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Pax6 is crucial for β-cell function, insulin biosynthesis, and glucose-induced insulin secretion
scientific journal article
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instance of
scholarly article
1 reference
stated in
PubMed
PubMed ID
22403172
retrieved
31 January 2017
title
Pax6 is crucial for β-cell function, insulin biosynthesis, and glucose-induced insulin secretion
(English)
1 reference
stated in
PubMed
PubMed ID
22403172
retrieved
31 January 2017
main subject
glucose
0 references
preproinsulin
1 reference
based on heuristic
inferred from title
cell function
0 references
author name string
Yvan Gosmain
series ordinal
1
1 reference
stated in
PubMed
PubMed ID
22403172
retrieved
31 January 2017
Liora S. Katz
series ordinal
2
1 reference
stated in
PubMed
PubMed ID
22403172
retrieved
31 January 2017
Mounia Heddad Masson
series ordinal
3
1 reference
stated in
PubMed
PubMed ID
22403172
retrieved
31 January 2017
Claire Cheyssac
series ordinal
4
1 reference
stated in
PubMed
PubMed ID
22403172
retrieved
31 January 2017
Caroline Poisson
series ordinal
5
1 reference
stated in
PubMed
PubMed ID
22403172
retrieved
31 January 2017
Jacques Philippe
series ordinal
6
1 reference
stated in
PubMed
PubMed ID
22403172
retrieved
31 January 2017
publication date
1 April 2012
1 reference
stated in
PubMed
PubMed ID
22403172
retrieved
31 January 2017
published in
Molecular Endocrinology
1 reference
stated in
PubMed
PubMed ID
22403172
retrieved
31 January 2017
volume
26
1 reference
stated in
PubMed
PubMed ID
22403172
retrieved
31 January 2017
issue
4
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stated in
PubMed
PubMed ID
22403172
retrieved
31 January 2017
page(s)
696–709
1 reference
stated in
PubMed
PubMed ID
22403172
retrieved
31 January 2017
cites work
Pax6 controls the expression of critical genes involved in pancreatic {alpha} cell differentiation and function
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5417143
retrieved
26 May 2017
FoxA2, Nkx2.2, and PDX-1 regulate islet beta-cell-specific mafA expression through conserved sequences located between base pairs -8118 and -7750 upstream from the transcription start site
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5417143
retrieved
26 May 2017
The Nkx6.1 homeodomain transcription factor suppresses glucagon expression and regulates glucose-stimulated insulin secretion in islet beta cells
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5417143
retrieved
26 May 2017
The MafA transcription factor appears to be responsible for tissue-specific expression of insulin
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5417143
retrieved
26 May 2017
Members of the large Maf transcription family regulate insulin gene transcription in islet beta cells
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5417143
retrieved
26 May 2017
Conserved sequences in a tissue-specific regulatory region of the pdx-1 gene mediate transcription in Pancreatic beta cells: role for hepatocyte nuclear factor 3 beta and Pax6
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5417143
retrieved
26 May 2017
Insulin gene transcription is mediated by interactions between the p300 coactivator and PDX-1, BETA2, and E47.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5417143
retrieved
26 May 2017
PAX6 mutation as a genetic factor common to aniridia and glucose intolerance
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5417143
retrieved
26 May 2017
Mice lacking the homeodomain transcription factor Nkx2.2 have diabetes due to arrested differentiation of pancreatic beta cells
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5417143
retrieved
26 May 2017
Diabetes, defective pancreatic morphogenesis, and abnormal enteroendocrine differentiation in BETA2/neuroD-deficient mice
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5417143
retrieved
26 May 2017
Independent requirement for ISL1 in formation of pancreatic mesenchyme and islet cells
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5417143
retrieved
26 May 2017
Pax-6, a murine paired box gene, is expressed in the developing CNS
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5417143
retrieved
26 May 2017
Mafa expression enhances glucose-responsive insulin secretion in neonatal rat beta cells
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5417143
retrieved
29 September 2017
Islet beta-cell-specific MafA transcription requires the 5'-flanking conserved region 3 control domain.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5417143
retrieved
29 September 2017
PDX1 deficiency causes mitochondrial dysfunction and defective insulin secretion through TFAM suppression
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5417143
retrieved
29 September 2017
Pax6 regulates the proglucagon processing enzyme PC2 and its chaperone 7B2.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5417143
retrieved
29 September 2017
The role of incretins in glucose homeostasis and diabetes treatment
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5417143
retrieved
29 September 2017
Pax6 and Pdx1 are required for production of glucose-dependent insulinotropic polypeptide in proglucagon-expressing L cells
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5417143
retrieved
29 September 2017
