(Q28571389)

31 January 2017

title

Focal adhesion kinase as a RhoA-activable signaling scaffold mediating Akt activation and cardiomyocyte protection (English)

1 reference

31 January 2017

Dominic P. Del Re

1

1 reference

31 January 2017

Shigeki Miyamoto

series ordinal

2

1 reference

31 January 2017

Joan Heller Brown

series ordinal

3

1 reference

31 January 2017

language of work or name

English

0 references

publication date

19 December 2008

1 reference

Journal of Biological Chemistry

31 January 2017

published in

1 reference

31 January 2017

volume

283

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31 January 2017

issue

51

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31 January 2017

page(s)

35622–35629

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Rho GTPases and actin dynamics in membrane protrusions and vesicle trafficking

31 January 2017

cites work

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19 March 2017

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MAP kinase- and Rho-dependent signals interact to regulate gene expression but not actin morphology in cardiac muscle cells

19 March 2017

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19 March 2017

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19 March 2017

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Disruption of ROCK1 gene attenuates cardiac dilation and improves contractile function in pathological cardiac hypertrophy

7 April 2017

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Myocyte-restricted focal adhesion kinase deletion attenuates pressure overload-induced hypertrophy

29 September 2017

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The Rac and Rho hall of fame: a decade of hypertrophic signaling hits

29 September 2017

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Physiological role of ROCKs in the cardiovascular system

29 September 2017

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Decreased perivascular fibrosis but not cardiac hypertrophy in ROCK1+/- haploinsufficient mice

29 September 2017

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Clinging to life: cell to matrix adhesion and cell survival

29 September 2017

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RhoA/ROCK signaling is critical to FAK activation by cyclic stretch in cardiac myocytes.

29 September 2017

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Regulation of PTEN by Rho small GTPases

29 September 2017

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Src family kinases, key regulators of signal transduction

29 September 2017

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Inhibition of Rho-kinase leads to rapid activation of phosphatidylinositol 3-kinase/protein kinase Akt and cardiovascular protection.

29 September 2017

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Positional Control of Cell Fate Through Joint Integrin/Receptor Protein Kinase Signaling

29 September 2017

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Rho GTPase/Rho kinase negatively regulates endothelial nitric oxide synthase phosphorylation through the inhibition of protein kinase B/Akt in human endothelial cells

29 September 2017

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Marked perinatal lethality and cellular signaling deficits in mice null for the two sphingosine 1-phosphate (S1P) receptors, S1P(2)/LP(B2)/EDG-5 and S1P(3)/LP(B3)/EDG-3.

29 September 2017

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Assembly and mechanosensory function of focal contacts

29 September 2017

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Akt promotes survival of cardiomyocytes in vitro and protects against ischemia-reperfusion injury in mouse heart.

29 September 2017

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FAK is the upstream signal protein of the phosphatidylinositol 3-kinase-Akt survival pathway in hydrogen peroxide-induced apoptosis of a human glioblastoma cell line

29 September 2017

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A balance of signaling by Rho family small GTPases RhoA, Rac1 and Cdc42 coordinates cytoskeletal morphology but not cell survival

29 September 2017

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Rho-regulated signals induce apoptosis in vitro and in vivo by a p53-independent, but Bcl2 dependent pathway.

29 September 2017

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Inhibition of pp125FAK in cultured fibroblasts results in apoptosis

29 September 2017

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29 September 2017

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Control of adhesion-dependent cell survival by focal adhesion kinase

29 September 2017

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A mechanism for regulation of the adhesion-associated proteintyrosine kinase pp125FAK.

29 September 2017

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Association of phosphatidylinositol 3-kinase, via the SH2 domains of p85, with focal adhesion kinase in polyoma middle t-transformed fibroblasts.

29 September 2017

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The extracellular matrix as a cell survival factor

29 September 2017

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Association of focal adhesion kinase with its potential substrate phosphatidylinositol 3-kinase

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2602897

S1P1 receptor localization confers selectivity for Gi-mediated cAMP and contractile responses

29 September 2017

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GFP-FRNK disrupts focal adhesions and induces anoikis in neonatal rat ventricular myocytes.

3 June 2018

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Y-27632, an inhibitor of Rho-associated kinases, prevents tyrosine phosphorylation of focal adhesion kinase and paxillin induced by bombesin: dissociation from tyrosine phosphorylation of p130(CAS).

3 June 2018

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Rho is required for Galphaq and alpha1-adrenergic receptor signaling in cardiomyocytes. Dissociation of Ras and Rho pathways

3 June 2018

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Phosphorylation of tyrosine 397 in focal adhesion kinase is required for binding phosphatidylinositol 3-kinase

3 June 2018

1 reference

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Lysophosphatidic acid induces tyrosine phosphorylation and activation of MAP-kinase and focal adhesion kinase in cultured Swiss 3T3 cells

3 June 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2602897

Botulinum C3 exoenzyme blocks the tyrosine phosphorylation of p125FAK and paxillin induced by bombesin and endothelin

3 June 2018

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Inhibition of protein geranylgeranylation and RhoA/RhoA kinase pathway induces apoptosis in human endothelial cells

3 June 2018

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Anti-apoptotic effects of muscarinic receptor activation are mediated by Rho kinase

21 January 2018

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Constitutively active Galphaq and Galpha13 trigger apoptosis through different pathways

21 January 2018

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Regulation of Apoptosis by α-Subunits of G12 and G13 Proteins via Apoptosis Signal-regulating Kinase-1

21 January 2018

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RhoA/Rho kinase up-regulate Bax to activate a mitochondrial death pathway and induce cardiomyocyte apoptosis

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M804036200

Akt activation preserves cardiac function and prevents injury after transient cardiac ischemia in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M804036200

Tyrosine kinase and c-Jun NH2-terminal kinase mediate hypertrophic responses to prostaglandin F2alpha in cultured neonatal rat ventricular myocytes

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M804036200

Initiation and transduction of stretch-induced RhoA and Rac1 activation through caveolae: cytoskeletal regulation of ERK translocation

21 January 2018

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The low molecular weight GTPase Rho regulates myofibril formation and organization in neonatal rat ventricular myocytes. Involvement of Rho kinase

21 January 2018

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Statin prevents tissue factor expression in human endothelial cells: role of Rho/Rho-kinase and Akt pathways

21 January 2018

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Long-term inhibition of Rho-kinase suppresses left ventricular remodeling after myocardial infarction in mice

21 January 2018

1 reference

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Inhibition of Rho-kinase protects the heart against ischemia/reperfusion injury.

21 January 2018

1 reference

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Sphingosine 1-phosphate S1P2 and S1P3 receptor-mediated Akt activation protects against in vivo myocardial ischemia-reperfusion injury

21 January 2018

1 reference

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Endothelin-induced cardiac myocyte hypertrophy: role for focal adhesion kinase

27 November 2018

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12 December 2020

Early activation of the multicomponent signaling complex associated with focal adhesion kinase induced by pressure overload in the rat heart

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12 December 2020

Angiotensin II activates RhoA in cardiac myocytes: a critical role of RhoA in angiotensin II-induced premyofibril formation

1 reference

12 December 2020

Targeting Focal Adhesion Kinase With Small Interfering RNA Prevents and Reverses Load-Induced Cardiac Hypertrophy in Mice

1 reference

12 December 2020

The COOH-terminal domain of the focal adhesion kinase induces loss of adhesion and cell death in human tumor cells

1 reference

12 December 2020

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12 December 2020

Targeted deletion of ROCK1 protects the heart against pressure overload by inhibiting reactive fibrosis

1 reference

12 December 2020