Wikidata

(Q292982)

English

Serpin family A member 1

mammalian protein found in Homo sapiens

  • protease inhibitor 1 (anti-elastase), alpha-1-antitrypsin
  • epididymis secretory sperm binding protein
  • alpha-1 antitrypsin
  • alpha-1 protease inhibitor
  • alpha-1-antiproteinase
  • serine (or cysteine) proteinase inhibitor, clade A, member 1
  • serpin peptidase inhibitor clade A (alpha-1antiproteinase, antitrypsin) member 1
  • serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
  • serpin peptidase inhibitor clade A member 1
  • alpha-1-antitrypsin short transcript variant 1C5
  • alpha-1-antitrypsin null
  • alpha-1-antitrypsin
  • alpha-1-antitrypsin short transcript variant 1C4
  • serpin A1
  • SERPINA1
  • alfa-1-antitrypsin
In more languages

Statements

instance of
medication
1 reference
stated in
DrugBank
DrugBank ID
00058
language of work or name
English
title
Alpha-1-proteinase inhibitor (English)
publication date
17 November 2015
biopharmaceutical
1 reference
stated in
DrugBank
DrugBank ID
00058
language of work or name
English
title
Alpha-1-proteinase inhibitor (English)
publication date
17 November 2015
image
Alpha 1-antitrypsin.png
2,130 × 3,012; 2.25 MB
0 references
molecular function
protein binding
determination method
IPI
11 references
retrieved
8 April 2019
stated in
Role of the lectin VIP36 in post-ER quality control of human alpha1-antitrypsin
GOA
curator
UniProt
UniProt protein ID
P01009
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01009
determination method
IPI
retrieved
8 April 2019
stated in
Grp78, Grp94, and Grp170 interact with alpha1-antitrypsin mutants that are retained in the endoplasmic reticulum
GOA
curator
UniProt
UniProt protein ID
P01009
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01009
determination method
IPI
retrieved
8 April 2019
stated in
SERPINA2 is a novel gene with a divergent function from SERPINA1
GOA
curator
UniProt
UniProt protein ID
P01009
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01009
determination method
IPI
retrieved
8 April 2019
stated in
Characterization of the enzymatic activity of human kallikrein 6: Autoactivation, substrate specificity, and regulation by inhibitors
GOA
curator
UniProt
UniProt protein ID
P01009
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01009
determination method
IPI
retrieved
8 April 2019
stated in
Trypsin-2 degrades human type II collagen and is expressed and activated in mesenchymally transformed rheumatoid arthritis synovitis tissue
GOA
curator
UniProt
UniProt protein ID
P01009
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01009
determination method
IPI
retrieved
8 April 2019
stated in
Alpha 1-antitrypsin binds to and interferes with functionality of EspB from atypical and typical enteropathogenic Escherichia coli strains
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01009
determination method
IPI
retrieved
8 April 2019
stated in
Canonical inhibitor-like interactions explain reactivity of alpha1-proteinase inhibitor Pittsburgh and antithrombin with proteinases
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01009
determination method
IPI
retrieved
8 April 2019
stated in
Streptomyces erythraeus trypsin inactivates α1-antitrypsin
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01009
determination method
IPI
retrieved
8 April 2019
stated in
Simultaneous induction of the four subunits of the TRAP complex by ER stress accelerates ER degradation
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01009
determination method
IPI
retrieved
8 April 2019
stated in
Active site distortion is sufficient for proteinase inhibition by serpins: structure of the covalent complex of alpha1-proteinase inhibitor with porcine pancreatic elastase
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01009
determination method
IPI
retrieved
8 April 2019
stated in
Structure of a serpin-protease complex shows inhibition by deformation
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01009
determination method
IPI
cell component
extracellular space
determination method
IDA
IEA
IMP
6 references
retrieved
17 October 2017
stated in
