(Q28543397)

English

Effects of 5-fluorouracil on morphology, cell cycle, proliferation, apoptosis, autophagy and ROS production in endothelial cells and cardiomyocytes

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scholarly article

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Effects of 5-fluorouracil on morphology, cell cycle, proliferation, apoptosis, autophagy and ROS production in endothelial cells and cardiomyocytes (English)

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1 reference

based on heuristic

inferred from title

apoptotic process

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based on heuristic

inferred from title

Desirée Bartolini

object named as

Desirée Bartolini

4

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object named as

Antonino Bruno

2

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Douglas M. Noonan

object named as

Douglas M Noonan

10

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object named as

Adriana Albini

11

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author name string

Chiara Focaccetti

1

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Elena Magnani

3

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Elisa Principi

5

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Katiuscia Dallaglio

6

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Eraldo O Bucci

7

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Giovanna Finzi

8

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Fausto Sessa

9

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language of work or name

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publication date

2015

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10

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2

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e0115686

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copyright license

Creative Commons Attribution 4.0 International

11 February 2015

1 reference

April 2022 Public Data File from Crossref

copyright status

0 references

Mitochondrial oxidative stress in aging and healthspan

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4324934

19 March 2017

Effects of 5-fluorouracil in nuclear and cellular morphology, proliferation, cell cycle, apoptosis, cytoskeletal and caveolar distribution in primary cultures of smooth muscle cells

1 reference

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19 March 2017

5-fluorouracil induced cardiotoxicity: review of the literature

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4324934

19 March 2017

Design of a novel oral fluoropyrimidine carbamate, capecitabine, which generates 5-fluorouracil selectively in tumours by enzymes concentrated in human liver and cancer tissue

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4324934

19 March 2017

Identification of angiogenic activity and the cloning and expression of platelet-derived endothelial cell growth factor

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4324934

19 March 2017

Acute myocardiotoxicity during 5-fluorouracil therapy

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4324934

19 March 2017

Folate nephropathy occurring during cytotoxic chemotherapy with high-dose folinic acid and 5-fluorouracil

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4324934

19 March 2017

Development by self-digestion: molecular mechanisms and biological functions of autophagy

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7 April 2017

Role of Bcl-2 family proteins in a non-apoptotic programmed cell death dependent on autophagy genes

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7 April 2017

A systematic review of the pathophysiology of 5-fluorouracil-induced cardiotoxicity

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29 September 2017

A mechanistic study on the cardiotoxicity of 5-fluorouracil in vitro and clinical and occupational perspectives

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29 September 2017

Age-associated stresses induce an anti-inflammatory senescent phenotype in endothelial cells

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29 September 2017

Cardiotoxicity in cancer patients treated with 5-fluorouracil or capecitabine: a systematic review of incidence, manifestations and predisposing factors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4324934

29 September 2017

Strategies to prevent and treat cardiovascular risk in cancer patients

1 reference

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29 September 2017

Renal dysfunction and increased risk of cardiotoxicity with trastuzumab therapy: a new challenge in cardio-oncology

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4324934

29 September 2017

5-Fluorouracil induces apoptosis in rat cardiocytes through intracellular oxidative stress.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4324934

29 September 2017

LC-MS/MS method for simultaneous analysis of uracil, 5,6-dihydrouracil, 5-fluorouracil and 5-fluoro-5,6-dihydrouracil in human plasma for therapeutic drug monitoring and toxicity prediction in cancer patients

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4324934

29 September 2017

A senescent cell bystander effect: senescence-induced senescence

1 reference

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29 September 2017

Cardio-oncology in targeting the HER receptor family: the puzzle of different cardiotoxicities of HER2 inhibitors

1 reference

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29 September 2017

Capecitabine in breast cancer: the issue of cardiotoxicity during fluoropyrimidine treatment

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4324934

29 September 2017

Cardiotoxicity of anticancer treatments: what the cardiologist needs to know

1 reference

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29 September 2017

Inhibition of autophagy augments 5-fluorouracil chemotherapy in human colon cancer in vitro and in vivo model

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4324934

29 September 2017

Protection of p53 wild type cells from taxol by nutlin-3 in the combined lung cancer treatment

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4324934

29 September 2017

Cardiotoxicity of anticancer drugs: the need for cardio-oncology and cardio-oncological prevention

