types

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3012093

Peritumoral activated hepatic stellate cells predict poor clinical outcome in hepatocellular carcinoma after curative resection

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3012093

Molecular mechanisms of liver carcinogenesis in the mdr2-knockout mice

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3012093

Role of methionine adenosyltransferase 2A and S-adenosylmethionine in mitogen-induced growth of human colon cancer cells

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3012093

JunD is a profibrogenic transcription factor regulated by Jun N-terminal kinase-independent phosphorylation

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3012093

Deficiency of tenascin-C attenuates liver fibrosis in immune-mediated chronic hepatitis in mice.

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3012093

c-Jun N-terminal kinase plays a major role in murine acetaminophen hepatotoxicity

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3012093

Methylthioadenosine reverses brain autoimmune disease

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3012093

Multiple adaptive mechanisms to chronic liver disease revealed at early stages of liver carcinogenesis in the Mdr2-knockout mice

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3012093

Differential regulation of the JNK/AP-1 pathway by S-adenosylmethionine and methylthioadenosine in primary rat hepatocytes versus HuH7 hepatoma cells.

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3012093

Adenosine inhibits tumor necrosis factor-alpha release from mouse peritoneal macrophages via A2A and A2B but not the A3 adenosine receptor

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3012093

JNK mediates hepatic ischemia reperfusion injury

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3012093

The role of p70S6K in hepatic stellate cell collagen gene expression and cell proliferation

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3012093

Regurgitation of bile acids from leaky bile ducts causes sclerosing cholangitis in Mdr2 (Abcb4) knockout mice

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3012093

FGF2-induced chromatin remodeling regulates CNTF-mediated gene expression and astrocyte differentiation

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3012093

Protection of rat hepatocytes from apoptosis by inhibition of c-Jun N-terminal kinase

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3012093

Heme oxygenase-1 is an antifibrogenic protein in human hepatic myofibroblasts

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3012093

S-adenosylmethionine and methylthioadenosine are antiapoptotic in cultured rat hepatocytes but proapoptotic in human hepatoma cells.

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3012093

5'-Methylthioadenosine administration prevents lipid peroxidation and fibrogenesis induced in rat liver by carbon-tetrachloride intoxication.

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3012093

Mdr2 (Abcb4)-/- mice spontaneously develop severe biliary fibrosis via massive dysregulation of pro- and antifibrogenic genes

27 November 2018

1 reference

12 December 2020

Secretion of MCP-1/CCL2 by bile duct epithelia induces myofibroblastic transdifferentiation of portal fibroblasts

1 reference

12 December 2020

Prevention of severe toxic liver injury and oxidative stress in MCP-1-deficient mice

1 reference

12 December 2020

Expression of large tenascin-C splice variants by hepatic stellate cells/myofibroblasts in chronic hepatitis C

1 reference

12 December 2020

Multiple inflammatory-, tissue remodelling- and fibrosis genes are differentially transcribed in the livers of Abcb4 (-/ - ) mice harbouring chronic cholangitis

1 reference

12 December 2020

Expression of cyclins D1, D2 and E correlates with proliferation of rat stellate cells in culture

1 reference

12 December 2020

Biological effects of C-type natriuretic peptide in human myofibroblastic hepatic stellate cells

1 reference

12 December 2020

10.1371/JOURNAL.PONE.0015690

Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21209952%20AND%20SRC:MED&resulttype=core&format=json

19 January 2020

0 references

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21209952%20AND%20SRC:MED&resulttype=core&format=json

19 January 2020

PubMed publication ID

21209952

1 reference