(Q28731390)

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Delayed mTOR inhibition with low dose of everolimus reduces TGFβ expression, attenuates proteinuria and renal damage in the renal mass reduction model

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Delayed mTOR inhibition with low dose of everolimus reduces TGFβ expression, attenuates proteinuria and renal damage in the renal mass reduction model (English)

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Pepita Giménez-Bonafé

object named as

Pepita Gimenez-Bonafe

4

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object named as

Oscar Noboa

14

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object named as

José Boggia

7

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José M López-Novoa

object named as

José M López-Novoa

12

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author name string

Melania Kurdián

1

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Inmaculada Herrero-Fresneda

2

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Nuria Lloberas

3

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Virginia Coria

5

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María T Grande

6

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Leonel Malacrida

8

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Joan Torras

9

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Miguel A Arévalo

10

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Francisco González-Martínez

11

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Josep Grinyó

13

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language of work or name

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publication date

2012

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7

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3

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e32516

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copyright license

Creative Commons Attribution 4.0 International

12 March 2012

1 reference

April 2022 Public Data File from Crossref

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0 references

Noncanonical TGF-beta pathways, mTORC1 and Abl, in renal interstitial fibrogenesis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3299670

17 March 2017

Prolonged rapamycin treatment inhibits mTORC2 assembly and Akt/PKB

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3299670

17 March 2017

Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3299670

17 March 2017

Upstream and downstream of mTOR

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3299670

17 March 2017

Deletion of H-Ras decreases renal fibrosis and myofibroblast activation following ureteral obstruction in mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3299670

3 June 2018

The role of the mammalian target of rapamycin (mTOR) in renal disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3299670

3 June 2018

The pathogenesis and treatment of chronic allograft nephropathy

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3299670

3 June 2018

Fibroblast activation and myofibroblast generation in obstructive nephropathy

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3299670

3 June 2018

Distinct roles for mammalian target of rapamycin complexes in the fibroblast response to transforming growth factor-beta

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3299670

3 June 2018

mTOR regulates expression of slit diaphragm proteins and cytoskeleton structure in podocytes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3299670

3 June 2018

mToR inhibitors-induced proteinuria: mechanisms, significance, and management

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3299670

3 June 2018

The mTOR inhibitor everolimus induces proteinuria and renal deterioration in the remnant kidney model in the rat.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3299670

3 June 2018

Can mTOR inhibitors reduce the risk of late kidney allograft failure?

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3299670

3 June 2018

Renal fibrosis and the origin of the renal fibroblast

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3299670

3 June 2018

Everolimus: a review of its use in renal and cardiac transplantation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3299670

3 June 2018

Progression in chronic kidney disease.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3299670

3 June 2018

TGF-beta signaling in renal disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3299670

3 June 2018

In vivo bradykinin B2 receptor activation reduces renal fibrosis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3299670

3 June 2018

Mechanisms underlying renoprotection during renin-angiotensin system blockade.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3299670

3 June 2018

Tubular epithelial-myofibroblast transdifferentiation in progressive tubulointerstitial fibrosis in 5/6 nephrectomized rats.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3299670

3 June 2018

Interaction of angiotensin II and TGF-beta 1 in the rat remnant kidney

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3299670

3 June 2018

Tubulointerstitial changes as a major determinant in the progression of renal damage

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3299670

3 June 2018

The natural history of chronic allograft nephropathy

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0032516

21 January 2018

Calcium citrate ameliorates the progression of chronic renal injury.

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0032516

21 January 2018

Mammalian target of rapamycin inhibition prevents glomerular hypertrophy in a model of renal mass reduction.

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0032516

21 January 2018

Long-term rapamycin therapy in the Han:SPRD rat model of polycystic kidney disease (PKD).

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0032516

21 January 2018

Sirolimus increases transforming growth factor-beta1 expression and potentiates chronic cyclosporine nephrotoxicity

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0032516

21 January 2018

Sirolimus Prolongs Recovery from Delayed Graft Function After Cadaveric Renal Transplantation

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0032516

21 January 2018

mTOR inhibitor everolimus ameliorates progressive tubular dysfunction in chronic renal failure rats.

