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Targeting liver fibrosis: strategies for development and validation of antifibrotic therapies.
scientific article published on October 2009
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scholarly article
1 reference
stated in
Europe PubMed Central
PubMed ID
19711424
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19711424%20AND%20SRC:MED&resulttype=core&format=json
retrieved
6 February 2020
review article
1 reference
stated in
Europe PubMed Central
title
Targeting liver fibrosis: strategies for development and validation of antifibrotic therapies
(English)
1 reference
stated in
Europe PubMed Central
PubMed ID
19711424
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19711424%20AND%20SRC:MED&resulttype=core&format=json
retrieved
6 February 2020
author
Yury V Popov
series ordinal
1
1 reference
stated in
Europe PubMed Central
PubMed ID
19711424
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19711424%20AND%20SRC:MED&resulttype=core&format=json
retrieved
6 February 2020
Detlef Schuppan
series ordinal
2
object named as
Detlef Schuppan
1 reference
stated in
Europe PubMed Central
PubMed ID
19711424
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19711424%20AND%20SRC:MED&resulttype=core&format=json
retrieved
6 February 2020
language of work or name
English
0 references
publication date
1 October 2009
1 reference
stated in
Europe PubMed Central
PubMed ID
19711424
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19711424%20AND%20SRC:MED&resulttype=core&format=json
retrieved
6 February 2020
published in
Hepatology
1 reference
stated in
Europe PubMed Central
PubMed ID
19711424
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19711424%20AND%20SRC:MED&resulttype=core&format=json
retrieved
6 February 2020
volume
50
1 reference
stated in
Europe PubMed Central
PubMed ID
19711424
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19711424%20AND%20SRC:MED&resulttype=core&format=json
retrieved
6 February 2020
issue
4
1 reference
stated in
Europe PubMed Central
PubMed ID
19711424
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19711424%20AND%20SRC:MED&resulttype=core&format=json
retrieved
6 February 2020
page(s)
1294-1306
1 reference
stated in
Europe PubMed Central
PubMed ID
19711424
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19711424%20AND%20SRC:MED&resulttype=core&format=json
retrieved
6 February 2020
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7 January 2021
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7 January 2021
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Bone marrow-derived cells express matrix metalloproteinases and contribute to regression of liver fibrosis in mice.
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Fibrosis correlates with a ductular reaction in hepatitis C: roles of impaired replication, progenitor cells and steatosis
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Oval cell numbers in human chronic liver diseases are directly related to disease severity.
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Proliferating bile duct epithelial cells are a major source of connective tissue growth factor in rat biliary fibrosis
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Pathophysiology of the intrahepatic biliary epithelium
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Inhibition of integrin alphavbeta6 on cholangiocytes blocks transforming growth factor-beta activation and retards biliary fibrosis progression
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Procollagen expression by nonparenchymal rat liver cells in experimental biliary fibrosis.
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The hedgehog pathway regulates remodelling responses to biliary obstruction in rats.
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7 January 2021
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A significant proportion of myofibroblasts are of bone marrow origin in human liver fibrosis
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Gene expression profiles during hepatic stellate cell activation in culture and in vivo
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7 January 2021
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Human hepatic stellate cell lines, LX-1 and LX-2: new tools for analysis of hepatic fibrosis.
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7 January 2021
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Integrin alphavbeta6 is a marker of the progression of biliary and portal liver fibrosis and a novel target for antifibrotic therapies
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7 January 2021
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Hedgehog-mediated mesenchymal–epithelial interactions modulate hepatic response to bile duct ligation
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Inducible nitric oxide synthase upregulates cyclooxygenase-2 in mouse cholangiocytes promoting cell growth
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Common and unique mechanisms regulate fibrosis in various fibroproliferative diseases
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Fibrogenic cell fate during fibrotic tissue remodelling observed in rat and human cultured liver slices
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Precision-cut liver slices as a new model to study toxicity-induced hepatic stellate cell activation in a physiologic milieu
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Microscale culture of human liver cells for drug development.
