(Q28484487)

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Upregulating Noxa by ER stress, celastrol exerts synergistic anti-cancer activity in combination with ABT-737 in human hepatocellular carcinoma cells

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scholarly article

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Upregulating Noxa by ER stress, celastrol exerts synergistic anti-cancer activity in combination with ABT-737 in human hepatocellular carcinoma cells (English)

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hepatocellular carcinoma

1 reference

based on heuristic

object named as

Wei Lu

8

author given names

Wei

author last names

Lu

1 reference

PubMed publication ID

20 October 2023

author name string

Hong Zhu

1

author given names

Hong

author last names

Zhu

1 reference

PubMed publication ID

20 October 2023

Wei Yang

2

author given names

Wei

author last names

Yang

1 reference

PubMed publication ID

20 October 2023

Ling-juan He

3

author given names

Ling-juan

author last names

He

1 reference

PubMed publication ID

20 October 2023

Wan-jing Ding

4

author given names

Wan-jing

author last names

Ding

1 reference

PubMed publication ID

20 October 2023

Lin Zheng

5

author given names

Lin

author last names

Zheng

1 reference

PubMed publication ID

20 October 2023

Si-da Liao

6

author given names

Si-da

author last names

Liao

1 reference

PubMed publication ID

20 October 2023

Ping Huang

7

author given names

Ping

author last names

Huang

1 reference

PubMed publication ID

20 October 2023

Qiao-jun He

9

author given names

Qiao-jun

author last names

He

1 reference

PubMed publication ID

20 October 2023

Bo Yang

10

author given names

Bo

author last names

Yang

1 reference

PubMed publication ID

20 October 2023

language of work or name

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publication date

2012

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0 references

7

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12

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e52333

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copyright license

Creative Commons Attribution 4.0 International

20 December 2012

1 reference

April 2022 Public Data File from Crossref

copyright status

0 references

Bcl-2 inhibitors: targeting mitochondrial apoptotic pathways in cancer therapy

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19 March 2017

ERAD inhibitors integrate ER stress with an epigenetic mechanism to activate BH3-only protein NOXA in cancer cells

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19 March 2017

Structural insights into the degradation of Mcl-1 induced by BH3 domains

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19 March 2017

The Bcl-2 apoptotic switch in cancer development and therapy

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19 March 2017

Quantitative analysis of dose-effect relationships: the combined effects of multiple drugs or enzyme inhibitors

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7 April 2017

Modulation of NOXA and MCL-1 as a strategy for sensitizing melanoma cells to the BH3-mimetic ABT-737.

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29 September 2017

Targeting Bcl-2 family proteins in adult T-cell leukemia/lymphoma: in vitro and in vivo effects of the novel Bcl-2 family inhibitor ABT-737.

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29 September 2017

Paraptosis accompanied by autophagy and apoptosis was induced by celastrol, a natural compound with influence on proteasome, ER stress and Hsp90.

1 reference

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29 September 2017

GDC-0941 sensitizes breast cancer to ABT-737 in vitro and in vivo through promoting the degradation of Mcl-1.

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29 September 2017

Synergistic antitumor activity of gemcitabine and ABT-737 in vitro and in vivo through disrupting the interaction of USP9X and Mcl-1.

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29 September 2017

Cytotoxicity, drug combinability, and biological correlates of ABT-737 against acute lymphoblastic leukemia cells with MLL rearrangement

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29 September 2017

Natural proteasome inhibitor celastrol suppresses androgen-independent prostate cancer progression by modulating apoptotic proteins and NF-kappaB

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3527540

29 September 2017

Suppression of hypoxia-inducible factor 1α (HIF-1α) by tirapazamine is dependent on eIF2α phosphorylation rather than the mTORC1/4E-BP1 pathway

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29 September 2017

The Bcl-xL inhibitor, ABT-737, efficiently induces apoptosis and suppresses growth of hepatoma cells in combination with sorafenib

1 reference

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29 September 2017

HSP90 inhibitor, celastrol, arrests human monocytic leukemia cell U937 at G0/G1 in thiol-containing agents reversible way

