(Q28593254)

24 June 2017

Rescue of fragile X syndrome phenotypes in Fmr1 KO mice by the small-molecule PAK inhibitor FRAX486. (English)

1 reference

P21 (RAC1) activated kinase 4

24 June 2017

1 reference

P21 (RAC1) activated kinase 2

1 reference

Synaptic functional regulator FMR1

1 reference

Serine/threonine-protein kinase PAK 1

1 reference

P21 (RAC1) activated kinase 3

1 reference

1 reference

10

Susumu Tonegawa

1 reference

24 June 2017

Se-Young Choi

9

0 references

Arvind Govindarajan

8

object named as

Arvind Govindarajan

1 reference

24 June 2017

Benedikt Vollrath

4

1 reference

24 June 2017

Hui-Yeon Ko

6

1 reference

24 June 2017

Bridget M Dolan

1

1 reference

24 June 2017

Sergio G Duron

2

1 reference

24 June 2017

David A Campbell

3

1 reference

24 June 2017

B S Shankaranarayana Rao

5

1 reference

24 June 2017

Gregory G Lin

7

1 reference

24 June 2017

language of work or name

English

0 references

publication date

18 March 2013

1 reference

Proceedings of the National Academy of Sciences of the United States of America

24 June 2017

1 reference

24 June 2017

110

1 reference

24 June 2017

5671-5676

1 reference

24 June 2017

14

1 reference

The pathophysiology of fragile X (and what it teaches us about synapses)

24 June 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3619302

Modifying behavioral phenotypes in Fmr1KO mice: genetic background differences reveal autistic-like responses

17 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3619302

p21-Activated kinases 1 and 3 control brain size through coordinating neuronal complexity and synaptic properties

17 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3619302

Advances in the treatment of fragile X syndrome

17 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3619302

Psychiatric disorders in children with autism spectrum disorders: prevalence, comorbidity, and associated factors in a population-derived sample

17 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3619302

An isoform-selective, small-molecule inhibitor targets the autoregulatory mechanism of p21-activated kinase

17 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3619302

Advances in autism genetics: on the threshold of a new neurobiology

17 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3619302

Correction of fragile X syndrome in mice.

17 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3619302

Inhibition of p21-activated kinase rescues symptoms of fragile X syndrome in mice

17 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3619302

The blood-brain barrier: bottleneck in brain drug development

17 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3619302

The mental retardation protein PAK3 contributes to synapse formation and plasticity in hippocampus

17 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3619302

PAK3 mutation in nonsyndromic X-linked mental retardation

17 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3619302

Abnormal dendritic spines in fragile X knockout mice: maturation and pruning deficits

17 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3619302

A brain serine/threonine protein kinase activated by Cdc42 and Rac1

17 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3619302

Identification of a gene (FMR-1) containing a CGG repeat coincident with a breakpoint cluster region exhibiting length variation in fragile X syndrome

17 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3619302

Molecular mechanisms of dendritic spine morphogenesis

17 March 2017

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1219383110

A systematic review of medical treatments for children with autism spectrum disorders

22 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3619302

Glutamate N-methyl-D-aspartate receptor antagonists rapidly reverse behavioral and synaptic deficits caused by chronic stress exposure

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3619302

Physiological activation of synaptic Rac>PAK (p-21 activated kinase) signaling is defective in a mouse model of fragile X syndrome

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3619302

Local protein synthesis, actin dynamics, and LTP consolidation

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3619302

Animal models of restricted repetitive behavior in autism

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3619302

FMRP interferes with the Rac1 pathway and controls actin cytoskeleton dynamics in murine fibroblasts.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3619302

Hippocampal LTP is accompanied by enhanced F-actin content within the dendritic spine that is essential for late LTP maintenance in vivo

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3619302

Abnormal dendritic spine characteristics in the temporal and visual cortices of patients with fragile-X syndrome: a quantitative examination.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3619302

Cognitive and behavioral profile of fragile X boys: correlations to molecular data

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3619302

Chronic pharmacological mGlu5 inhibition corrects fragile X in adult mice.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3619302

Regulation of hippocampal long-term potentiation by p21-activated protein kinase 1 (PAK1).

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3619302

Altered cortical synaptic morphology and impaired memory consolidation in forebrain- specific dominant-negative PAK transgenic mice

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3619302

Adult fragile X syndrome. Clinico-neuropathologic findings.

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3619302

Analysis of neocortex in three males with the fragile X syndrome

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3619302

Trends in the prevalence of developmental disabilities in US children, 1997-2008.

3 June 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1219383110

The Drosophila easily shocked gene: a mutation in a phospholipid synthetic pathway causes seizure, neuronal failure, and paralysis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1219383110

Fragile X mice develop sensory hyperreactivity to auditory stimuli

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1219383110

A phenotypic and molecular characterization of the fmr1-tm1Cgr fragile X mouse.

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1219383110

Suppression of two major Fragile X Syndrome mouse model phenotypes by the mGluR5 antagonist MPEP.

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1219383110

Dendritic spine and dendritic field characteristics of layer V pyramidal neurons in the visual cortex of fragile-X knockout mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1219383110

Role of p21-activated kinase pathway defects in the cognitive deficits of Alzheimer disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1219383110

CYFIP/Sra-1 controls neuronal connectivity in Drosophila and links the Rac1 GTPase pathway to the fragile X protein.

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1219383110

Epilepsy in fragile X syndrome.

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1219383110

Autism and epilepsy: a retrospective follow-up study.

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1219383110

A null mutation for Fmr1 in female mice: effects on regional cerebral metabolic rate for glucose and relationship to behavior

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1219383110

Increased dendritic spine densities on cortical projection neurons in autism spectrum disorders

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1219383110

Epilepsy and EEG findings in males with fragile X syndrome.

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1219383110

Audiogenic seizure susceptibility is reduced in fragile X knockout mice after introduction of FMR1 transgenes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1219383110

Opposite effects of fear conditioning and extinction on dendritic spine remodelling.

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1219383110

FVB.129P2-Pde6b(+) Tyr(c-ch)/Ant, a sighted variant of the FVB/N mouse strain suitable for behavioral analysis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1219383110

Chronic stress induces contrasting patterns of dendritic remodeling in hippocampal and amygdaloid neurons.

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3619302

The fragile X syndrome. A study of 83 families.

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3619302

Fmr1 knockout mice: a model to study fragile X mental retardation. The Dutch-Belgian Fragile X Consortium

27 November 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/23509247

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1073/PNAS.1219383110

1 reference

release_73qw2jcn6vgxloffnplmno4l4y

24 June 2017

0 references

1 reference

Fatcat

https://api.fatcat.wiki/v0/release/73qw2jcn6vgxloffnplmno4l4y

mapped directly with Wikidata item

24 November 2022

based on heuristic

OpenCitations bibliographic resource ID

796149

1 reference

Consolidated OpenCitations Corpus – April 2017

OpenCitations bibliographic resource ID

1 reference

Consolidated OpenCitations Corpus – April 2017

OpenCitations bibliographic resource ID

1 reference