(Q28593632)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19906996%20AND%20SRC:MED&resulttype=core&format=json

12 February 2020

title

Ras is an indispensable coregulator of the class IB phosphoinositide 3-kinase p87/p110gamma (English)

2 references

31 January 2017

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19906996%20AND%20SRC:MED&resulttype=core&format=json

Phosphoinositide-3-kinase regulatory subunit 5

12 February 2020

main subject

1 reference

GOA release 2020-03-11

author

Matthias P Wymann

10

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19906996%20AND%20SRC:MED&resulttype=core&format=json

12 February 2020

Bernd Nürnberg

12

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19906996%20AND%20SRC:MED&resulttype=core&format=json

12 February 2020

author name string

Barbara Kurig

1

2 references

31 January 2017

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19906996%20AND%20SRC:MED&resulttype=core&format=json

12 February 2020

Aliaksei Shymanets

2

2 references

31 January 2017

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19906996%20AND%20SRC:MED&resulttype=core&format=json

12 February 2020

Thomas Bohnacker

3

2 references

31 January 2017

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19906996%20AND%20SRC:MED&resulttype=core&format=json

12 February 2020

Carsten Brock

5

2 references

31 January 2017

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19906996%20AND%20SRC:MED&resulttype=core&format=json

12 February 2020

Michael Schaefer

7

2 references

31 January 2017

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19906996%20AND%20SRC:MED&resulttype=core&format=json

12 February 2020

Antje Gohla

8

2 references

31 January 2017

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19906996%20AND%20SRC:MED&resulttype=core&format=json

12 February 2020

Christian Harteneck

9

2 references

31 January 2017

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19906996%20AND%20SRC:MED&resulttype=core&format=json

12 February 2020

Elisabeth Jeanclos

11

2 references

31 January 2017

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19906996%20AND%20SRC:MED&resulttype=core&format=json

12 February 2020

Prajwal

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19906996%20AND%20SRC:MED&resulttype=core&format=json

12 February 2020

Mohammad Reza Ahmadian

6

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19906996%20AND%20SRC:MED&resulttype=core&format=json

12 February 2020

language of work or name

English

0 references

publication date

11 November 2009

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19906996%20AND%20SRC:MED&resulttype=core&format=json

Proceedings of the National Academy of Sciences of the United States of America

12 February 2020

published in

2 references

31 January 2017

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19906996%20AND%20SRC:MED&resulttype=core&format=json

12 February 2020

volume

106

2 references

31 January 2017

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19906996%20AND%20SRC:MED&resulttype=core&format=json

12 February 2020

issue

48

2 references

31 January 2017

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19906996%20AND%20SRC:MED&resulttype=core&format=json

12 February 2020

page(s)

20312-20317

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19906996%20AND%20SRC:MED&resulttype=core&format=json

Targeting phosphoinositide 3-kinase: moving towards therapy

12 February 2020

cites work

1 reference

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PI3K delta and PI3K gamma: partners in crime in inflammation in rheumatoid arthritis and beyond?

17 March 2017

1 reference

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PI3Kgamma inhibition: towards an 'aspirin of the 21st century'?

17 March 2017

1 reference

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p84, a new Gbetagamma-activated regulatory subunit of the type IB phosphoinositide 3-kinase p110gamma

17 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2787109

Roles of G beta gamma in membrane recruitment and activation of p110 gamma/p101 phosphoinositide 3-kinase gamma

17 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2787109

Crystal structure and functional analysis of Ras binding to its effector phosphoinositide 3-kinase gamma

17 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2787109

Regulation of a novel human phospholipase C, PLCepsilon, through membrane targeting by Ras

17 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2787109

The G beta gamma sensitivity of a PI3K is dependent upon a tightly associated adaptor, p101

17 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2787109

Cloning and characterization of a G protein-activated human phosphoinositide-3 kinase

17 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2787109

Activation of Raf as a result of recruitment to the plasma membrane

17 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2787109

Fine tuning the immune response with PI3K.