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3527540

29 September 2017

Regulation of endoplasmic reticulum stress-induced cell death by ATF4 in neuroectodermal tumor cells

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29 September 2017

Synergistic anti-cancer activity by the combination of TRAIL/APO-2L and celastrol

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3527540

29 September 2017

Characterization of celastrol to inhibit hsp90 and cdc37 interaction

1 reference

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29 September 2017

Hsp90 inhibitors, GA and 17AAG, lead to ER stress-induced apoptosis in rat histiocytoma

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3527540

29 September 2017

Valproic acid enhances bosutinib cytotoxicity in colon cancer cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3527540

29 September 2017

Induction of Noxa sensitizes human colorectal cancer cells expressing Mcl-1 to the small-molecule Bcl-2/Bcl-xL inhibitor, ABT-737.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3527540

29 September 2017

Therapeutic efficacy of ABT-737, a selective inhibitor of BCL-2, in small cell lung cancer

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3527540

29 September 2017

Tumor cell-selective regulation of NOXA by c-MYC in response to proteasome inhibition.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3527540

29 September 2017

IPI-504, a novel and soluble HSP-90 inhibitor, blocks the unfolded protein response in multiple myeloma cells

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3527540

29 September 2017

Gene expression signature-based chemical genomic prediction identifies a novel class of HSP90 pathway modulators

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3527540

29 September 2017

Celastrol, a triterpene extracted from the Chinese "Thunder of God Vine," is a potent proteasome inhibitor and suppresses human prostate cancer growth in nude mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3527540

29 September 2017

Proteasome inhibitors trigger NOXA-mediated apoptosis in melanoma and myeloma cells

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3527540

29 September 2017

Induction of CHOP expression by amino acid limitation requires both ATF4 expression and ATF2 phosphorylation

1 reference

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29 September 2017

Tipping the Noxa/Mcl-1 balance overcomes ABT-737 resistance in chronic lymphocytic leukemia

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3527540

2 June 2018

Mcl-1 down-regulation potentiates ABT-737 lethality by cooperatively inducing Bak activation and Bax translocation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3527540

2 June 2018

Relative level of expression of Bax and Bcl-XL determines the cellular fate of apoptosis/necrosis induced by the overexpression of Bax.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3527540

2 June 2018

Macromolecular substrates for the ICE-like proteases during apoptosis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3527540

2 June 2018

Differential regulation of noxa in normal melanocytes and melanoma cells by proteasome inhibition: therapeutic implications.

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https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0052333

21 January 2018

Molecular Mechanism of Inhibition of the Human Protein Complex Hsp90-Cdc37, a Kinome Chaperone-Cochaperone, by Triterpene Celastrol

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https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0052333

21 January 2018

Mcl-1 is an anti-apoptotic factor for human hepatocellular carcinoma.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3527540

27 November 2018

Synergistic killing of colorectal cancer cells by oxaliplatin and ABT-737

1 reference

https://pubmed.ncbi.nlm.nih.gov/23284992

12 December 2020

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Glycolysis inhibition targets Mcl-1 to restore sensitivity of lymphoma cells to ABT-737-induced apoptosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/23284992

12 December 2020

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inferred from PubMed ID database lookup

Hsp90-Akt phosphorylates ASK1 and inhibits ASK1-mediated apoptosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/23284992

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1371/JOURNAL.PONE.0052333

1 reference

Consolidated OpenCitations Corpus – April 2017

OpenCitations bibliographic resource ID

2012PLoSO...752333Z

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OpenCitations bibliographic resource ID

1 reference

Consolidated OpenCitations Corpus – April 2017

OpenCitations bibliographic resource ID

PMC publication ID

1 reference

Consolidated OpenCitations Corpus – April 2017

OpenCitations bibliographic resource ID

PubMed publication ID

1 reference

Consolidated OpenCitations Corpus – April 2017

OpenCitations bibliographic resource ID

ResearchGate publication ID

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