(Q28551486)

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Anti-Tumor Activity of Yuanhuacine by Regulating AMPK/mTOR Signaling Pathway and Actin Cytoskeleton Organization in Non-Small Cell Lung Cancer Cells

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scholarly article

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Anti-Tumor Activity of Yuanhuacine by Regulating AMPK/mTOR Signaling Pathway and Actin Cytoskeleton Organization in Non-Small Cell Lung Cancer Cells (English)

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actin cytoskeleton

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non-small-cell lung carcinoma

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inferred from title

author name string

Ji In Kang

1

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Ji-Young Hong

2

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Hye-Jung Lee

3

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Song Yi Bae

4

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Cholomi Jung

5

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Hyen Joo Park

6

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Sang Kook Lee

7

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language of work or name

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publication date

2015

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10

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12

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e0144368

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copyright license

Creative Commons Attribution 4.0 International

11 December 2015

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April 2022 Public Data File from Crossref

copyright status

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mTOR signaling in growth control and disease

1 reference

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Epithelial-mesenchymal transitions in development and disease

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19 March 2017

mTOR complex 2 is required for the development of prostate cancer induced by Pten loss in mice

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4676678

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Epithelial-mesenchymal transition: at the crossroads of development and tumor metastasis

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19 March 2017

TOR signaling in growth and metabolism

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One hundred years of lung cancer

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Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex

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19 March 2017

Mammalian TOR complex 2 controls the actin cytoskeleton and is rapamycin insensitive

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The LKB1 tumor suppressor negatively regulates mTOR signaling

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The AMP-activated protein kinase cascade--a unifying system for energy control

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TSC2 mediates cellular energy response to control cell growth and survival

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TSC2 is phosphorylated and inhibited by Akt and suppresses mTOR signalling

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Lung cancer in never smokers--a different disease

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7 April 2017

Theoretical basis, experimental design, and computerized simulation of synergism and antagonism in drug combination studies

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Ras, PI(3)K and mTOR signalling controls tumour cell growth

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AMP-activated protein kinase: ancient energy gauge provides clues to modern understanding of metabolism

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7 April 2017

The Chinese herb isolate yuanhuacine (YHL-14) induces G2/M arrest in human cancer cells by up-regulating p21 protein expression through an p53 protein-independent cascade

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6"-Debromohamacanthin A, a bis (indole) alkaloid, inhibits angiogenesis by targeting the VEGFR2-mediated PI3K/AKT/mTOR signaling pathways

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Loss of function of e-cadherin in embryonic stem cells and the relevance to models of tumorigenesis

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Perspectives on inhibiting mTOR as a future treatment strategy for hematological malignancies

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Hispidulin potently inhibits human glioblastoma multiforme cells through activation of AMP-activated protein kinase (AMPK).

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Lung cancer: progress in diagnosis, staging and therapy.

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29 September 2017

Daphnane diterpene esters with anti-proliferative activities against human lung cancer cells from Daphne genkwa

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29 September 2017

mTORC1-activated S6K1 phosphorylates Rictor on threonine 1135 and regulates mTORC2 signaling

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29 September 2017

AMP-activated protein kinase: a potential target for the diseases prevention by natural occurring polyphenols

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29 September 2017

Signaling events downstream of mammalian target of rapamycin complex 2 are attenuated in cells and tumors deficient for the tuberous sclerosis complex tumor suppressors

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29 September 2017

Epithelial-mesenchymal transitions: the importance of changing cell state in development and disease.

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29 September 2017

Adenosine 5'-monophosphate-activated protein kinase promotes macrophage polarization to an anti-inflammatory functional phenotype

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29 September 2017

Claudin-1 is a metastasis suppressor and correlates with clinical outcome in lung adenocarcinoma

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29 September 2017

The cell-cell adhesion molecule E-cadherin.

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Natural products in drug discovery

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29 September 2017

The TSC1-TSC2 complex is required for proper activation of mTOR complex 2

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29 September 2017

Mechanisms underlying the metabolic actions of galegine that contribute to weight loss in mice

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29 September 2017

The regulation of AMPK beta1, TSC2, and PTEN expression by p53: stress, cell and tissue specificity, and the role of these gene products in modulating the IGF-1-AKT-mTOR pathways

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29 September 2017

Daphnane diterpene esters isolated from flower buds of Daphne genkwa induce apoptosis in human myelocytic HL-60 cells and suppress tumor growth in Lewis lung carcinoma (LLC)-inoculated mouse model

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29 September 2017

Acetyl-CoA carboxylase alpha is essential to breast cancer cell survival

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29 September 2017

Hypoxia-induced energy stress regulates mRNA translation and cell growth

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29 September 2017

Inhibitory effects of caffeic acid phenethyl ester on cancer cell metastasis mediated by the down-regulation of matrix metalloproteinase expression in human HT1080 fibrosarcoma cells

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29 September 2017

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29 September 2017

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3 June 2018

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21 January 2018

Preparation of yuanhuacine and relative daphne diterpene esters from Daphne genkwa and structure-activity relationship of potent inhibitory activity against DNA topoisomerase I.

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21 January 2018

Evaluation of poly(D,L-lactide-co-glycolide) microspheres for the lung-targeting of yuanhuacine, a novel DNA topoisomerase I inhibitor

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Chemical inhibition of acetyl-CoA carboxylase induces growth arrest and cytotoxicity selectively in cancer cells

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https://pubmed.ncbi.nlm.nih.gov/26656173

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https://pubmed.ncbi.nlm.nih.gov/26656173

12 December 2020

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Identifiers

10.1371/JOURNAL.PONE.0144368

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Consolidated OpenCitations Corpus – April 2017

OpenCitations bibliographic resource ID

2015PLoSO..1044368K

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OpenCitations bibliographic resource ID

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Consolidated OpenCitations Corpus – April 2017

OpenCitations bibliographic resource ID

PMC publication ID

1 reference

Consolidated OpenCitations Corpus – April 2017

OpenCitations bibliographic resource ID

PubMed publication ID

1 reference

Consolidated OpenCitations Corpus – April 2017

OpenCitations bibliographic resource ID

ResearchGate publication ID

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