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PAK is regulated by PI3K, PIX, CDC42, and PP2Calpha and mediates focal adhesion turnover in the hyperosmotic stress-induced p38 pathway
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PubMed
PubMed ID
18586681
retrieved
31 January 2017
title
PAK is regulated by PI3K, PIX, CDC42, and PP2Calpha and mediates focal adhesion turnover in the hyperosmotic stress-induced p38 pathway
(English)
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PubMed
PubMed ID
18586681
retrieved
31 January 2017
author name string
Perry M. Chan
series ordinal
1
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PubMed
PubMed ID
18586681
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31 January 2017
Louis Lim
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2
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PubMed
PubMed ID
18586681
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31 January 2017
Edward Manser
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3
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PubMed
PubMed ID
18586681
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31 January 2017
language of work or name
English
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publication date
5 September 2008
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PubMed
PubMed ID
18586681
retrieved
31 January 2017
published in
Journal of Biological Chemistry
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PubMed
PubMed ID
18586681
retrieved
31 January 2017
volume
283
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PubMed
PubMed ID
18586681
retrieved
31 January 2017
issue
36
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PubMed
PubMed ID
18586681
retrieved
31 January 2017
page(s)
24949–24961
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PubMed
PubMed ID
18586681
retrieved
31 January 2017
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Europe PubMed Central
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11 June 2022
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https://www.ebi.ac.uk/europepmc/webservices/rest/PMC3259815/fullTextXML
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Adhesion stimulates direct PAK1/ERK2 association and leads to ERK-dependent PAK1 Thr212 phosphorylation
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Merlin, the Product of the Nf2 Tumor Suppressor Gene, Is an Inhibitor of the p21-Activated Kinase, Pak1
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Dexamethasone causes sustained expression of mitogen-activated protein kinase (MAPK) phosphatase 1 and phosphatase-mediated inhibition of MAPK p38.
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P21-activated kinase-1 phosphorylates and transactivates estrogen receptor-alpha and promotes hyperplasia in mammary epithelium
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Rac-PAK signaling stimulates extracellular signal-regulated kinase (ERK) activation by regulating formation of MEK1-ERK complexes
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The p21-activated kinase PAK is negatively regulated by POPX1 and POPX2, a pair of serine/threonine phosphatases of the PP2C family
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Regulation of the p21-activated kinase (PAK) by a human Gbeta -like WD-repeat protein, hPIP1
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Ptc1, a type 2C Ser/Thr phosphatase, inactivates the HOG pathway by dephosphorylating the mitogen-activated protein kinase Hog1
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Structure of PAK1 in an autoinhibited conformation reveals a multistage activation switch
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Yeast Cdc42 GTPase and Ste20 PAK-like kinase regulate Sho1-dependent activation of the Hog1 MAPK pathway.
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p21-activated kinase 1 phosphorylates the death agonist bad and protects cells from apoptosis
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alphaPIX nucleotide exchange factor is activated by interaction with phosphatidylinositol 3-kinase
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17 March 2017
PAK2 is cleaved and activated during hyperosmotic shock-induced apoptosis via a caspase-dependent mechanism: evidence for the involvement of oxidative stress
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17 March 2017
The protein kinase Pak3 positively regulates Raf-1 activity through phosphorylation of serine 338
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Protein phosphatase 2Calpha inhibits the human stress-responsive p38 and JNK MAPK pathways
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17 March 2017
PAK kinases are directly coupled to the PIX family of nucleotide exchange factors
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Expression of constitutively active alpha-PAK reveals effects of the kinase on actin and focal complexes
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29 September 2017
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29 September 2017
Activation of Syk protein tyrosine kinase in response to osmotic stress requires interaction with p21-activated protein kinase Pak2/gamma-PAK.
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Rac-MEKK3-MKK3 scaffolding for p38 MAPK activation during hyperosmotic shock.
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p21-activated protein kinase gamma-PAK is translocated and activated in response to hyperosmolarity. Implication of Cdc42 and phosphoinositide 3-kinase in a two-step mechanism for gamma-PAK activation
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29 September 2017
MP2C, a plant protein phosphatase 2C, functions as a negative regulator of mitogen-activated protein kinase pathways in yeast and plants
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Activation of p21-activated protein kinase alpha (alpha PAK) by hyperosmotic shock in neonatal ventricular myocytes
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PAK2 is cleaved and activated during hyperosmotic shock-induced apoptosis via a caspase-dependent mechanism: Evidence for the involvement of oxidative stress
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Oncogenic K-RAS is required to maintain changes in cytoskeletal organization, adhesion, and motility in colon cancer cells.
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Phosphatidylinositol 3-kinase regulates Raf1 through Pak phosphorylation of serine 338
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12 December 2020
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inferred from PubMed ID database lookup
Identifiers
DOI
10.1074/JBC.M801728200
1 reference
stated in
Consolidated OpenCitations Corpus – April 2017
OpenCitations bibliographic resource ID
2049271
OpenCitations bibliographic resource ID
2049271
1 reference
stated in
Consolidated OpenCitations Corpus – April 2017
OpenCitations bibliographic resource ID
2049271
PMCID
3259815
1 reference
stated in
Consolidated OpenCitations Corpus – April 2017
OpenCitations bibliographic resource ID
2049271
PubMed ID
18586681
1 reference
stated in
Consolidated OpenCitations Corpus – April 2017
OpenCitations bibliographic resource ID
2049271
ResearchGate publication ID
5268663
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