(Q24644688)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A14609943

31 March 2024

author name string

Jeffrey S. Taylor

1

1 reference

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31 March 2024

T. Scott Reid

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A14609943

31 March 2024

Kimberly L. Terry

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A14609943

31 March 2024

Lorena S. Beese

5

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A14609943

full work available at URL

31 March 2024

language of work or name

English

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publication date

17 November 2003

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https://europepmc.org/articles/pmc275430?pdf=render

file format

Portable Document Format

online access status

open access

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A14609943

https://europepmc.org/articles/PMC275430

31 March 2024

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A14609943

https://europepmc.org/articles/PMC275430?pdf=render

31 March 2024

file format

Portable Document Format

online access status

open access

content deliverer

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A14609943

https://doi.org/10.1093/emboj/cdg571

31 March 2024

online access status

open access

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A14609943

https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1093%2Femboj%2Fcdg571

31 March 2024

1 reference

https://api.crossref.org/works/10.1093/EMBOJ/CDG571

https://onlinelibrary.wiley.com/doi/full/10.1093/emboj/cdg571

31 March 2024

1 reference

https://api.crossref.org/works/10.1093/EMBOJ/CDG571

31 March 2024

0 references

22

0 references

issue

22

0 references

page(s)

5963-74

0 references

cites work

The crystal structure of human protein farnesyltransferase reveals the basis for inhibition by CaaX tetrapeptides and their mimetics

1 reference

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Influence of metal ions on substrate binding and catalytic activity of mammalian protein geranylgeranyltransferase type-I

7 April 2017

1 reference

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Rab geranylgeranyl transferase catalyzes the geranylgeranylation of adjacent cysteines in the small GTPases Rab1A, Rab3A, and Rab5A

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=275430

Rab escort protein-1 is a multifunctional protein that accompanies newly prenylated rab proteins to their target membranes

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=275430

Reaction path of protein farnesyltransferase at atomic resolution

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=275430

Crystal structure of Rab geranylgeranyltransferase at 2.0 A resolution

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=275430

Structure of the Rho family GTP-binding protein Cdc42 in complex with the multifunctional regulator RhoGDI

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=275430

The basis for K-Ras4B binding specificity to protein farnesyltransferase revealed by 2 A resolution ternary complex structures

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=275430

Crystal structure of farnesyl protein transferase complexed with a CaaX peptide and farnesyl diphosphate analogue

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=275430

Phosducin induces a structural change in transducin beta gamma

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=275430

Cocrystal structure of protein farnesyltransferase complexed with a farnesyl diphosphate substrate

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=275430

Protein farnesyltransferase: structure and implications for substrate binding

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=275430

Crystal structure of protein farnesyltransferase at 2.25 angstrom resolution

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=275430

Maximum-likelihood density modification

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=275430

Automated MAD and MIR structure solution

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=275430

Crystallography & NMR System: A New Software Suite for Macromolecular Structure Determination

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=275430

cDNA cloning and expression of rat and human protein geranylgeranyltransferase type-I

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=275430

Endomembrane trafficking of ras: the CAAX motif targets proteins to the ER and Golgi

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=275430

Disruption of the mouse Rce1 gene results in defective Ras processing and mislocalization of Ras within cells

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=275430

Protein prenyltransferases

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=275430

Targeted inactivation of the isoprenylcysteine carboxyl methyltransferase gene causes mislocalization of K-Ras in mammalian cells

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=275430

cDNA cloning of component A of Rab geranylgeranyl transferase and demonstration of its role as a Rab escort protein

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=275430

Properties and kinetic mechanism of recombinant mammalian protein geranylgeranyltransferase type I

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=275430

Rab geranylgeranyl transferase. A multisubunit enzyme that prenylates GTP-binding proteins terminating in Cys-X-Cys or Cys-Cys

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=275430

Inhibition of Rho GTPases with protein prenyltransferase inhibitors prevents leukocyte recruitment to the central nervous system and attenuates clinical signs of disease in an animal model of multiple sclerosis

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=275430

Farnesyl transferase inhibitors: a novel targeted tnerapy for cancer

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=275430

Double prenylation by RabGGTase can proceed without dissociation of the mono-prenylated intermediate

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=275430

Farnesyltransferase and geranylgeranyltransferase I inhibitors and cancer therapy: lessons from mechanism and bench-to-bedside translational studies

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=275430

Single prenyl-binding site on protein prenyl transferases

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=275430

Membrane association and targeting of prenylated Ras-like GTPases

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=275430

Differential prenyl pyrophosphate binding to mammalian protein geranylgeranyltransferase-I and protein farnesyltransferase and its consequence on the specificity of protein prenylation

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=275430

Inhibition of purified p21ras farnesyl:protein transferase by Cys-AAX tetrapeptides

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=275430

A protein geranylgeranyltransferase from bovine brain: implications for protein prenylation specificity

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=275430

Enzymatic modification of proteins with a geranylgeranyl isoprenoid

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=275430

Sequence dependence of protein isoprenylation

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=275430

Protein prenyl transferase activities of Plasmodium falciparum

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=275430

Protein geranylgeranylation, not farnesylation, is required for the G1 to S phase transition in mouse fibroblasts.