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7 January 2021
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Microscale control of cell contact and spacing via three-component surface patterning
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7 January 2021
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Mdr2 (Abcb4)-/- mice spontaneously develop severe biliary fibrosis via massive dysregulation of pro- and antifibrogenic genes
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A new xenobiotic-induced mouse model of sclerosing cholangitis and biliary fibrosis
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Genome-wide analysis of hepatic fibrosis in inbred mice identifies the susceptibility locus Hfib1 on chromosome 15.
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Development of nonalcoholic steatohepatitis in insulin-resistant liver-specific S503A carcinoembryonic antigen-related cell adhesion molecule 1 mutant mice
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Transgenic mice expressing nuclear sterol regulatory element-binding protein 1c in adipose tissue exhibit liver histology similar to nonalcoholic steatohepatitis
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Conditional tetracycline-regulated expression of TGF-β1 in liver of transgenic mice leads to reversible intermediary fibrosis
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7 January 2021
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Antifibrotic therapy in chronic liver disease
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7 January 2021
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In vivo inhibition of rat stellate cell activation by soluble transforming growth factor beta type II receptor: a potential new therapy for hepatic fibrosis
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7 January 2021
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Development of TGF-beta signalling inhibitors for cancer therapy
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Crossref
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7 January 2021
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Inhibition of hepatic fibrogenesis by matrix metalloproteinase-9 mutants in mice
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7 January 2021
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Role of alphavbeta6 integrin in acute biliary fibrosis
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7 January 2021
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Herbal products for liver diseases: a therapeutic challenge for the new millennium
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Complementary and alternative medicine in hepatology: review of the evidence of efficacy
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7 January 2021
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Herbal hepatotoxicity
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7 January 2021
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inferred from DOI database lookup
Silibinin is a potent antiviral agent in patients with chronic hepatitis C not responding to pegylated interferon/ribavirin therapy.
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Drug repositioning: identifying and developing new uses for existing drugs
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Low-dose oral rapamycin treatment reduces fibrogenesis, improves liver function, and prolongs survival in rats with established liver cirrhosis
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Antidiabetic thiazolidinediones inhibit collagen synthesis and hepatic stellate cell activation in vivo and in vitro.
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Halofuginone induces matrix metalloproteinases in rat hepatic stellate cells via activation of p38 and NFkappaB.
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Halofuginone to prevent and treat thioacetamide-induced liver fibrosis in rats
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7 January 2021
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Antiangiogenic treatment with sunitinib ameliorates inflammatory infiltrate, fibrosis, and portal pressure in cirrhotic rats.
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7 January 2021
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Imatinib mesylate (STI-571) attenuates liver fibrosis development in rats.
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7 January 2021
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The preferential homing of a platelet derived growth factor receptor-recognizing macromolecule to fibroblast-like cells in fibrotic tissue
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Studies on the targeted delivery of the antifibrogenic compound mycophenolic acid to the hepatic stellate cell.
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7 January 2021
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Cellular targeting of the apoptosis-inducing compound gliotoxin to fibrotic rat livers.
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7 January 2021
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Antibody-targeted myofibroblast apoptosis reduces fibrosis during sustained liver injury.
1 reference
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7 January 2021
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Resolution of liver cirrhosis using vitamin A-coupled liposomes to deliver siRNA against a collagen-specific chaperone
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7 January 2021
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PDGF-receptor beta-targeted adenovirus redirects gene transfer from hepatocytes to activated stellate cells
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7 January 2021
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Liver biopsy
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7 January 2021
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Sampling error and intraobserver variation in liver biopsy in patients with chronic HCV infection
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7 January 2021
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7 January 2021
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Sampling variability of percutaneous liver biopsy in primary sclerosing cholangitis
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https://api.crossref.org/works/10.1002%2FHEP.23123
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7 January 2021
based on heuristic
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Sampling Variability of Liver Biopsy in Nonalcoholic Fatty Liver Disease
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7 January 2021
based on heuristic
inferred from DOI database lookup
Hepatic stellate cell activation in liver transplant patients with hepatitis C recurrence and in non-transplanted patients with chronic hepatitis C.
