(Q28536749)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24039569%20AND%20SRC:MED&resulttype=core&format=json

21 February 2020

title

Characterizing changes in the rate of protein-protein dissociation upon interface mutation using hotspot energy and organization (English)

1 reference

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21 February 2020

2

1 reference

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21 February 2020

Iain H Moal

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24039569%20AND%20SRC:MED&resulttype=core&format=json

21 February 2020

Juan Fernández-Recio

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24039569%20AND%20SRC:MED&resulttype=core&format=json

21 February 2020

Paul A. Bates

5

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24039569%20AND%20SRC:MED&resulttype=core&format=json

21 February 2020

author name string

Rudi Agius

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24039569%20AND%20SRC:MED&resulttype=core&format=json

21 February 2020

language of work or name

English

0 references

publication date

5 September 2013

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24039569%20AND%20SRC:MED&resulttype=core&format=json

PLOS Computational Biology

21 February 2020

published in

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24039569%20AND%20SRC:MED&resulttype=core&format=json

21 February 2020

volume

9

1 reference

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21 February 2020

issue

9

1 reference

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21 February 2020

page(s)

e1003216

1 reference

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Creative Commons Attribution 4.0 International

21 February 2020

copyright license

start time

5 September 2013

1 reference

April 2022 Public Data File from Crossref

copyright status

copyrighted

0 references

cites work

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29 September 2017

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Alternative protein-protein interfaces are frequent exceptions

29 September 2017

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29 September 2017

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Understanding cancer mechanisms through network dynamics

29 September 2017

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Protein-protein docking and hot-spot prediction for drug discovery.

29 September 2017

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Computational prediction of protein hot spot residues

29 September 2017

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Kinetic rate constant prediction supports the conformational selection mechanism of protein binding

29 September 2017

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HotRegion: a database of predicted hot spot clusters

29 September 2017

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Hotspot-centric de novo design of protein binders

29 September 2017

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Dynamic modeling and analysis of cancer cellular network motifs

29 September 2017

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Strength of hydrogen bond network takes crucial roles in the dissociation process of inhibitors from the HIV-1 protease binding pocket.

29 September 2017

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Predictions of hot spot residues at protein-protein interfaces using support vector machines.

29 September 2017

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Designing coarse grained-and atom based-potentials for protein-protein docking

29 September 2017

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Protein-protein docking tested in blind predictions: the CAPRI experiment

29 September 2017

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Rate theories for biologists

29 September 2017

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Induced fit, conformational selection and independent dynamic segments: an extended view of binding events

29 September 2017

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29 September 2017

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29 September 2017

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29 September 2017

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Prediction of hot spot residues at protein-protein interfaces by combining machine learning and energy-based methods

29 September 2017

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Cell type-specific importance of ras-c-raf complex association rate constants for MAPK signaling

29 September 2017

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The importance of drug-target residence time.

29 September 2017

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29 September 2017

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29 September 2017

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A feature-based approach to modeling protein-protein interaction hot spots.

29 September 2017

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Fundamental aspects of protein-protein association kinetics

29 September 2017

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DARS (Decoys As the Reference State) potentials for protein-protein docking

29 September 2017

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Mathematical modeling identifies Smad nucleocytoplasmic shuttling as a dynamic signal-interpreting system

29 September 2017

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Correlation between binding rate constants and individual information of E. coli Fis binding sites

29 September 2017

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Identification of hot regions in protein-protein interactions by sequential pattern mining

29 September 2017

1 reference

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Trp/Met/Phe hot spots in protein-protein interactions: potential targets in drug design

29 September 2017

1 reference

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Bridging from molecular simulation to biochemical networks.