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=275430

Inhibition of protein geranylgeranylation and RhoA/RhoA kinase pathway induces apoptosis in human endothelial cells

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=275430

Stereochemical analysis of the reaction catalyzed by human protein geranylgeranyl transferase

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=275430

Inhibiting geranylgeranylation blocks growth and promotes apoptosis in pulmonary vascular smooth muscle cells.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=275430

Substrate binding is required for release of product from mammalian protein farnesyltransferase

28 November 2018

1 reference

12 December 2020

Yeast protein geranylgeranyltransferase type-I: steady-state kinetics and substrate binding

1 reference

12 December 2020

Phosphoisoprenoid Binding Specificity of Geranylgeranyltransferase Type II

1 reference

12 December 2020

Mammalian protein geranylgeranyltransferase-I: substrate specificity, kinetic mechanism, metal requirements, and affinity labeling

1 reference

12 December 2020

Inhibition of farnesyltransferase induces regression of mammary and salivary carcinomas in ras transgenic mice

1 reference

12 December 2020

H-Ras peptide and protein substrates bind protein farnesyltransferase as an ionized thiolate

1 reference

12 December 2020

Easy identification of cDNA clones

1 reference

https://api.crossref.org/works/10.1093%2FEMBOJ%2FCDG571

7 January 2021

The recognition component of the N-end rule pathway

1 reference

https://api.crossref.org/works/10.1093%2FEMBOJ%2FCDG571

7 January 2021

UBC1 encodes a novel member of an essential subfamily of yeast ubiquitin-conjugating enzymes involved in protein degradation.

1 reference

https://api.crossref.org/works/10.1093%2FEMBOJ%2FCDG571

7 January 2021

Role of potentially charged transmembrane residues in targeting proteins for retention and degradation within the endoplasmic reticulum

1 reference

https://api.crossref.org/works/10.1093%2FEMBOJ%2FCDG571

7 January 2021

Degradation of subunits of the Sec61p complex, an integral component of the ER membrane, by the ubiquitin-proteasome pathway.

1 reference

https://api.crossref.org/works/10.1093%2FEMBOJ%2FCDG571

7 January 2021

A simple method for displaying the hydropathic character of a protein

1 reference

https://api.crossref.org/works/10.1093%2FEMBOJ%2FCDG571

7 January 2021

10 Yeast promoters and lacZ fusions designed to study expression of cloned genes in yeast

1 reference

https://api.crossref.org/works/10.1093%2FEMBOJ%2FCDG571

7 January 2021

In vitro mutagenesis and plasmid shuffling: from cloned gene to mutant yeast

1 reference

https://api.crossref.org/works/10.1093%2FEMBOJ%2FCDG571

7 January 2021

The yeast polyubiquitin gene is essential for resistance to high temperatures, starvation, and other stresses

1 reference

https://api.crossref.org/works/10.1093%2FEMBOJ%2FCDG571

7 January 2021

Colocalized transmembrane determinants for ER degradation and subunit assembly explain the intracellular fate of TCR chains

1 reference

https://api.crossref.org/works/10.1093%2FEMBOJ%2FCDG571

7 January 2021

In vivo degradation of a transcriptional regulator: the yeast alpha 2 repressor

1 reference

https://api.crossref.org/works/10.1093%2FEMBOJ%2FCDG571

7 January 2021

https://api.crossref.org/works/10.1093%2FEMBOJ%2FCDG571

1 reference

7 January 2021

Multiple ubiquitin-conjugating enzymes participate in the in vivo degradation of the yeast MAT alpha 2 repressor

1 reference

https://api.crossref.org/works/10.1093%2FEMBOJ%2FCDG571

7 January 2021

The ubiquitin-proteasome proteolytic pathway

1 reference

https://api.crossref.org/works/10.1093%2FEMBOJ%2FCDG571

7 January 2021

Selective protein degradation: a journey's end within the proteasome

1 reference

https://api.crossref.org/works/10.1093%2FEMBOJ%2FCDG571

7 January 2021

Sequence features that correlate with MHC restriction

1 reference

https://api.crossref.org/works/10.1093%2FEMBOJ%2FCDG571

7 January 2021

Ubiquitin, proteasomes, and the regulation of intracellular protein degradation

1 reference

https://api.crossref.org/works/10.1093%2FEMBOJ%2FCDG571

7 January 2021

Ubiquitination of a yeast plasma membrane receptor signals its ligand-stimulated endocytosis

1 reference

https://api.crossref.org/works/10.1093%2FEMBOJ%2FCDG571

7 January 2021

Protein degradation or regulation: Ub the judge

1 reference

https://api.crossref.org/works/10.1093%2FEMBOJ%2FCDG571

7 January 2021

A novel mechanism for regulating activity of a transcription factor that controls the unfolded protein response

1 reference

https://api.crossref.org/works/10.1093%2FEMBOJ%2FCDG571

7 January 2021

Proteolysis: The proteasome: a protein-degrading organelle?

