(Q28574797)

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Inhibition of EGFR/MAPK signaling reduces microglial inflammatory response and the associated secondary damage in rats after spinal cord injury

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scholarly article

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31 January 2017

Inhibition of EGFR/MAPK signaling reduces microglial inflammatory response and the associated secondary damage in rats after spinal cord injury (English)

1 reference

31 January 2017

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5

object named as

Qiang Zhang

1 reference

31 January 2017

author name string

Wen-Sheng Qu

1

1 reference

31 January 2017

Dai-Shi Tian

2

1 reference

31 January 2017

Zhi-Bao Guo

3

1 reference

31 January 2017

Jun Fang

4

1 reference

31 January 2017

Zhi-Yuan Yu

6

1 reference

31 January 2017

Min-Jie Xie

7

1 reference

31 January 2017

Hua-Qiu Zhang

8

1 reference

31 January 2017

Jia-Gao Lü

9

1 reference

31 January 2017

Wei Wang

10

1 reference

31 January 2017

publication date

23 July 2012

1 reference

31 January 2017

Journal of Neuroinflammation

1 reference

31 January 2017

9

1 reference

31 January 2017

178

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31 January 2017

https://scigraph.springernature.com/pub.10.1186/1742-2094-9-178

0 references

Quantitative analysis of cellular inflammation after traumatic spinal cord injury: evidence for a multiphasic inflammatory response in the acute to chronic environment

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3418570

17 March 2017

Epidermal growth factor receptor inhibition modulates the microenvironment by vascular normalization to improve chemotherapy and radiotherapy efficacy

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3418570

17 March 2017

Inhibiting epidermal growth factor receptor improves structural, locomotor, sensory, and bladder recovery from experimental spinal cord injury.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3418570

17 March 2017

Interleukin-1 beta induction of neuron apoptosis depends on p38 mitogen-activated protein kinase activity after spinal cord injury

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3418570

17 March 2017

Signal transduction by the c-Jun N-terminal kinase (JNK)--from inflammation to development

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3418570

17 March 2017

Pro-inflammatory cytokines and lipopolysaccharide induce changes in cell morphology, and upregulation of ERK1/2, iNOS and sPLA₂-IIA expression in astrocytes and microglia.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3418570

29 September 2017

Microglial p38α MAPK is a key regulator of proinflammatory cytokine up-regulation induced by toll-like receptor (TLR) ligands or beta-amyloid (Aβ)

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3418570

29 September 2017

Enhanced epidermal growth factor, hepatocyte growth factor, and vascular endothelial growth factor expression in tuberous sclerosis complex

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3418570

29 September 2017

The alternative and terminal pathways of complement mediate post-traumatic spinal cord inflammation and injury

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3418570

29 September 2017

Role of microglia in neurotrauma

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3418570

29 September 2017

The effect of epidermal growth factor in the injured brain after trauma in rats

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3418570

29 September 2017

FoxO transcription factors promote autophagy in cardiomyocytes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3418570

29 September 2017

A straight alley version of the BBB locomotor scale

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3418570

29 September 2017

Resection of glial scar following spinal cord injury

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3418570

29 September 2017

Inflammation: beneficial or detrimental after spinal cord injury?

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3418570

29 September 2017

Methanol extract of Ficus leaf inhibits the production of nitric oxide and proinflammatory cytokines in LPS-stimulated microglia via the MAPK pathway

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3418570

29 September 2017

EGFR inhibitor-mediated apoptosis in solid tumors.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3418570

29 September 2017

Inflammation and brain edema: new insights into the role of chemokines and their receptors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3418570

29 September 2017

Preclinical analysis of the analinoquinazoline AG1478, a specific small molecule inhibitor of EGF receptor tyrosine kinase.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3418570

29 September 2017

EGFR activation mediates inhibition of axon regeneration by myelin and chondroitin sulfate proteoglycans

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3418570

29 September 2017

The antiepidermal growth factor receptor monoclonal antibody cetuximab/C225 reduces hypoxia-inducible factor-1 alpha, leading to transcriptional inhibition of vascular endothelial growth factor expression

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3418570

29 September 2017

Inflammation and apoptosis: linked therapeutic targets in spinal cord injury

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3418570

29 September 2017

Importance of MAPK pathways for microglial pro-inflammatory cytokine IL-1 beta production

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3418570

29 September 2017

Minocycline treatment reduces delayed oligodendrocyte death, attenuates axonal dieback, and improves functional outcome after spinal cord injury.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3418570

29 September 2017

Cytokines: powerful regulators of glial cell activation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3418570

