(Q28477995)

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Expression of mutant or cytosolic PrP in transgenic mice and cells is not associated with endoplasmic reticulum stress or proteasome dysfunction

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31 January 2020

Expression of mutant or cytosolic PrP in transgenic mice and cells is not associated with endoplasmic reticulum stress or proteasome dysfunction (English)

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31 January 2020

endoplasmic reticulum

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31 January 2020

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31 January 2020

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31 January 2020

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31 January 2020

Luigina Tagliavacca

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Luigina Tagliavacca

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31 January 2020

Daniele Imperiale

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Daniele Imperiale

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31 January 2020

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Elena Quaglio

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31 January 2020

Anna Garofoli

3

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31 January 2020

Sara Dossena

4

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31 January 2020

Ada De Luigi

5

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31 January 2020

Antonio Migheli

8

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31 January 2020

Gianluigi Forloni

11

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31 January 2020

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29 April 2011

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31 January 2020

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Europe PubMed Central

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31 January 2020

6

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31 January 2020

4

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31 January 2020

e19339

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21559407%20AND%20SRC:MED&resulttype=core&format=json

31 January 2020

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Creative Commons Attribution 4.0 International

29 April 2011

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April 2022 Public Data File from Crossref

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describes a project that uses

1 reference

Europe PubMed Central

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC3084828/fullTextXML

based on heuristic

inferred from PubMed Central ID database lookup

IRE1-mediated unconventional mRNA splicing and S2P-mediated ATF6 cleavage merge to regulate XBP1 in signaling the unfolded protein response

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3084828

19 March 2017

XBP1 mRNA is induced by ATF6 and spliced by IRE1 in response to ER stress to produce a highly active transcription factor

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3084828

19 March 2017

Proteasomes and ubiquitin are involved in the turnover of the wild-type prion protein

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3084828

19 March 2017

Prion diseases of humans and animals: their causes and molecular basis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3084828

19 March 2017

Mammalian transcription factor ATF6 is synthesized as a transmembrane protein and activated by proteolysis in response to endoplasmic reticulum stress

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3084828

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3084828

19 March 2017

Establishment of a noradrenergic clonal line of rat adrenal pheochromocytoma cells which respond to nerve growth factor

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3084828

19 March 2017

The orphan receptor serine/threonine kinase ALK7 signals arrest of proliferation and morphological differentiation in a neuronal cell line

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3084828

19 March 2017

Prion protein misfolding affects calcium homeostasis and sensitizes cells to endoplasmic reticulum stress

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3084828

29 September 2017

Transcriptional analysis implicates endoplasmic reticulum stress in bovine spongiform encephalopathy

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3084828

29 September 2017

Cell type-specific neuroprotective activity of untranslocated prion protein

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3084828

29 September 2017

A new fluorogenic peptide determines proteasome activity in single cells.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3084828

29 September 2017

Mutant prion protein expression is associated with an alteration of the Rab GDP dissociation inhibitor alpha (GDI)/Rab11 pathway

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3084828

29 September 2017

Prion neurotoxicity: insights from prion protein mutants

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3084828

29 September 2017

Fine-tuning of the unfolded protein response: Assembling the IRE1alpha interactome

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3084828

29 September 2017

Accumulation of ubiquitin conjugates in a polyglutamine disease model occurs without global ubiquitin/proteasome system impairment

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3084828

29 September 2017

Selective processing and metabolism of disease-causing mutant prion proteins

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3084828

29 September 2017

Identification of an intracellular site of prion conversion

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3084828

29 September 2017

Functional alterations of the ubiquitin-proteasome system in motor neurons of a mouse model of familial amyotrophic lateral sclerosis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3084828

29 September 2017

Reduced translocation of nascent prion protein during ER stress contributes to neurodegeneration

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3084828

29 September 2017

Endoplasmic reticulum stress, PrP trafficking, and neurodegeneration

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3084828

29 September 2017

Protein quality control in the early secretory pathway

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3084828

29 September 2017

Unfolded protein response transcription factor XBP-1 does not influence prion replication or pathogenesis.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3084828

29 September 2017

Disease-associated prion protein oligomers inhibit the 26S proteasome

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3084828

29 September 2017

The cellular prion protein (PrP(C)): its physiological function and role in disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3084828

29 September 2017

Perturbation of endoplasmic reticulum homeostasis facilitates prion replication.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3084828

29 September 2017

Substrate-specific translocational attenuation during ER stress defines a pre-emptive quality control pathway

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3084828

29 September 2017

The translocation inhibitor CAM741 interferes with vascular cell adhesion molecule 1 signal peptide insertion at the translocon

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3084828

29 September 2017

Conditions of endoplasmic reticulum stress favor the accumulation of cytosolic prion protein

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3084828

29 September 2017

Rapid and discriminatory diagnosis of scrapie and BSE in retro-pharyngeal lymph nodes of sheep

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3084828

29 September 2017

Progressively impaired proteasomal capacity during terminal plasma cell differentiation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3084828

29 September 2017

The unfolded protein response: a stress signaling pathway critical for health and disease.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3084828

29 September 2017

Prion disease genetics

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3084828

29 September 2017

The disulfide isomerase Grp58 is a protective factor against prion neurotoxicity.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3084828

