(Q28830547)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27291296%20AND%20SRC:MED&resulttype=core&format=json

13 March 2020

title

Comparative chemical genomics reveal that the spiroindolone antimalarial KAE609 (Cipargamin) is a P-type ATPase inhibitor (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27291296%20AND%20SRC:MED&resulttype=core&format=json

13 March 2020

0 references

1 reference

2

1 reference

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13 March 2020

Mark Manary

12

1 reference

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13 March 2020

Rebecca Stanhope

15

1 reference

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13 March 2020

Elizabeth Winzeler

21

1 reference

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13 March 2020

author name string

Gregory M Goldgof

1

1 reference

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13 March 2020

Sabine Ottilie

3

1 reference

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13 March 2020

Edgar Vigil

4

1 reference

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13 March 2020

Kenneth E Allen

5

1 reference

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13 March 2020

Felicia Gunawan

6

1 reference

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13 March 2020

Maxim Kostylev

7

1 reference

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13 March 2020

Kiersten A Henderson

8

1 reference

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13 March 2020

Jennifer Yang

9

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27291296%20AND%20SRC:MED&resulttype=core&format=json

13 March 2020

Jake Schenken

10

1 reference

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13 March 2020

Gregory M LaMonte

11

1 reference

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13 March 2020

Ayako Murao

13

1 reference

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13 March 2020

Marie Nachon

14

1 reference

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13 March 2020

Maximo Prescott

16

1 reference

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13 March 2020

Case W McNamara

17

1 reference

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13 March 2020

Carolyn W Slayman

18

1 reference

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13 March 2020

Rommie E Amaro

19

1 reference

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13 March 2020

Yo Suzuki

20

1 reference

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13 March 2020

language of work or name

English

0 references

publication date

13 June 2016

1 reference

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13 March 2020

1 reference

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13 March 2020

volume

6

1 reference

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13 March 2020

page(s)

27806

1 reference

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Creative Commons Attribution 4.0 International

13 March 2020

copyright license

start time

1 June 2016

1 reference

April 2022 Public Data File from Crossref

copyright status

copyrighted

0 references

cites work

The malaria parasite cation ATPase PfATP4 and its role in the mechanism of action of a new arsenal of antimalarial drugs

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Utilizing Chemical Genomics to Identify Cytochrome b as a Novel Drug Target for Chagas Disease

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Pyrazoleamide compounds are potent antimalarials that target Na+ homeostasis in intraerythrocytic Plasmodium falciparum

16 March 2017

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Mutations in the P-Type Cation-Transporter ATPase 4, PfATP4, Mediate Resistance to Both Aminopyrazole and Spiroindolone Antimalarials

16 March 2017

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RNAi screening comes of age: improved techniques and complementary approaches

16 March 2017

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Targeting Plasmodium PI(4)K to eliminate malaria

16 March 2017

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Genome engineering in Saccharomyces cerevisiae using CRISPR-Cas systems

16 March 2017

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Na(+) regulation in the malaria parasite Plasmodium falciparum involves the cation ATPase PfATP4 and is a target of the spiroindolone antimalarials

16 March 2017

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Computational discovery of picomolar Q(o) site inhibitors of cytochrome bc1 complex

16 March 2017

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Spiroindolones, a potent compound class for the treatment of malaria

16 March 2017

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Creation of a bacterial cell controlled by a chemically synthesized genome

16 March 2017

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A multidimensional strategy to detect polypharmacological targets in the absence of structural and sequence homology

16 March 2017

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Enzymatic assembly of DNA molecules up to several hundred kilobases

16 March 2017

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Clustal W and Clustal X version 2.0

16 March 2017

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An antifungal agent inhibits an aminoacyl-tRNA synthetase by trapping tRNA in the editing site

16 March 2017

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16 March 2017

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Target identification in chemical genetics: the (often) missing link

16 March 2017

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Biology, structure and mechanism of P-type ATPases

16 March 2017

1 reference

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Structure, mechanism, and regulation of the Neurospora plasma membrane H+-ATPase

16 March 2017

1 reference

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Visualizing secretion and synaptic transmission with pH-sensitive green fluorescent proteins

16 March 2017

1 reference

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Gapped BLAST and PSI-BLAST: a new generation of protein database search programs

16 March 2017

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High efficiency transformation of intact yeast cells using single stranded nucleic acids as a carrier

16 March 2017

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A system of shuttle vectors and yeast host strains designed for efficient manipulation of DNA in Saccharomyces cerevisiae

16 March 2017

1 reference

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Saccharomyces Genome Database: the genomics resource of budding yeast

16 March 2017

1 reference

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Extra precision glide: docking and scoring incorporating a model of hydrophobic enclosure for protein-ligand complexes

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4904242

OPM: orientations of proteins in membranes database

7 April 2017

1 reference

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A hierarchical approach to all-atom protein loop prediction

7 April 2017

1 reference

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A diarylquinoline drug active on the ATP synthase of Mycobacterium tuberculosis

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4904242

Glide: a new approach for rapid, accurate docking and scoring. 2. Enrichment factors in database screening

7 April 2017

1 reference

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A novel multiple-stage antimalarial agent that inhibits protein synthesis

