(Q28480411)

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Charge profile analysis reveals that activation of pro-apoptotic regulators Bax and Bak relies on charge transfer mediated allosteric regulation

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scholarly article

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Charge profile analysis reveals that activation of pro-apoptotic regulators Bax and Bak relies on charge transfer mediated allosteric regulation (English)

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apoptotic process

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Radka Svobodová Vařeková

2

object named as

Radka Svobodová Vařeková

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Crina-Maria Ionescu

1

object named as

Crina-Maria Ionescu

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5

object named as

Jaroslav Koča

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author name string

Jochen H M Prehn

3

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Heinrich J Huber

4

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publication date

2012

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PLOS Computational Biology

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8

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6

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e1002565

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copyright license

Creative Commons Attribution 4.0 International

14 June 2012

1 reference

April 2022 Public Data File from Crossref

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Proteins move! Protein dynamics and long-range allostery in cell signaling

1 reference

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19 March 2017

Membrane binding by tBid initiates an ordered series of events culminating in membrane permeabilization by Bax

1 reference

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19 March 2017

BAX activation is initiated at a novel interaction site

1 reference

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19 March 2017

Clustal W and Clustal X version 2.0

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19 March 2017

Apoptosis initiated when BH3 ligands engage multiple Bcl-2 homologs, not Bax or Bak

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19 March 2017

The X-ray structure of a BAK homodimer reveals an inhibitory zinc binding site

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3375244

19 March 2017

A stapled BID BH3 helix directly binds and activates BAX

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3375244

19 March 2017

Proapoptotic BAX and BAK: a requisite gateway to mitochondrial dysfunction and death

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3375244

19 March 2017

Structure of Bax: coregulation of dimer formation and intracellular localization

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19 March 2017

Conformation of the Bax C-terminus regulates subcellular location and cell death

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3375244

19 March 2017

Movement of Bax from the cytosol to mitochondria during apoptosis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3375244

19 March 2017

Cytosol-to-membrane redistribution of Bax and Bcl-X(L) during apoptosis

1 reference

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19 March 2017

VMD: visual molecular dynamics

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19 March 2017

Bcl-2 heterodimerizes in vivo with a conserved homolog, Bax, that accelerates programmed cell death

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3375244

19 March 2017

VDAC2 inhibits BAK activation and mitochondrial apoptosis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3375244

19 March 2017

Bid induces the oligomerization and insertion of Bax into the outer mitochondrial membrane

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3375244

19 March 2017

Mitochondrial membrane permeabilization in cell death

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3375244

7 April 2017

Mitochondria and cell death: outer membrane permeabilization and beyond

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3375244

7 April 2017

BH3 domains of BH3-only proteins differentially regulate Bax-mediated mitochondrial membrane permeabilization both directly and indirectly

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3375244

7 April 2017

Distinct BH3 domains either sensitize or activate mitochondrial apoptosis, serving as prototype cancer therapeutics

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3375244

7 April 2017

Molecular biology of Bax and Bak activation and action

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3375244

29 September 2017

Inhibition of Bak activation by VDAC2 is dependent on the Bak transmembrane anchor

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3375244

29 September 2017

VDAC2 is required for truncated BID-induced mitochondrial apoptosis by recruiting BAK to the mitochondria

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3375244

29 September 2017

Single-cell quantification of Bax activation and mathematical modelling suggest pore formation on minimal mitochondrial Bax accumulation.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3375244

29 September 2017

Bax activation by Bim?

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3375244

29 September 2017

TRITON: a graphical tool for ligand-binding protein engineering

1 reference

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29 September 2017

An efficient method for calculating atomic charges of peptides and proteins from electronic populations

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3375244

29 September 2017

Allostery: absence of a change in shape does not imply that allostery is not at play

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3375244

29 September 2017

How do BCL-2 proteins induce mitochondrial outer membrane permeabilization?

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3375244

29 September 2017

A three-helix homo-oligomerization domain containing BH3 and BH1 is responsible for the apoptotic activity of Bax.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3375244

29 September 2017

Embedded together: the life and death consequences of interaction of the Bcl-2 family with membranes

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3375244

29 September 2017

Bcl-2-family proteins and the role of mitochondria in apoptosis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3375244

29 September 2017

Control of apoptosis in the immune system: Bcl-2, BH3-only proteins and more

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3375244

29 September 2017

Transient binding of an activator BH3 domain to the Bak BH3-binding groove initiates Bak oligomerization

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3375244

2 June 2018

BH3-triggered structural reorganization drives the activation of proapoptotic BAX.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3375244

2 June 2018

Importance of accurate charges in molecular docking: quantum mechanical/molecular mechanical (QM/MM) approach

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2 June 2018

Polarization effects and charge transfer in the KcsA potassium channel.

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21 January 2018

Electronegativity Equalization Method: Parameterization and Validation for Large Sets of Organic, Organohalogene and Organometal Molecule.

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https://api.crossref.org/works/10.1371%2FJOURNAL.PCBI.1002565

21 January 2018

A combined electronegativity equalization and electrostatic potential fit method for the determination of atomic point charges.

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21 January 2018

The electronegativity equalization method and the split charge equilibration applied to organic systems: parametrization, validation, and comparison

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21 January 2018

A modified electronegativity equalization method for fast and accurate calculation of atomic charges in large biological molecules.

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21 January 2018

Optimized and parallelized implementation of the electronegativity equalization method and the atom-bond electronegativity equalization method.

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21 January 2018

To trigger apoptosis, Bak exposes its BH3 domain and homodimerizes via BH3:groove interactions.

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21 January 2018

Toward an alternative hardness kernel matrix structure in the Electronegativity Equalization Method (EEM).

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21 January 2018

Absolute hardness: companion parameter to absolute electronegativity

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21 January 2018

THE NATURE OF THE CHEMICAL BOND. IV. THE ENERGY OF SINGLE BONDS AND THE RELATIVE ELECTRONEGATIVITY OF ATOMS

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21 January 2018

Electronegativity values from thermochemical data

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21 January 2018

Charges for Large Scale Binding Free Energy Calculations with the Linear Interaction Energy Method

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12 December 2020

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An Interpretation of Bond Lengths and a Classification of Bonds

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https://pubmed.ncbi.nlm.nih.gov/22719244

12 December 2020

based on heuristic

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Accurate conformation-dependent molecular electrostatic potentials for high-throughput in silico drug discovery

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12 December 2020

based on heuristic

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Identifiers

10.1371/JOURNAL.PCBI.1002565

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DBLP publication ID

journals/ploscb/IonescuVPHK12

1 reference

DBLP Dataset 2021-01-02

28 January 2021

PMC publication ID

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ResearchGate publication ID

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