Preferential reduction of beta cells derived from Pax6-MafB pathway in MafB deficient mice.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5417143
retrieved
29 September 2017
Glucolipotoxicity: fuel excess and beta-cell dysfunction.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5417143
retrieved
29 September 2017
Pax-6 and c-Maf functionally interact with the alpha-cell-specific DNA element G1 in vivo to promote glucagon gene expression
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5417143
retrieved
29 September 2017
MAFA controls genes implicated in insulin biosynthesis and secretion
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5417143
retrieved
29 September 2017
Transcription factor cycling on the insulin promoter
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5417143
retrieved
29 September 2017
Palmitate inhibits insulin gene expression by altering PDX-1 nuclear localization and reducing MafA expression in isolated rat islets of Langerhans
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5417143
retrieved
29 September 2017
MafA is a key regulator of glucose-stimulated insulin secretion
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5417143
retrieved
29 September 2017
Inhibition of insulin gene expression by long-term exposure of pancreatic beta cells to palmitate is dependent on the presence of a stimulatory glucose concentration
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5417143
retrieved
29 September 2017
Transcriptional activation of the GLUT2 gene by the IPF-1/STF-1/IDX-1 homeobox factor
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5417143
retrieved
29 September 2017
Pax-QNR/Pax-6, a paired box- and homeobox-containing gene expressed in neurons, is also expressed in pancreatic endocrine cells
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5417143
retrieved
29 September 2017
Homologous DNA sequences and cellular factors are implicated in the control of glucagon and insulin gene expression
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5417143
retrieved
29 September 2017
Genetic analysis reveals that PAX6 is required for normal transcription of pancreatic hormone genes and islet development
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5417143
retrieved
3 June 2018
Pax6 haploinsufficiency causes abnormal metabolic homeostasis by down-regulating glucagon-like peptide 1 in mice
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5417143
retrieved
27 November 2018
Paired box 6 (PAX6) regulates glucose metabolism via proinsulin processing mediated by prohormone convertase 1/3 (PC1/3).
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5417143
retrieved
27 November 2018
Chronic hyperglycemia, independent of plasma lipid levels, is sufficient for the loss of beta-cell differentiation and secretory function in the db/db mouse model of diabetes
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5417143
retrieved
27 November 2018
A case of novel de novo paired box gene 6 (PAX6) mutation with early-onset diabetes mellitus and aniridia
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5417143
retrieved
27 November 2018
Conditional inactivation of Pax6 in the pancreas causes early onset of diabetes
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5417143
retrieved
27 November 2018
Transcription factor occupancy of the insulin gene in vivo. Evidence for direct regulation by Nkx2.2.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5417143
retrieved
27 November 2018
Reduction in pancreatic transcription factor PDX-1 impairs glucose-stimulated insulin secretion
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5417143
retrieved
27 November 2018
The Tet-On system in transgenic mice: inhibition of the mouse pdx-1 gene activity by antisense RNA expression in pancreatic beta-cells
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5417143
retrieved
27 November 2018
Isolation of rat pancreatic islets by ductal injection of collagenase
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/22403172
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Chronic hyperglycemia triggers loss of pancreatic beta cell differentiation in an animal model of diabetes
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/22403172
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Fatty acids decrease IDX-1 expression in rat pancreatic islets and reduce GLUT2, glucokinase, insulin, and somatostatin levels
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/22403172
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Pax6 is required for differentiation of glucagon-producing α-cells in mouse pancreas
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/22403172
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Identifiers
DOI
10.1210/ME.2011-1256
1 reference
stated in
Consolidated OpenCitations Corpus – April 2017
OpenCitations bibliographic resource ID
1593095
OpenCitations bibliographic resource ID
1593095
1 reference
stated in
Consolidated OpenCitations Corpus – April 2017
OpenCitations bibliographic resource ID
1593095
PMCID
5417143
0 references
PubMed ID
22403172
1 reference
stated in
Consolidated OpenCitations Corpus – April 2017
OpenCitations bibliographic resource ID
1593095
ResearchGate publication ID
221689087
0 references
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