7 April 2017

1 reference

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Pasteurella multocida toxin activates Gbetagamma dimers of heterotrimeric G proteins

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2787109

Class I PI3K in oncogenic cellular transformation.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2787109

Phosphoinositide 3-kinase p110beta activity: key role in metabolism and mammary gland cancer but not development

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2787109

Essential roles of PI(3)K-p110beta in cell growth, metabolism and tumorigenesis

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2787109

The p110beta isoform of phosphoinositide 3-kinase signals downstream of G protein-coupled receptors and is functionally redundant with p110gamma.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2787109

Phosphoinositide 3-kinases as a common platform for multi-hormone signaling.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2787109

Deletion of the phosphoinositide 3-kinase p110gamma gene attenuates murine atherosclerosis

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2787109

Antigen receptor signalling: a distinctive role for the p110delta isoform of PI3K.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2787109

Signalling through Class I PI3Ks in mammalian cells

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2787109

Characterization of p87PIKAP, a novel regulatory subunit of phosphoinositide 3-kinase gamma that is highly expressed in heart and interacts with PDE3B.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2787109

Assigning functional domains within the p101 regulatory subunit of phosphoinositide 3-kinase gamma

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2787109

Signaling specificity by Ras family GTPases is determined by the full spectrum of effectors they regulate

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2787109

Phosphoinositide 3-kinase gamma: a key modulator in inflammation and allergy

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2787109

Identification and characterization of the autophosphorylation sites of phosphoinositide 3-kinase isoforms beta and gamma

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2787109

Activation of phosphoinositide 3-kinase gamma by Ras.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2787109

Regulating c-Ras function. cholesterol depletion affects caveolin association, GTP loading, and signaling

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2787109

Central role for G protein-coupled phosphoinositide 3-kinase gamma in inflammation.

29 September 2017

1 reference

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Function of PI3Kgamma in thymocyte development, T cell activation, and neutrophil migration

29 September 2017

1 reference

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Cholesterol depletion of caveolae causes hyperactivation of extracellular signal-related kinase (ERK).

29 September 2017

1 reference

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Gbetagamma-copurified lipid kinase impurity from Sf9 cells

29 September 2017

1 reference

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Angiogenesis selectively requires the p110alpha isoform of PI3K to control endothelial cell migration.

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2787109

Purification and characterization of Gbetagamma-responsive phosphoinositide 3-kinases from pig platelet cytosol

3 June 2018

1 reference

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PI3Kγ Modulates the Cardiac Response to Chronic Pressure Overload by Distinct Kinase-Dependent and -Independent Effects

3 June 2018

1 reference

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Resistance to thromboembolism in PI3Kgamma-deficient mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0905506106

Phosphoinositide 3-kinase isoforms selectively couple receptors to vascular L-type Ca(2+) channels

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0905506106

Gbeta 5gamma 2 is a highly selective activator of phospholipid-dependent enzymes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0905506106

PI3Kgamma is a key regulator of inflammatory responses and cardiovascular homeostasis

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0905506106

PI3Kgamma adaptor subunits define coupling to degranulation and cell motility by distinct PtdIns(3,4,5)P3 pools in mast cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0905506106

Gbetagammas and the Ras binding domain of p110gamma are both important regulators of PI(3)Kgamma signalling in neutrophils

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0905506106

Signaling through PI3Kgamma: a common platform for leukocyte, platelet and cardiovascular stress sensing.

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2787109

Blockade of PI3Kgamma suppresses joint inflammation and damage in mouse models of rheumatoid arthritis.

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2787109

PI3Kgamma inhibition blocks glomerulonephritis and extends lifespan in a mouse model of systemic lupus

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2787109

Phosphoinositide 3-kinase gamma is an essential amplifier of mast cell function

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2787109

Individual Rate Constants for the Interaction of Ras Proteins with GTPase-Activating Proteins Determined by Fluorescence Spectroscopy

27 November 2018

1 reference

12 December 2020

Heterodimeric phosphoinositide 3-kinase consisting of p85 and p110beta is synergistically activated by the betagamma subunits of G proteins and phosphotyrosyl peptide

1 reference

12 December 2020

Roles of non-catalytic subunits in gbetagamma-induced activation of class I phosphoinositide 3-kinase isoforms beta and gamma

1 reference

12 December 2020

Finding Partners for PI3K : When 84 Is Better Than 101

1 reference

12 December 2020

Identifiers

DOI

10.1073/PNAS.0905506106

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19906996%20AND%20SRC:MED&resulttype=core&format=json

12 February 2020

ADS bibcode

2009PNAS..10620312K

0 references

1 reference

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19906996%20AND%20SRC:MED&resulttype=core&format=json

12 February 2020

2 references