(Q28539839)

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Targeting the intrinsically disordered structural ensemble of α-synuclein by small molecules as a potential therapeutic strategy for Parkinson's disease

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scholarly article

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Targeting the intrinsically disordered structural ensemble of α-synuclein by small molecules as a potential therapeutic strategy for Parkinson's disease (English)

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Parkinson's disease

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based on heuristic

inferred from title

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based on heuristic

inferred from title

Jennifer A. Johnston

object named as

Jennifer Johnston

15

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Nunilo Cremades

object named as

Nunilo Cremades

5

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Celine Galvagnion

object named as

Celine Galvagnion

9

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Alexander K Buell

object named as

Alexander K Buell

19

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24

object named as

Christopher M Dobson

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Michele Vendruscolo

22

object named as

Michele Vendruscolo

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object named as

Mitali A Tambe

7

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21

object named as

Tuomas P J Knowles

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Carlos W. Bertoncini

4

object named as

Carlos W Bertoncini

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25

object named as

Dale Schenk

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author name string

Gergely Tóth

1

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Shyra J Gardai

2

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Wagner Zago

3

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Susan L Roy

6

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Jean-Christophe Rochet

8

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Gaia Skibinski

10

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Steven Finkbeiner

11

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Michael Bova

12

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Karin Regnstrom

13

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San-San Chiou

14

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Kari Callaway

16

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John P Anderson

17

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Michael F Jobling

18

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Ted A Yednock

20

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John Christodoulou

23

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Lisa McConlogue

26

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language of work or name

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publication date

2014

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9

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2

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e87133

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copyright license

Creative Commons Attribution 4.0 International

14 February 2014

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April 2022 Public Data File from Crossref

copyright status

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Tafamidis, a potent and selective transthyretin kinetic stabilizer that inhibits the amyloid cascade

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Double-knockout mice for alpha- and beta-synucleins: effect on synaptic functions

1 reference

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alpha-Synuclein locus triplication causes Parkinson's disease

1 reference

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Synaptic vesicle depletion correlates with attenuated synaptic responses to prolonged repetitive stimulation in mice lacking alpha-synuclein

1 reference

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Synucleins are developmentally expressed, and alpha-synuclein regulates the size of the presynaptic vesicular pool in primary hippocampal neurons

1 reference

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Rational design of potent human transthyretin amyloid disease inhibitors

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Alpha-synuclein in Lewy bodies

1 reference

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Mutation in the alpha-synuclein gene identified in families with Parkinson's disease

1 reference

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The new mutation, E46K, of alpha-synuclein causes Parkinson and Lewy body dementia

1 reference

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Association between early-onset Parkinson's disease and mutations in the parkin gene

1 reference

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Molecular Pathways of Neurodegeneration in Parkinson's Disease

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Monomeric synucleins generate membrane curvature

1 reference

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Molecular pathogenesis of Parkinson's disease: update

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Direct membrane association drives mitochondrial fission by the Parkinson disease-associated protein alpha-synuclein

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1 reference

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1 reference

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1 reference

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1 reference

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Quantitative determination of the conformational properties of partially folded and intrinsically disordered proteins using NMR dipolar couplings

1 reference

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1 reference

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1 reference

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The interplay between structure and function in intrinsically unstructured proteins.

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3925190

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Release of long-range tertiary interactions potentiates aggregation of natively unstructured alpha-synuclein

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3925190

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Therapeutic approaches to protein-misfolding diseases

1 reference

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1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3925190

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v-SNARE-dependent secretion is required for phagocytosis

1 reference

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NACP, a protein implicated in Alzheimer's disease and learning, is natively unfolded

1 reference

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Phenotypic variation in a large Swedish pedigree due to SNCA duplication and triplication.

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0087133

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Nigrostriatal overabundance of α-synuclein leads to decreased vesicle density and deficits in dopamine release that correlate with reduced motor activity.

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0087133

21 January 2018

Algorithms for computational solvent mapping of proteins

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21 January 2018

Identification of hot spots within druggable binding regions by computational solvent mapping of proteins.

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https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0087133

21 January 2018

Dependence of alpha-synuclein aggregate morphology on solution conditions

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21 January 2018

Evidence for a partially folded intermediate in alpha-synuclein fibril formation

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0087133

21 January 2018

Molecular cloning, genomic organization, chromosomal mapping and subcellular localization of mouse PAP7: a PBR and PKA-RIalpha associated protein.

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0087133

21 January 2018

Mechanisms of DJ-1 neuroprotection in a cellular model of Parkinson's disease

1 reference

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21 January 2018

Phosphorylation of Ser-129 is the dominant pathological modification of alpha-synuclein in familial and sporadic Lewy body disease

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0087133

21 January 2018

NMR characterization of long-range order in intrinsically disordered proteins.

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0087133

21 January 2018

Mapping Long-Range Interactions in α-Synuclein using Spin-Label NMR and Ensemble Molecular Dynamics Simulations

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0087133

21 January 2018

alpha-synuclein gene haplotypes are associated with Parkinson's disease

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0087133

21 January 2018

Familial Mutants of α-Synuclein with Increased Neurotoxicity Have a Destabilized Conformation

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0087133

21 January 2018

Endocytic pathway from the basal plasma membrane to the ruffled border membrane in bone-resorbing osteoclasts

1 reference

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27 November 2018

Identifiers

10.1371/JOURNAL.PONE.0087133

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Consolidated OpenCitations Corpus – April 2017

OpenCitations bibliographic resource ID

2014PLoSO...987133T

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OpenCitations bibliographic resource ID

1 reference

Consolidated OpenCitations Corpus – April 2017

OpenCitations bibliographic resource ID

1 reference

Consolidated OpenCitations Corpus – April 2017

OpenCitations bibliographic resource ID

1 reference

Consolidated OpenCitations Corpus – April 2017

OpenCitations bibliographic resource ID

ResearchGate publication ID

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