29 September 2017

Role of p38 and p44/42 mitogen-activated protein kinases in microglia

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3418570

29 September 2017

Transforming growth factor-alpha (TGF-alpha) and epidermal growth factor-receptor (EGF-R) immunoreactivity in normal and pathologic brain.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3418570

29 September 2017

Mechanisms of secondary injury to spinal cord axons in vitro: role of Na+, Na(+)-K(+)-ATPase, the Na(+)-H+ exchanger, and the Na(+)-Ca2+ exchanger.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3418570

29 September 2017

Functional plasticity of microglia: a review

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3418570

29 September 2017

Activation of p-38alpha MAPK contributes to neuronal hyperexcitability in caudal regions remote from spinal cord injury

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3418570

3 June 2018

The Rheb-mTOR pathway is upregulated in reactive astrocytes of the injured spinal cord.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3418570

3 June 2018

ERK1/2 and p38 mitogen-activated protein kinase mediate iNOS-induced spinal neuron degeneration after acute traumatic spinal cord injury

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3418570

3 June 2018

Angiotensin II triggers EGFR tyrosine kinase-dependent Ca2+ influx in afferent arterioles

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3418570

3 June 2018

Depletion of hematogenous macrophages promotes partial hindlimb recovery and neuroanatomical repair after experimental spinal cord injury

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3418570

3 June 2018

Epidermal growth factor receptor immunoreactivity in rat brain. Development and cellular localization

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3418570

3 June 2018

Epidermal growth factor receptor immunoreactivity in rat brain astrocytes. Response to injury

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3418570

3 June 2018

Immunoreactive epidermal growth factor receptors in neuritic plaques from patients with Alzheimer's disease.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3418570

3 June 2018

An immortalized cell line expresses properties of activated microglial cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3418570

3 June 2018

Cell cycle inhibition attenuates microglia induced inflammatory response and alleviates neuronal cell death after spinal cord injury in rats.

1 reference

https://api.crossref.org/works/10.1186%2F1742-2094-9-178

21 January 2018

Activation of epidermal growth factor receptor causes astrocytes to form cribriform structures.

1 reference

https://api.crossref.org/works/10.1186%2F1742-2094-9-178

21 January 2018

Epidermal growth factor is a motility factor for microglial cells in vitro: evidence for EGF receptor expression.

1 reference

https://api.crossref.org/works/10.1186%2F1742-2094-9-178

21 January 2018

Epidermal growth factor receptor in proliferating reactive glia following transient focal ischemia in the rat brain.

1 reference

https://api.crossref.org/works/10.1186%2F1742-2094-9-178

21 January 2018

Early profiles of axonal growth and astroglial response after spinal cord hemisection and implantation of Schwann cell-seeded guidance channels in adult rats.

1 reference

https://api.crossref.org/works/10.1186%2F1742-2094-9-178

21 January 2018

The influence of p38 mitogen-activated protein kinase inhibitor on synthesis of inflammatory cytokine tumor necrosis factor alpha in spinal cord of rats with chronic constriction injury.

1 reference

https://api.crossref.org/works/10.1186%2F1742-2094-9-178

21 January 2018

Activated microglia initiate motor neuron injury by a nitric oxide and glutamate-mediated mechanism

1 reference

https://api.crossref.org/works/10.1186%2F1742-2094-9-178

21 January 2018

Regulation of interleukin-1beta by the interleukin-1 receptor antagonist in the glutamate-injured spinal cord: endogenous neuroprotection

1 reference

https://api.crossref.org/works/10.1186%2F1742-2094-9-178

21 January 2018

Effects of Etanercept and Minocycline in a rat model of spinal cord injury

1 reference

https://api.crossref.org/works/10.1186%2F1742-2094-9-178

21 January 2018

Immunomodulatory effects of etanercept in an experimental model of spinal cord injury

1 reference

https://api.crossref.org/works/10.1186%2F1742-2094-9-178

21 January 2018

Tumor necrosis factor-α antagonist reduces apoptosis of neurons and oligodendroglia in rat spinal cord injury

1 reference

https://api.crossref.org/works/10.1186%2F1742-2094-9-178

21 January 2018

Evidence for the role of mitogen-activated protein kinase signaling pathways in the development of spinal cord injury

1 reference

https://api.crossref.org/works/10.1186%2F1742-2094-9-178

21 January 2018

Continuous intrathecal infusion of SB203580, a selective inhibitor of p38 mitogen-activated protein kinase, reduces the damage of hind-limb function after thoracic spinal cord injury in rat

1 reference

https://api.crossref.org/works/10.1186%2F1742-2094-9-178

21 January 2018

JNK inhibition and inflammation after cerebral ischemia

1 reference

https://api.crossref.org/works/10.1186%2F1742-2094-9-178

21 January 2018

Enhanced expression of cyclooxygenase-2 and prostaglandin E2 in response to endotoxin after trauma is dependent on MAPK and NF-kappaB mechanisms

1 reference

https://api.crossref.org/works/10.1186%2F1742-2094-9-178

21 January 2018

The effect of activated microglia on astrogliosis parameters in astrocyte cultures.