1 reference
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7 January 2021
based on heuristic
inferred from DOI database lookup
Histological-hemodynamic correlation in cirrhosis-a histological classification of the severity of cirrhosis
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7 January 2021
based on heuristic
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Hepatic venous pressure gradient predicts clinical decompensation in patients with compensated cirrhosis.
1 reference
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7 January 2021
based on heuristic
inferred from DOI database lookup
Technology Insight: noninvasive assessment of liver fibrosis by biochemical scores and elastography.
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https://api.crossref.org/works/10.1002%2FHEP.23123
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7 January 2021
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inferred from DOI database lookup
Diagnosis and quantitation of fibrosis
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7 January 2021
based on heuristic
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Noninvasive markers of fibrosis in nonalcoholic fatty liver disease: Validating the European Liver Fibrosis Panel and exploring simple markers
1 reference
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7 January 2021
based on heuristic
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Biochemical surrogate markers of liver fibrosis and activity in a randomized trial of peginterferon alfa-2b and ribavirin
1 reference
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https://api.crossref.org/works/10.1002%2FHEP.23123
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7 January 2021
based on heuristic
inferred from DOI database lookup
Estimation of stage-specific fibrosis progression rates in chronic hepatitis C virus infection: a meta-analysis and meta-regression
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7 January 2021
based on heuristic
inferred from DOI database lookup
Exceeding the limits of liver histology markers
1 reference
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reference URL
https://api.crossref.org/works/10.1002%2FHEP.23123
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7 January 2021
based on heuristic
inferred from DOI database lookup
Longitudinal assessment of histology surrogate markers (FibroTest-ActiTest) during lamivudine therapy in patients with chronic hepatitis B infection.
1 reference
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https://api.crossref.org/works/10.1002%2FHEP.23123
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7 January 2021
based on heuristic
inferred from DOI database lookup
An accurate definition of the status of inactive hepatitis B virus carrier by a combination of biomarkers (FibroTest-ActiTest) and viral load
1 reference
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https://api.crossref.org/works/10.1002%2FHEP.23123
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7 January 2021
based on heuristic
inferred from DOI database lookup
Diagnostic and prognostic values of noninvasive biomarkers of fibrosis in patients with alcoholic liver disease
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reference URL
https://api.crossref.org/works/10.1002%2FHEP.23123
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7 January 2021
based on heuristic
inferred from DOI database lookup
Prediction of clinical outcomes in primary biliary cirrhosis by serum enhanced liver fibrosis assay
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Crossref
reference URL
https://api.crossref.org/works/10.1002%2FHEP.23123
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7 January 2021
based on heuristic
inferred from DOI database lookup
Longitudinal evaluation of a fibrosis index combining MMP-1 and PIIINP compared with MMP-9, TIMP-1 and hyaluronic acid in patients with chronic hepatitis C treated by interferon-alpha and ribavirin.
1 reference
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https://api.crossref.org/works/10.1002%2FHEP.23123
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7 January 2021
based on heuristic
inferred from DOI database lookup
Progression of fibrosis in hepatitis C with and without schistosomiasis: Correlation with serum markers of fibrosis
1 reference
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reference URL
https://api.crossref.org/works/10.1002%2FHEP.23123
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7 January 2021
based on heuristic
inferred from DOI database lookup
Higher dimensional (Hi-D) separation strategies dramatically improve the potential for cancer biomarker detection in serum and plasma
1 reference
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reference URL
https://api.crossref.org/works/10.1002%2FHEP.23123
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7 January 2021
based on heuristic
inferred from DOI database lookup
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https://api.crossref.org/works/10.1002%2FHEP.23123
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7 January 2021
based on heuristic
inferred from DOI database lookup
Proteomics: the first decade and beyond
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https://api.crossref.org/works/10.1002%2FHEP.23123
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7 January 2021
based on heuristic
inferred from DOI database lookup
Serial changes in expression of functionally clustered genes in progression of liver fibrosis in hepatitis C patients
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FHEP.23123
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
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1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FHEP.23123
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
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1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FHEP.23123
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Computer-aided diagnosis of hepatic fibrosis: preliminary evaluation of MRI texture analysis using the finite difference method and an artificial neural network.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FHEP.23123
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Liver fibrosis: noninvasive diagnosis with double contrast material-enhanced MR imaging
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FHEP.23123
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Functional magnetic resonance imaging monitoring of pathological changes in rodent livers during hyperoxia and hypercapnia