29 September 2017

The highways and byways of prion protein trafficking

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3084828

29 September 2017

Bax deletion prevents neuronal loss but not neurological symptoms in a transgenic model of inherited prion disease.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3084828

29 September 2017

Caspase-12 and endoplasmic reticulum stress mediate neurotoxicity of pathological prion protein.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3084828

29 September 2017

The making of a professional secretory cell: architectural and functional changes in the ER during B lymphocyte plasma cell differentiation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3084828

29 September 2017

Molecular distinction between pathogenic and infectious properties of the prion protein

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3084828

29 September 2017

Overexpressed protein disulfide isomerase in brains of patients with sporadic Creutzfeldt-Jakob disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3084828

29 September 2017

Wild-type PrP and a mutant associated with prion disease are subject to retrograde transport and proteasome degradation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3084828

29 September 2017

Prion diseases: what is the neurotoxic molecule?

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3084828

29 September 2017

Sensitive detection of pathological prion protein by cyclic amplification of protein misfolding

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3084828

29 September 2017

Accumulation of protease-resistant prion protein (PrP) and apoptosis of cerebellar granule cells in transgenic mice expressing a PrP insertional mutation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3084828

29 September 2017

Prion protein NMR structure and familial human spongiform encephalopathies

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3084828

29 September 2017

Mutant and infectious prion proteins display common biochemical properties in cultured cells.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3084828

29 September 2017

Mouse polyclonal and monoclonal antibody to scrapie-associated fibril proteins

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3084828

29 September 2017

Prion pathogenesis is independent of caspase-12.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3084828

2 June 2018

Normal development and behaviour of mice lacking the neuronal cell-surface PrP protein

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3084828

2 June 2018

Evidence for synthesis of scrapie prion proteins in the endocytic pathway

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3084828

2 June 2018

Neurological illness in transgenic mice expressing a prion protein with an insertional mutation.

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0019339

21 January 2018

Mutant prion protein expression causes motor and memory deficits and abnormal sleep patterns in a transgenic mouse model.

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0019339

21 January 2018

Mutant PrP is delayed in its exit from the endoplasmic reticulum, but neither wild-type nor mutant PrP undergoes retrotranslocation prior to proteasomal degradation

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0019339

21 January 2018

Cytosolic prion protein (PrP) is not toxic in N2a cells and primary neurons expressing pathogenic PrP mutations

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0019339

21 January 2018

Overexpression of glucose-regulated protein 78 in colon cancer.

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0019339

21 January 2018

Pathogenesis of ER storage disorders: modulating Russell body biogenesis by altering proximal and distal quality control.

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0019339

21 January 2018

A transgenic mouse model of the ubiquitin/proteasome system

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0019339

21 January 2018

Neuronal dysfunction in a polyglutamine disease model occurs in the absence of ubiquitin-proteasome system impairment and inversely correlates with the degree of nuclear inclusion formation

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0019339

21 January 2018

Endoplasmic reticulum stress compromises the ubiquitin-proteasome system

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0019339

21 January 2018

Neurotoxicity and neurodegeneration when PrP accumulates in the cytosol

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0019339

21 January 2018

An endoplasmic-reticulum-specific apoptotic pathway is involved in prion and amyloid-beta peptides neurotoxicity.

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0019339

21 January 2018

Cell-free formation of protease-resistant prion protein.

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0019339

21 January 2018

The effect of disease-associated mutations on the folding pathway of human prion protein

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0019339

21 January 2018

Prion protein is ubiquitinated after developing protease resistance in the brains of scrapie-infected mice

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0019339

21 January 2018

Interplay between 20S proteasomes and prion proteins in scrapie disease

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0019339

21 January 2018

Increased expression of the transcription factors CCAAT-enhancer binding protein-beta (C/EBBeta) and C/EBzeta (CHOP) correlate with invasiveness of human colorectal cancer

1 reference

https://pubmed.ncbi.nlm.nih.gov/21559407

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Nerve growth factor-induced differentiation does not alter the biochemical properties of a mutant prion protein expressed in PC12 cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/21559407

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The scrapie-associated form of PrP is made from a cell surface precursor that is both protease- and phospholipase-sensitive

1 reference

https://pubmed.ncbi.nlm.nih.gov/21559407

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identification of intermediate steps in the conversion of a mutant prion protein to a scrapie-like form in cultured cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/21559407

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Endoplasmic reticulum stress features are prominent in Alzheimer disease but not in prion diseases in vivo

1 reference

https://pubmed.ncbi.nlm.nih.gov/21559407

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1371/JOURNAL.PONE.0019339

2 references

Consolidated OpenCitations Corpus – April 2017

OpenCitations bibliographic resource ID

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21559407%20AND%20SRC:MED&resulttype=core&format=json

31 January 2020

2011PLoSO...619339Q

0 references

OpenCitations bibliographic resource ID

1 reference

Consolidated OpenCitations Corpus – April 2017

OpenCitations bibliographic resource ID

PMC publication ID

2 references

Consolidated OpenCitations Corpus – April 2017

OpenCitations bibliographic resource ID

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21559407%20AND%20SRC:MED&resulttype=core&format=json

31 January 2020

PubMed publication ID

2 references

Consolidated OpenCitations Corpus – April 2017

OpenCitations bibliographic resource ID

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21559407%20AND%20SRC:MED&resulttype=core&format=json

31 January 2020

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