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4324934

29 September 2017

Combination of interferon-alpha and 5-fluorouracil inhibits endothelial cell growth directly and by regulation of angiogenic factors released by tumor cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4324934

29 September 2017

Differential activation of cell death and autophagy results in an increased cytotoxic potential for trifluorothymidine compared to 5-fluorouracil in colon cancer cells.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4324934

29 September 2017

Cardiovascular complications of cancer therapy: incidence, pathogenesis, diagnosis, and management

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4324934

29 September 2017

The dual role of thymidine phosphorylase in cancer development and chemotherapy

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4324934

29 September 2017

Inhibition of autophagy by 3-MA enhances the effect of 5-FU-induced apoptosis in colon cancer cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4324934

29 September 2017

Human endothelial function and microvascular ageing.

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4324934

29 September 2017

Vascular endothelial senescence: from mechanisms to pathophysiology.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4324934

29 September 2017

Hypermethylation of the DPYD promoter region is not a major predictor of severe toxicity in 5-fluorouracil based chemotherapy

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4324934

29 September 2017

Accelerated senescence: an emerging role in tumor cell response to chemotherapy and radiation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4324934

29 September 2017

Cardiac toxicity: old and new issues in anti-cancer drugs.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4324934

29 September 2017

Synergistic effect of mTOR inhibitor rapamycin and fluorouracil in inducing apoptosis and cell senescence in hepatocarcinoma cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4324934

29 September 2017

Molecular mechanisms of cardiotoxicity of tyrosine kinase inhibition

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4324934

29 September 2017

Management of hand-foot syndrome induced by capecitabine

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4324934

29 September 2017

Reactive oxygen species in cancer cells: live by the sword, die by the sword.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4324934

29 September 2017

Risk factors and prevention of cardiotoxicity induced by 5-fluorouracil or capecitabine

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4324934

29 September 2017

5-Fluorouracil cardiotoxicity induced by alpha-fluoro-beta-alanine.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4324934

29 September 2017

Capecitabine: a review

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4324934

29 September 2017

Autophagy as a cell death and tumor suppressor mechanism

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4324934

29 September 2017

Molecular mechanisms of N-acetylcysteine actions

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4324934

29 September 2017

Anthracycline-induced cardiac injury using a cardiac cell line: potential for gene therapy studies

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4324934

29 September 2017

Cardiotoxicity of the antiproliferative compound fluorouracil

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4324934

29 September 2017

A drug-induced accelerated senescence (DIAS) is a possibility to study aging in time lapse.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4324934

3 June 2018

Breast cancer drugs dampen vascular functions by interfering with nitric oxide signaling in endothelium.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4324934

3 June 2018

Role of renal function on the development of cardiotoxicity associated with trastuzumab-based adjuvant chemotherapy for early breast cancer

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4324934

3 June 2018

Decreased oxygen transfer capacity of erythrocytes as a cause of 5-fluorouracil related ischemia

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4324934

3 June 2018

Mechanisms of Action and Modulation of Fluorouracil.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4324934

3 June 2018

An alternative molecular mechanism of action of 5-fluorouracil, a potent anticancer drug

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4324934

3 June 2018

Symptomatic cardiotoxicity associated with 5-fluorouracil

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4324934

3 June 2018

In vitro evidence that myocardial ischemia resulting from 5-fluorouracil chemotherapy is due to protein kinase C-mediated vasoconstriction of vascular smooth muscle

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4324934

3 June 2018

Cardiotoxicity of 5-fluorouracil in combination with folinic acid in patients with gastrointestinal cancer

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4324934

3 June 2018

Changes of blood viscosity in patients treated with 5-fluorouracil--a link to cardiotoxicity?

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4324934

3 June 2018

Prinzmetal's angina during 5-fluorouracil chemotherapy

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4324934

3 June 2018

Myocardiotoxicity of 5 Fluorouracil

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4324934

3 June 2018

Pharmacokinetics of 5-fluorouracil assessed with a sensitive mass spectrometric method in patients on a dose escalation schedule

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4324934

3 June 2018

Plasma concentrations of 5-fluorouracil and its metabolites in colon cancer patients

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0115686

21 January 2018

Bioactivation of capecitabine in human liver: involvement of the cytosolic enzyme on 5'-deoxy-5-fluorocytidine formation

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0115686

21 January 2018

Reduced antioxidant defense capacity in myocardial tissue from guinea pigs treated with 5-fluorouracil

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0115686

21 January 2018

Myocardial expression of PDECGF is associated with extracellular matrix remodeling in experimental myocardial infarction in rats

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0115686

21 January 2018

Doxorubicin induces senescence and impairs function of human cardiac progenitor cells.