1 reference

https://api.crossref.org/works/10.1093%2FEMBOJ%2FCDG571

7 January 2021

PEST sequences and regulation by proteolysis

1 reference

https://api.crossref.org/works/10.1093%2FEMBOJ%2FCDG571

7 January 2021

The Pas2 protein essential for peroxisome biogenesis is related to ubiquitin-conjugating enzymes

1 reference

https://api.crossref.org/works/10.1093%2FEMBOJ%2FCDG571

7 January 2021

Resistance to cadmium mediated by ubiquitin-dependent proteolysis

1 reference

https://api.crossref.org/works/10.1093%2FEMBOJ%2FCDG571

7 January 2021

A protein translocation defect linked to ubiquitin conjugation at the endoplasmic reticulum

1 reference

https://api.crossref.org/works/10.1093%2FEMBOJ%2FCDG571

7 January 2021

The yeast DOA4 gene encodes a deubiquitinating enzyme related to a product of the human tre-2 oncogene

1 reference

https://api.crossref.org/works/10.1093%2FEMBOJ%2FCDG571

7 January 2021

Role of a ubiquitin-conjugating enzyme in degradation of S- and M-phase cyclins

1 reference

https://api.crossref.org/works/10.1093%2FEMBOJ%2FCDG571

7 January 2021

Sec61-mediated transfer of a membrane protein from the endoplasmic reticulum to the proteasome for destruction

1 reference

https://api.crossref.org/works/10.1093%2FEMBOJ%2FCDG571

7 January 2021

Mutant analysis links the translocon and BiP to retrograde protein transport for ER degradation

1 reference

https://api.crossref.org/works/10.1093%2FEMBOJ%2FCDG571

7 January 2021

Reversible phosphorylation controls the activity of cyclosome-associated cyclin-ubiquitin ligase

1 reference

https://api.crossref.org/works/10.1093%2FEMBOJ%2FCDG571

7 January 2021

A proteolytic pathway that recognizes ubiquitin as a degradation signal

1 reference

https://api.crossref.org/works/10.1093%2FEMBOJ%2FCDG571

7 January 2021

Role of a peptide tagging system in degradation of proteins synthesized from damaged messenger RNA

1 reference

https://api.crossref.org/works/10.1093%2FEMBOJ%2FCDG571

7 January 2021

Rapid degradation of the G1 cyclin Cln2 induced by CDK-dependent phosphorylation

1 reference

https://api.crossref.org/works/10.1093%2FEMBOJ%2FCDG571

7 January 2021

ER degradation of a misfolded luminal protein by the cytosolic ubiquitin-proteasome pathway

1 reference

https://api.crossref.org/works/10.1093%2FEMBOJ%2FCDG571

7 January 2021

https://api.crossref.org/works/10.1093%2FEMBOJ%2FCDG571

1 reference

7 January 2021

How proteolysis drives the cell cycle

1 reference

https://api.crossref.org/works/10.1093%2FEMBOJ%2FCDG571

7 January 2021

Role of Cue1p in ubiquitination and degradation at the ER surface

1 reference

https://api.crossref.org/works/10.1093%2FEMBOJ%2FCDG571

7 January 2021

In vivo half-life of a protein is a function of its amino-terminal residue

1 reference

https://api.crossref.org/works/10.1093%2FEMBOJ%2FCDG571

7 January 2021

Heat-inducible degron: a method for constructing temperature-sensitive mutants.

1 reference

https://api.crossref.org/works/10.1093%2FEMBOJ%2FCDG571

7 January 2021

p34Cdc28-mediated control of Cln3 cyclin degradation

1 reference

https://api.crossref.org/works/10.1093%2FEMBOJ%2FCDG571

7 January 2021

Synthetic signals for ubiquitin-dependent proteolysis

1 reference

https://api.crossref.org/works/10.1093%2FEMBOJ%2FCDG571

7 January 2021

The ubiquitin system for protein degradation

1 reference

https://api.crossref.org/works/10.1093%2FEMBOJ%2FCDG571

7 January 2021

Ubiquitin-dependent protein degradation

1 reference

https://api.crossref.org/works/10.1093%2FEMBOJ%2FCDG571

7 January 2021

Identifiers

0 references

0 references