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Amyloid-β oligomers are sequestered by both intracellular and extracellular chaperones
scientific journal article
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instance of
scholarly article
1 reference
stated in
PubMed
PubMed ID
23106396
retrieved
14 February 2017
title
Amyloid-β oligomers are sequestered by both intracellular and extracellular chaperones
(English)
1 reference
stated in
PubMed
PubMed ID
23106396
retrieved
14 February 2017
main subject
molecular chaperones
0 references
positive regulation of amyloid fibril formation
1 reference
stated in
Gene Ontology release 2020-05-02
Gene Ontology ID
GO:1905908
regulation of amyloid fibril formation
1 reference
stated in
Gene Ontology release 2020-05-02
Gene Ontology ID
GO:1905906
negative regulation of amyloid fibril formation
2 references
stated in
Gene Ontology release 2020-05-02
Gene Ontology ID
GO:1905907
stated in
GOA release 2020-03-11
Clusterin
1 reference
stated in
GOA release 2020-03-11
Crystallin alpha B
1 reference
stated in
GOA release 2020-03-11
author
David Klenerman
object named as
David Klenerman
series ordinal
6
0 references
John Carver
object named as
John A. Carver
series ordinal
3
0 references
Chris Dobson
series ordinal
5
object named as
Christopher M. Dobson
1 reference
stated in
PubMed
PubMed ID
23106396
retrieved
14 February 2017
Mark R. Wilson
series ordinal
4
object named as
Mark R. Wilson
1 reference
stated in
PubMed
PubMed ID
23106396
retrieved
14 February 2017
Priyanka Narayan
series ordinal
1
object named as
Priyanka Narayan
1 reference
stated in
PubMed
PubMed ID
23106396
retrieved
14 February 2017
Sarah Meehan
series ordinal
2
object named as
Sarah Meehan
1 reference
stated in
PubMed
PubMed ID
23106396
retrieved
14 February 2017
language of work or name
English
0 references
publication date
20 November 2012
1 reference
stated in
PubMed
PubMed ID
23106396
retrieved
14 February 2017
published in
Biochemistry
1 reference
stated in
PubMed
PubMed ID
23106396
retrieved
14 February 2017
volume
51
1 reference
stated in
PubMed
PubMed ID
23106396
retrieved
14 February 2017
page(s)
9270–9276
1 reference
stated in
PubMed
PubMed ID
23106396
retrieved
14 February 2017
issue
46
1 reference
stated in
PubMed
PubMed ID
23106396
retrieved
14 February 2017
cites work
Genome-wide association study identifies variants at CLU and PICALM associated with Alzheimer's disease
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PubMed Central
reference URL
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16 March 2017
The extracellular chaperone clusterin influences amyloid formation and toxicity by interacting with prefibrillar structures
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PubMed Central
reference URL
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16 March 2017
Protein misfolding, functional amyloid, and human disease
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PubMed Central
reference URL
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16 March 2017
stated in
PubMed Central
reference URL
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retrieved
6 April 2017
Protein folding and misfolding
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PubMed Central
reference URL
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16 March 2017
Protein misfolding, evolution and disease
1 reference
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PubMed Central
reference URL
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16 March 2017
The extracellular chaperone clusterin sequesters oligomeric forms of the amyloid-β(1-40) peptide
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4981287
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16 March 2017
Molecular chaperones in protein folding and proteostasis
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4981287
retrieved
7 April 2017
Genome-wide association study identifies variants at CLU and CR1 associated with Alzheimer's disease
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4981287
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7 April 2017
Natural oligomers of the amyloid-beta protein specifically disrupt cognitive function
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PubMed Central
reference URL
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7 April 2017
Inherent toxicity of aggregates implies a common mechanism for protein misfolding diseases
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4981287
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7 April 2017
3D structure of Alzheimer's amyloid-beta(1-42) fibrils
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4981287
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7 April 2017
Molecular mechanisms used by chaperones to reduce the toxicity of aberrant protein oligomers.
1 reference
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PubMed Central
reference URL
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3 June 2018
Direct observation of the interconversion of normal and toxic forms of α-synuclein
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3 June 2018
Conformational differences between two amyloid β oligomers of similar size and dissimilar toxicity
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PubMed Central
reference URL
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3 June 2018
Binding of the molecular chaperone αB-crystallin to Aβ amyloid fibrils inhibits fibril elongation
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4981287
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3 June 2018
Amyloid-β forms fibrils by nucleated conformational conversion of oligomers
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4981287
retrieved
3 June 2018
Intracellular accumulation of amyloid-Beta - a predictor for synaptic dysfunction and neuron loss in Alzheimer's disease
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4981287
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3 June 2018
Mechanism of amyloid plaque formation suggests an intracellular basis of Abeta pathogenicity
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4981287
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3 June 2018
Direct characterization of amyloidogenic oligomers by single-molecule fluorescence
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4981287
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3 June 2018
Structural reorganisation and potential toxicity of oligomeric species formed during the assembly of amyloid fibrils
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4981287
retrieved
3 June 2018
Site-directed mutations in the C-terminal extension of human alphaB-crystallin affect chaperone function and block amyloid fibril formation
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4981287
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3 June 2018
Ageing and vision: structure, stability and function of lens crystallins
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4981287
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3 June 2018
Small heat-shock proteins and clusterin: intra- and extracellular molecular chaperones with a common mechanism of action and function?
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4981287
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3 June 2018
Apolipoprotein J (clusterin) and Alzheimer's disease
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4981287
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3 June 2018
Genealogy of the alpha-crystallin--small heat-shock protein superfamily.
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PubMed Central
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3 June 2018
Alpha B crystallin and HSP28 are enhanced in the cerebral cortex of patients with Alzheimer's disease.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4981287
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3 June 2018
Expression of alpha B-crystallin in Alzheimer's disease.
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4981287
retrieved
3 June 2018
Clusterin facilitates in vivo clearance of extracellular misfolded proteins
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4981287
retrieved
26 November 2018
ANS binding reveals common features of cytotoxic amyloid species
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4981287
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26 November 2018
Plasma and cerebrospinal fluid levels of amyloid beta proteins 1-40 and 1-42 in Alzheimer disease.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4981287
retrieved
26 November 2018
Clusterin (apolipoprotein J) protein levels are increased in hippocampus and in frontal cortex in Alzheimer's disease.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4981287
retrieved
26 November 2018
The extracellular chaperone clusterin potently inhibits human lysozyme amyloid formation by interacting with prefibrillar species
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/23106396
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Aβ40 and Aβ42 Amyloid Fibrils Exhibit Distinct Molecular Recycling Properties
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/23106396
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Small heat shock proteins inhibit in vitro A beta(1-42) amyloidogenesis
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/23106396
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Identifiers
DOI
10.1021/BI301277K
1 reference
stated in
PubMed
PubMed ID
23106396
retrieved
14 February 2017
PMCID
4981287
0 references
PubMed ID
23106396
1 reference
stated in
PubMed
PubMed ID
23106396
retrieved
14 February 2017
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