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0115686

21 January 2018

Cardiotoxicity debated for anthracyclines and trastuzumab in breast cancer

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0115686

21 January 2018

Left and right ventricular effects of anthracycline and trastuzumab chemotherapy: a prospective study using novel cardiac imaging and biochemical markers.

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0115686

21 January 2018

Novel cell death pathways induced by N-(4-hydroxyphenyl)retinamide: therapeutic implications.

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0115686

21 January 2018

Cellular senescence in ageing, age-related disease and longevity.

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0115686

21 January 2018

Calpain-mediated cleavage of Atg5 switches autophagy to apoptosis.

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0115686

21 January 2018

Fluorouracil-induced coronary artery spasm

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0115686

21 January 2018

Chemotherapeutic agents doxorubicin and epirubicin induce a procoagulant phenotype on endothelial cells and blood monocytes

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0115686

21 January 2018

Platelet-derived endothelial cell growth factor/thymidine phosphorylase expression in normal tissues: An immunohistochemical study

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0115686

21 January 2018

A comparison of cardiomyocyte cytotoxic mechanisms for 5-fluorouracil and its pro-drug capecitabine.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4324934

27 November 2018

Cell-cycle distribution and Thymidilate Synthatase (TS) expression correlate with 5-FU resistance in head and neck carcinoma cells.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4324934

27 November 2018

DNA damage is able to induce senescence in tumor cells in vitro and in vivo.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4324934

27 November 2018

The influence of 5-fluorouracil on the endothelium in small arteries. An electron microscopic study in rabbits.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4324934

27 November 2018

Response: Re: Neurocognitive Functioning in Adult Survivors of Childhood Noncentral Nervous System Cancers

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0115686

21 January 2018

Expression of the angiogenic protein, platelet-derived endothelial cell growth factor, in coronary atherosclerotic plaques: In vivo correlation of lesional microvessel density and constrictive vascular remodeling

1 reference

https://pubmed.ncbi.nlm.nih.gov/25671635

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cardiotoxicity of 5-fluorouracil in 1350 patients with no prior history of heart disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/25671635

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cardiac lesions induced by 5-fluorouracil in the rabbit

1 reference

https://pubmed.ncbi.nlm.nih.gov/25671635

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cardiotoxicity of fluoropyrimidines in different schedules of administration: a prospective study

1 reference

https://pubmed.ncbi.nlm.nih.gov/25671635

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cardiotoxicity of antitumor drugs

1 reference

https://pubmed.ncbi.nlm.nih.gov/25671635

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Fluoropyrimidine-associated cardiotoxicity: revisited

1 reference

https://pubmed.ncbi.nlm.nih.gov/25671635

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Evaluation of endothelial cell culture as a model system of vascular ageing

1 reference

https://pubmed.ncbi.nlm.nih.gov/25671635

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Pharmacokinetics of 5-fluorouracil administered orally, by rapid intravenous and by slow infusion

1 reference

https://pubmed.ncbi.nlm.nih.gov/25671635

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The syndrome of 5-fluorouracil cardiotoxicity: an elusive cardiopathy

1 reference

https://pubmed.ncbi.nlm.nih.gov/25671635

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The influence of 5-fluorouracil and methotrexate on vascular endothelium. An experimental study using endothelial cells in the culture

1 reference

https://pubmed.ncbi.nlm.nih.gov/25671635

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1371/JOURNAL.PONE.0115686

1 reference

Consolidated OpenCitations Corpus – April 2017

OpenCitations bibliographic resource ID

2015PLoSO..1015686F

0 references

OpenCitations bibliographic resource ID

1 reference

Consolidated OpenCitations Corpus – April 2017

OpenCitations bibliographic resource ID

PMC publication ID

1 reference

Consolidated OpenCitations Corpus – April 2017

OpenCitations bibliographic resource ID

PubMed publication ID

1 reference

Consolidated OpenCitations Corpus – April 2017

OpenCitations bibliographic resource ID

ResearchGate publication ID

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