Wikidata

(Q28557364)

English

Farnesyltransferase, CAAX box, alpha

mammalian protein found in Rattus norvegicus

  • type I protein geranyl-geranyltransferase subunit alpha
  • GGTase-I-alpha
  • Farnesyltransferase, subunit alpha
  • FTase-alpha
  • Fnta
  • CAAX farnesyltransferase subunit alpha
  • protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha
  • ras proteins prenyltransferase subunit alpha
In more languages

Statements

molecular function
protein binding
determination method
IPI
15 references
retrieved
14 February 2019
stated in
TrkB-mediated activation of geranylgeranyltransferase I promotes dendritic morphogenesis
GOA
curator
Rat genome database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04631
determination method
IPI
retrieved
14 February 2019
stated in
Crystallographic analysis reveals that anticancer clinical candidate L-778,123 inhibits protein farnesyltransferase and geranylgeranyltransferase-I by different binding modes
GOA
curator
Rat genome database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04631
determination method
IPI
retrieved
14 February 2019
stated in
Structure of mammalian protein geranylgeranyltransferase type-I
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04631
determination method
IPI
retrieved
14 February 2019
stated in
Crystal structure of protein farnesyltransferase at 2.25 angstrom resolution
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04631
determination method
IPI
retrieved
14 February 2019
stated in
Crystallographic analysis of CaaX prenyltransferases complexed with substrates defines rules of protein substrate selectivity
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04631
determination method
IPI
retrieved
14 February 2019
stated in
TrkB-mediated activation of geranylgeranyltransferase I promotes dendritic morphogenesis
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04631
determination method
IPI
retrieved
14 February 2019
stated in
Crystal structures of the anticancer clinical candidates R115777 (Tipifarnib) and BMS-214662 complexed with protein farnesyltransferase suggest a mechanism of FTI selectivity
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04631
determination method
IPI
retrieved
14 February 2019
stated in
Biochemical and structural studies with prenyl diphosphate analogues provide insights into isoprenoid recognition by protein farnesyl transferase
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04631
determination method
IPI
retrieved
14 February 2019
stated in
The basis for K-Ras4B binding specificity to protein farnesyltransferase revealed by 2 A resolution ternary complex structures
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04631
determination method
IPI
retrieved
14 February 2019
stated in
Crystallographic analysis reveals that anticancer clinical candidate L-778,123 inhibits protein farnesyltransferase and geranylgeranyltransferase-I by different binding modes
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04631
determination method
IPI
retrieved
14 February 2019
stated in
Aryl tetrahydropyridine inhibitors of farnesyltransferase: glycine, phenylalanine and histidine derivatives
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04631
determination method
IPI
retrieved
14 February 2019
stated in
Aryl tetrahydropyridine inhibitors of farnesyltransferase: bioavailable analogues with improved cellular potency
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04631
determination method
IPI
retrieved
14 February 2019
stated in
Discovery of potent imidazole and cyanophenyl containing farnesyltransferase inhibitors with improved oral bioavailability
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04631
determination method
IPI
retrieved
14 February 2019
stated in
Tricyclic farnesyl protein transferase inhibitors: crystallographic and calorimetric studies of structure-activity relationships
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04631
determination method
IPI
retrieved
14 February 2019
stated in
Novel and selective imidazole-containing biphenyl inhibitors of protein farnesyltransferase
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q04631
determination method
IPI
cell component
biological process

Identifiers

 
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                    Retrieved from "https://www.wikidata.org/w/index.php?title=Q28557364&oldid=2023057464"