7 April 2017

1 reference

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Organic Fluorine Hardly Ever Accepts Hydrogen Bonds

9 May 2017

1 reference

The Power of Sophisticated Phenotypic Screening and Modern Mechanism-of-Action Methods

23 May 2017

1 reference

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Cloning Should Be Simple: Escherichia coli DH5α-Mediated Assembly of Multiple DNA Fragments with Short End Homologies

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4904242

Rapid Identification of Chemoresistance Mechanisms Using Yeast DNA Mismatch Repair Mutants

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4904242

Bacterial genome reduction using the progressive clustering of deletions via yeast sexual cycling

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4904242

Structures and characterization of digoxin- and bufalin-bound Na+,K+-ATPase compared with the ouabain-bound complex

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4904242

Pharmacokinetic-pharmacodynamic analysis of spiroindolone analogs and KAE609 in a murine malaria model

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4904242

(+)-SJ733, a clinical candidate for malaria that acts through ATP4 to induce rapid host-mediated clearance of Plasmodium.

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4904242

Confirmation of the cellular targets of benomyl and rapamycin using next-generation sequencing of resistant mutants in S. cerevisiae

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4904242

Diverse chemotypes disrupt ion homeostasis in the Malaria parasite

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4904242

A first-in-human randomized, double-blind, placebo-controlled, single- and multiple-ascending oral dose study of novel antimalarial Spiroindolone KAE609 (Cipargamin) to assess its safety, tolerability, and pharmacokinetics in healthy adult volunteer

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4904242

Spiroindolone KAE609 for falciparum and vivax malaria

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4904242

Identification of pathogen genomic variants through an integrated pipeline

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4904242

Regulation of cation balance in Saccharomyces cerevisiae

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4904242

Alteration of plasma membrane organization by an anticancer lysophosphatidylcholine analogue induces intracellular acidification and internalization of plasma membrane transporters in yeast

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4904242

Drug uptake, lipid rafts, and vesicle trafficking modulate resistance to an anticancer lysophosphatidylcholine analogue in yeast

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4904242

Selective and specific inhibition of the plasmodium falciparum lysyl-tRNA synthetase by the fungal secondary metabolite cladosporin

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4904242

The spiroindolone drug candidate NITD609 potently inhibits gametocytogenesis and blocks Plasmodium falciparum transmission to anopheles mosquito vector

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4904242

Control-FREEC: a tool for assessing copy number and allelic content using next-generation sequencing data

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4904242

Knocking out multigene redundancies via cycles of sexual assortment and fluorescence selection

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4904242

Transcript profiling and RNA interference as tools to identify small molecule mechanisms and therapeutic potential

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4904242

Spirotetrahydro beta-carbolines (spiroindolones): a new class of potent and orally efficacious compounds for the treatment of malaria.

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4904242

CHARMM-GUI Membrane Builder for mixed bilayers and its application to yeast membranes

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4904242

Surface-active fungicidal D-peptide inhibitors of the plasma membrane proton pump that block azole resistance

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4904242

The plasma membrane H(+)-ATPase of fungi. A candidate drug target?

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4904242

Escherichia coli K-12 Mutants Resistant to Nalidixic Acid: Genetic Mapping and Dominance Studies

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4904242

[Sir Joseph Barcroft and the Cambridge physiology school].

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4904242

Yeast plasma membrane ATPase is essential for growth and has homology with (Na+ + K+), K+- and Ca2+-ATPases

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4904242

Pleiotropic plasma membrane ATPase mutations of Saccharomyces cerevisiae

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4904242

Disruption of lipid domain organization in monolayers of complex yeast lipid extracts induced by the lysophosphatidylcholine analogue edelfosine in vivo.

3 June 2018

1 reference

Cytotoxicity of an Anti-cancer Lysophospholipid through Selective Modification of Lipid Raft Composition

21 January 2018

1 reference

Flexible ligand docking with Glide.

21 January 2018

1 reference

Mother-daughter asymmetry of pH underlies aging and rejuvenation in yeast.

21 January 2018

1 reference

In vivo measurement of cytosolic and mitochondrial pH using a pH-sensitive GFP derivative in Saccharomyces cerevisiae reveals a relation between intracellular pH and growth

21 January 2018

1 reference

Protein and ligand preparation: parameters, protocols, and influence on virtual screening enrichments

21 January 2018

1 reference

PROPKA3: Consistent Treatment of Internal and Surface Residues in Empirical pKa Predictions

21 January 2018

2 references

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4904242

21 January 2018

Isolation of transport-competent secretory vesicles from Saccharomyces cerevisiae

26 November 2018

1 reference

12 December 2020

Epik: a software program for pK( a ) prediction and protonation state generation for drug-like molecules

1 reference

12 December 2020

Exploring an antifungal target in the plasma membrane H(+)-ATPase of fungi

1 reference

12 December 2020

Growth control strength and active site of yeast plasma membrane ATPase studied by site-directed mutagenesis

1 reference

12 December 2020

Identifiers

DOI

10.1038/SREP27806

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27291296%20AND%20SRC:MED&resulttype=core&format=json

Dimensions Publication ID

13 March 2020

1040851009

0 references

1 reference

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27291296%20AND%20SRC:MED&resulttype=core&format=json

13 March 2020

2 references