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0032516

21 January 2018

Rapamycin ameliorates proteinuria-associated tubulointerstitial inflammation and fibrosis in experimental membranous nephropathy.

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0032516

21 January 2018

Rapamycin markedly slows disease progression in a rat model of polycystic kidney disease

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0032516

21 January 2018

Low-dose mTOR inhibition by rapamycin attenuates progression in anti-thy1-induced chronic glomerulosclerosis of the rat.

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0032516

21 January 2018

Rapamycin has dual opposing effects on proteinuric experimental nephropathies: is it a matter of podocyte damage?

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3299670

27 November 2018

Thirty year trend in kidney transplants: UCLA and UNOS Renal Transplant Registry

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3299670

27 November 2018

Rapamycin impairs recovery from acute renal failure: role of cell-cycle arrest and apoptosis of tubular cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3299670

27 November 2018

Design and validation of a new image analysis method for automatic quantification of interstitial fibrosis and glomerular morphometry.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3299670

27 November 2018

Proinflammatory effects in experimental mesangial proliferative glomerulonephritis of the immunosuppressive agent SDZ RAD, a rapamycin derivative

1 reference

https://pubmed.ncbi.nlm.nih.gov/22427849

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Role of apoptosis and Bcl-2/Bax in the development of tubulointerstitial fibrosis during experimental obstructive nephropathy

1 reference

https://pubmed.ncbi.nlm.nih.gov/22427849

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Liquid-chromatographic determination of beta 2-microglobulin, alpha 1-acid glycoprotein, and albumin in urine

1 reference

https://pubmed.ncbi.nlm.nih.gov/22427849

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Calcium blockade versus ACE inhibition in clipped and unclipped kidneys of 2K-1C rats

1 reference

https://pubmed.ncbi.nlm.nih.gov/22427849

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Beneficial effect of the long-term treatment with the combination of an ACE inhibitor and a calcium channel blocker on renal injury in rats with 5/6 nephrectomy

1 reference

https://pubmed.ncbi.nlm.nih.gov/22427849

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mammalian Target of Rapamycin Pathway Blockade Slows Progression of Diabetic Kidney Disease in Rats

1 reference

https://pubmed.ncbi.nlm.nih.gov/22427849

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Rapamycin attenuates unilateral ureteral obstruction-induced renal fibrosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/22427849

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Conversion from a calcineurin inhibitor-based immunosuppressive regimen to everolimus in renal transplant recipients: effect on renal function and proteinuria

1 reference

https://pubmed.ncbi.nlm.nih.gov/22427849

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Influence of sirolimus on proteinuria in de novo kidney transplantation with expanded criteria donors: comparison of two CNI-free protocols

1 reference

https://pubmed.ncbi.nlm.nih.gov/22427849

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Renoprotective effects of sirolimus in non-immune initiated focal segmental glomerulosclerosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/22427849

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

High sirolimus levels may induce focal segmental glomerulosclerosis de novo

1 reference

https://pubmed.ncbi.nlm.nih.gov/22427849

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mammalian Target of Rapamycin Inhibition Halts the Progression of Proteinuria in a Rat Model of Reduced Renal Mass

1 reference

https://pubmed.ncbi.nlm.nih.gov/22427849

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The mTOR inhibitor everolimus attenuates the time course of chronic anti-Thy1 nephritis in the rat

1 reference

https://pubmed.ncbi.nlm.nih.gov/22427849

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cold ischemia in the absence of alloreactivity induces chronic transplant nephropathy through a process mediated by the platelet-activating factor

1 reference

https://pubmed.ncbi.nlm.nih.gov/22427849

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1371/JOURNAL.PONE.0032516

1 reference

Consolidated OpenCitations Corpus – April 2017

OpenCitations bibliographic resource ID

2012PLoSO...732516K

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OpenCitations bibliographic resource ID

1 reference

Consolidated OpenCitations Corpus – April 2017

OpenCitations bibliographic resource ID

PMC publication ID

1 reference

Consolidated OpenCitations Corpus – April 2017

OpenCitations bibliographic resource ID

PubMed publication ID

1 reference

Consolidated OpenCitations Corpus – April 2017

OpenCitations bibliographic resource ID

ResearchGate publication ID

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