29 September 2017

1 reference

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Electrostatic design of protein-protein association rates

29 September 2017

1 reference

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The modular architecture of protein-protein binding interfaces

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3764008

Electrostatically optimized Ras-binding Ral guanine dissociation stimulator mutants increase the rate of association by stabilizing the encounter complex

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3764008

Relationships between structure and interaction kinetics for HIV-1 protease inhibitors

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3764008

Dynamical view of the positions of key side chains in protein-protein recognition

29 September 2017

1 reference

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Folding funnels, binding funnels, and protein function

29 September 2017

1 reference

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Double-mutant cycles: a powerful tool for analyzing protein structure and function

29 September 2017

1 reference

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Additivity of mutant effects assessed by binomial mutagenesis

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3764008

Kinetics and thermodynamics of dimer formation and dissociation for a recombinant humanized monoclonal antibody to vascular endothelial growth factor

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3764008

Human immunodeficiency virus. Mutations in the viral protease that confer resistance to saquinavir increase the dissociation rate constant of the protease-saquinavir complex

3 June 2018

1 reference

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Dissecting the energetics of an antibody-antigen interface by alanine shaving and molecular grafting

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3764008

High-resolution epitope mapping of hGH-receptor interactions by alanine-scanning mutagenesis

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3764008

Protein-protein interaction sites are hot spots for disease-associated nonsynonymous SNPs.

3 June 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PCBI.1003216

Predicting kinetic constants of protein-protein interactions based on structural properties.

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PCBI.1003216

Identification of hot spots within druggable binding regions by computational solvent mapping of proteins.

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PCBI.1003216

KFC2: a knowledge-based hot spot prediction method based on interface solvation, atomic density, and plasticity features.

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PCBI.1003216

Prediction of hot spots in protein interfaces using a random forest model with hybrid features.

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PCBI.1003216

Hot regions in protein--protein interactions: the organization and contribution of structurally conserved hot spot residues

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PCBI.1003216

Protein-protein binding affinity prediction on a diverse set of structures

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PCBI.1003216

Alanine point-mutations in the reactive region of bovine pancreatic trypsin inhibitor: effects on the kinetics and thermodynamics of binding to beta-trypsin and alpha-chymotrypsin.

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PCBI.1003216

Residue-residue potentials with a favorable contact pair term and an unfavorable high packing density term, for simulation and threading.

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PCBI.1003216

Protein folding rates and stability: how much is there beyond size?

21 January 2018

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Crystallographic investigation of peptide binding sites in the N-domain of the ClpA chaperone.

21 January 2018

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Selected-fit versus induced-fit protein binding: kinetic differences and mutational analysis.

21 January 2018

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ASEdb: a database of alanine mutations and their effects on the free energy of binding in protein interactions

21 January 2018

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The binding interface database (BID): a compilation of amino acid hot spots in protein interfaces

21 January 2018

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A simple definition of structural regions in proteins and its use in analyzing interface evolution.

21 January 2018

1 reference

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Binding of the kunitz-type trypsin inhibitor DE-3 fromErythrina caffra seeds to serine proteinases: a comparative study

21 January 2018

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The dynamics of drug-target interactions: drug-target residence time and its impact on efficacy and safety

21 January 2018

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12 December 2020

New insights into the mechanism of protein-protein association

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12 December 2020

Disparate ionic-strength dependencies of on and off rates in protein-protein association

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12 December 2020

Intramolecular cooperativity in a protein binding site assessed by combinatorial shotgun scanning mutagenesis

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12 December 2020

Evaluation of direct and cooperative contributions towards the strength of buried hydrogen bonds and salt bridges

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12 December 2020

Random Forests

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15 December 2022

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Identifiers

DOI

10.1371/JOURNAL.PCBI.1003216

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24039569%20AND%20SRC:MED&resulttype=core&format=json

21 February 2020

0 references

journals/ploscb/AgiusTMFB13

1 reference

DBLP Dataset 2021-01-02

28 January 2021

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24039569%20AND%20SRC:MED&resulttype=core&format=json

21 February 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24039569%20AND%20SRC:MED&resulttype=core&format=json