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FHEP.23123
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Transient elastography: a new noninvasive method for assessment of hepatic fibrosis.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FHEP.23123
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Diagnosis of cirrhosis by transient elastography (FibroScan): a prospective study
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FHEP.23123
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Performance of transient elastography for the staging of liver fibrosis: a meta-analysis
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FHEP.23123
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Non-invasive evaluation of liver fibrosis using transient elastography
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FHEP.23123
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Transient elastography: a new surrogate marker of liver fibrosis influenced by major changes of transaminases
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FHEP.23123
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Reliability of transient elastography for the diagnosis of advanced fibrosis in chronic hepatitis C
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FHEP.23123
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Extrahepatic cholestasis increases liver stiffness (FibroScan) irrespective of fibrosis
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FHEP.23123
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
MR elastography of liver fibrosis: preliminary results comparing spin-echo and echo-planar imaging.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FHEP.23123
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Magnetic resonance elastography for the noninvasive staging of liver fibrosis.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FHEP.23123
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
New technologies for human cancer imaging
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FHEP.23123
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Selective depletion of macrophages reveals distinct, opposing roles during liver injury and repair
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FHEP.23123
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Attenuated liver fibrosis in the absence of B cells
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FHEP.23123
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Natural killer cells ameliorate liver fibrosis by killing activated stellate cells in NKG2D-dependent and tumor necrosis factor-related apoptosis-inducing ligand-dependent manners
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FHEP.23123
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Immune stimulation of hepatic fibrogenesis by CD8 cells and attenuation by transgenic interleukin-10 from hepatocytes
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FHEP.23123
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The bone marrow functionally contributes to liver fibrosis.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FHEP.23123
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Interstrain differences in susceptibility to non-alcoholic steatohepatitis.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FHEP.23123
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
An oral endothelin-A receptor antagonist blocks collagen synthesis and deposition in advanced rat liver fibrosis
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FHEP.23123
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
CB1 cannabinoid receptor antagonism: a new strategy for the treatment of liver fibrosis
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FHEP.23123
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
TLR4 enhances TGF-beta signaling and hepatic fibrosis
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FHEP.23123
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The Caspase Inhibitor IDN-6556 Attenuates Hepatic Injury and Fibrosis in the Bile Duct Ligated Mouse
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FHEP.23123
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The nuclear receptor SHP mediates inhibition of hepatic stellate cells by FXR and protects against liver fibrosis
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FHEP.23123
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Antifibrotic effect of silymarin in rat secondary biliary fibrosis is mediated by downregulation of procollagen alpha1(I) and TIMP-1
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FHEP.23123
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Effects of Sho-saiko-to, a Japanese herbal medicine, on hepatic fibrosis in rats
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FHEP.23123
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Prevention of liver cirrhosis in rats by curcumin
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FHEP.23123
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Herb medicine Inchin-ko-to (TJ-135) regulates PDGF-BB-dependent signaling pathways of hepatic stellate cells in primary culture and attenuates development of liver fibrosis induced by thioacetamide administration in rats
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FHEP.23123
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Salvia miltiorrhiza reduces experimentally-induced hepatic fibrosis in rats
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FHEP.23123
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Protection by and anti-oxidant mechanism of berberine against rat liver fibrosis induced by multiple hepatotoxic factors
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FHEP.23123
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Resveratrol prevents fibrosis, NF-kappaB activation and TGF-beta increases induced by chronic CCl4 treatment in rats
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1002%2FHEP.23123
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Identifiers
DOI
10.1002/HEP.23123
1 reference
stated in
Europe PubMed Central
PubMed ID
19711424
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19711424%20AND%20SRC:MED&resulttype=core&format=json
retrieved
6 February 2020
PubMed ID
19711424
1 reference
stated in
Europe PubMed Central
PubMed ID
19711424
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19711424%20AND%20SRC:MED&resulttype=core&format=json
retrieved
6 February 2020
ResearchGate publication ID
26771362
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