1 reference

https://api.crossref.org/works/10.1186%2F1742-2094-9-178

21 January 2018

TNF alpha and IL-1beta mediate intercellular adhesion molecule-1 induction via microglia-astrocyte interaction in CNS radiation injury.

1 reference

https://api.crossref.org/works/10.1186%2F1742-2094-9-178

21 January 2018

Epidermal growth factor receptor inhibitors promote CNS axon growth through off-target effects on glia.

1 reference

https://api.crossref.org/works/10.1186%2F1742-2094-9-178

21 January 2018

alpha(2)-Adrenergic receptors activate MAPK and Akt through a pathway involving arachidonic acid metabolism by cytochrome P450-dependent epoxygenase, matrix metalloproteinase activation and subtype-specific transactivation of EGFR.

1 reference

https://api.crossref.org/works/10.1186%2F1742-2094-9-178

21 January 2018

Effects of microglia-derived cytokines on astrocyte proliferation.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3418570

27 November 2018

Dissecting the epidermal growth factor receptor signal transactivation pathway.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3418570

27 November 2018

Cellular and molecular mechanisms of glial scarring and progressive cavitation: in vivo and in vitro analysis of inflammation-induced secondary injury after CNS trauma.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3418570

27 November 2018

Hypothalamic lesions that induce female precocious puberty activate glial expression of the epidermal growth factor receptor gene: differential regulation of alternatively spliced transcripts.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3418570

27 November 2018

Behavioral assessment of functional deficit in rats with contusive spinal cord injury

1 reference

https://pubmed.ncbi.nlm.nih.gov/22824323

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Inhibiting epidermal growth factor receptor attenuates reactive astrogliosis and improves functional outcome after spinal cord injury in rats

1 reference

https://pubmed.ncbi.nlm.nih.gov/22824323

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Severity-dependent expression of pro-inflammatory cytokines in traumatic spinal cord injury in the rat

1 reference

https://pubmed.ncbi.nlm.nih.gov/22824323

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Delayed neuronal damage related to microglia proliferation after mild spinal cord compression injury

1 reference

https://pubmed.ncbi.nlm.nih.gov/22824323

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Beneficial effect of interleukin-1 receptor antagonist protein on spinal cord injury recovery in the rat

1 reference

https://pubmed.ncbi.nlm.nih.gov/22824323

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Growth hormone-induced tyrosine phosphorylation of EGF receptor as an essential element leading to MAP kinase activation and gene expression

1 reference

https://pubmed.ncbi.nlm.nih.gov/22824323

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

[Pathophysiology of acute spinal cord injury]

1 reference

https://pubmed.ncbi.nlm.nih.gov/22824323

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Optimized protocols for isolation of primary motor neurons, astrocytes and microglia from embryonic mouse spinal cord.

1 reference

https://pubmed.ncbi.nlm.nih.gov/22824323

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Vascular permeability in experimental spinal cord injury

1 reference

https://pubmed.ncbi.nlm.nih.gov/22824323

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effect of bacterial wall lipopolysaccharide (LPS) on morphology, motility, and cytoskeletal organization of microglia in cultures

1 reference

https://pubmed.ncbi.nlm.nih.gov/22824323

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The dual role of tumor necrosis factor-alpha in the pathophysiology of spinal cord injury

1 reference

https://pubmed.ncbi.nlm.nih.gov/22824323

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1186/1742-2094-9-178

1 reference

Consolidated OpenCitations Corpus – April 2017

OpenCitations bibliographic resource ID

Dimensions Publication ID

1 reference

9 September 2019

https://scigraph.springernature.com/pub.10.1186/1742-2094-9-178

OpenCitations bibliographic resource ID

1 reference

Consolidated OpenCitations Corpus – April 2017

OpenCitations bibliographic resource ID

1 reference

Consolidated OpenCitations Corpus – April 2017

OpenCitations bibliographic resource ID

1 reference

Consolidated OpenCitations Corpus – April 2017

OpenCitations bibliographic resource ID

ResearchGate publication ID

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