(Q28756853)

English

Evidence for positive selection in the C-terminal domain of the cholesterol metabolism gene PCSK9 based on phylogenetic analysis in 14 primate species

scientific article (publication date: 31 October 2007)

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scholarly article

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17971861%20AND%20SRC:MED&resulttype=core&format=json

9 January 2020

Evidence for positive selection in the C-terminal domain of the cholesterol metabolism gene PCSK9 based on phylogenetic analysis in 14 primate species (English)

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17971861%20AND%20SRC:MED&resulttype=core&format=json

9 January 2020

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9 January 2020

Iftikhar J Kullo

3

object named as

Iftikhar J Kullo

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9 January 2020

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Samantha J McDonough

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9 January 2020

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31 October 2007

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9 January 2020

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9 January 2020

2

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9 January 2020

10

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9 January 2020

e1098

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9 January 2020

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Creative Commons Attribution 4.0 International

31 October 2007

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April 2022 Public Data File from Crossref

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0 references

Catalytic activity is not required for secreted PCSK9 to reduce low density lipoprotein receptors in HepG2 cells

1 reference

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1 reference

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1 reference

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1 reference

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1 reference

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1 reference

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1 reference

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1 reference

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1 reference

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1 reference

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1 reference

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Mutations in PCSK9 cause autosomal dominant hypercholesterolemia

1 reference

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Statistical methods for detecting molecular adaptation

1 reference

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Codon-substitution models for heterogeneous selection pressure at amino acid sites

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1 reference

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When less is more: gene loss as an engine of evolutionary change

1 reference

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1 reference

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HyPhy: hypothesis testing using phylogenies

1 reference

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23 March 2017

Evaluation of an improved branch-site likelihood method for detecting positive selection at the molecular level

1 reference

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Bayes empirical bayes inference of amino acid sites under positive selection

1 reference

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SIFT: Predicting amino acid changes that affect protein function

1 reference

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Human non-synonymous SNPs: server and survey

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SREBPs: activators of the complete program of cholesterol and fatty acid synthesis in the liver

1 reference

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Toward a phylogenetic classification of Primates based on DNA evidence complemented by fossil evidence

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Likelihood ratio tests for detecting positive selection and application to primate lysozyme evolution

1 reference

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7 April 2017

Positive natural selection in the human lineage

1 reference

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7 April 2017

Sequence variations in PCSK9, low LDL, and protection against coronary heart disease

1 reference

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7 April 2017

Comparative analyses of multi-species sequences from targeted genomic regions

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7 April 2017

The Ka/Ks ratio: diagnosing the form of sequence evolution

2 references

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7 April 2017

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0001098

21 January 2018

Codon-substitution models for detecting molecular adaptation at individual sites along specific lineages

1 reference

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7 April 2017

Intra- and interspecific variation in primate gene expression patterns

1 reference

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Likelihood models for detecting positively selected amino acid sites and applications to the HIV-1 envelope gene

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A composite estimate of primate phylogeny

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Severe hypercholesterolemia in four British families with the D374Y mutation in the PCSK9 gene: long-term follow-up and treatment response

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1 reference

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Low LDL cholesterol in individuals of African descent resulting from frequent nonsense mutations in PCSK9.

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1 reference

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based on heuristic

inferred from PubMed ID database lookup

The c.43_44insCTG variation in PCSK9 is associated with low plasma LDL-cholesterol in a Caucasian population

1 reference

https://pubmed.ncbi.nlm.nih.gov/17971861

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

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1 reference

https://pubmed.ncbi.nlm.nih.gov/17971861

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1371/JOURNAL.PONE.0001098

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17971861%20AND%20SRC:MED&resulttype=core&format=json

9 January 2020

2007PLoSO...2.1098D

0 references

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17971861%20AND%20SRC:MED&resulttype=core&format=json

9 January 2020

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17971861%20AND%20SRC:MED&resulttype=core&format=json

9 January 2020

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