Trypsin-2 degrades human type II collagen and is expressed and activated in mesenchymally transformed rheumatoid arthritis synovitis tissue
GOA
curator
UniProt
UniProt protein ID
P01009
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P01009&geneProductId=UniProtKB:P01009
determination method
IMP
retrieved
17 October 2017
stated in
GOA
curator
InterPro
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P01009&geneProductId=UniProtKB:P01009
determination method
IEA
retrieved
17 October 2017
stated in
Human colostrum: identification of minor proteins in the aqueous phase by proteomics
GOA
curator
UniProt
UniProt protein ID
P01009
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P01009&geneProductId=UniProtKB:P01009
determination method
IDA
retrieved
17 October 2017
stated in
Human neutrophils secrete bioactive paucimannosidic proteins from azurophilic granules into pathogen-infected sputum
GOA
curator
UniProt
UniProt protein ID
P01009
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P01009&geneProductId=UniProtKB:P01009
determination method
IDA
retrieved
17 October 2017
stated in
Shotgun proteomics reveals specific modulated protein patterns in tears of patients with primary open angle glaucoma naïve to therapy
GOA
curator
UniProt
UniProt protein ID
P01009
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P01009&geneProductId=UniProtKB:P01009
determination method
IDA
retrieved
17 October 2017
stated in
Proteolytic cleavage and inactivation of alpha 2-plasmin inhibitor and C1 inactivator by human polymorphonuclear leukocyte elastase
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P01009&geneProductId=UniProtKB:P01009
determination method
IDA
extracellular space
determination method
HDA
IBA
IDA
IEA
IMP
7 references
retrieved
8 April 2019
stated in
Trypsin-2 degrades human type II collagen and is expressed and activated in mesenchymally transformed rheumatoid arthritis synovitis tissue
GOA
curator
UniProt
UniProt protein ID
P01009
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01009
determination method
IMP
retrieved
8 April 2019
stated in
GOA
curator
InterPro
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01009
determination method
IEA
retrieved
8 April 2019
stated in
Human neutrophils secrete bioactive paucimannosidic proteins from azurophilic granules into pathogen-infected sputum
GOA
curator
UniProt
UniProt protein ID
P01009
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01009
determination method
IDA
retrieved
8 April 2019
stated in
Proteolytic cleavage and inactivation of alpha 2-plasmin inhibitor and C1 inactivator by human polymorphonuclear leukocyte elastase
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01009
determination method
IDA
retrieved
8 April 2019
stated in
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01009
determination method
IBA
retrieved
8 April 2019
stated in
Human colostrum: identification of minor proteins in the aqueous phase by proteomics
GOA
curator
UniProt
UniProt protein ID
P01009
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01009
determination method
HDA
retrieved
8 April 2019
stated in
Shotgun proteomics reveals specific modulated protein patterns in tears of patients with primary open angle glaucoma naïve to therapy
GOA
curator
UniProt
UniProt protein ID
P01009
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01009
determination method
HDA
biological process

Identifiers

CAS Registry Number
9041-92-3
1 reference
stated in
DrugBank
DrugBank ID
00058
language of work or name
English
title
Alpha-1-proteinase inhibitor (English)
publication date
17 November 2015
EC number
232-924-7
0 references
ECHA Substance Infocard ID
100.029.919
1 reference
stated in
ECHA Substance Infocard database
ECHA Substance Infocard ID
100.029.919
retrieved
27 December 2018
title
Trypsin inhibitor, α1- (English)
quotation
CAS no.: 9041-92-3 (English)
MeSH descriptor ID
D000515
subject named as
alpha 1-Antitrypsin
0 references
MeSH tree code
D12.644.861.035
0 references
D12.776.124.050.070
0 references
D12.776.395.068
0 references
D12.776.872.035
0 references
RxNorm ID
991743
0 references
UNII
F43I396OIS
0 references
NDF-RT ID
N0000147633
0 references
Reactome ID
R-HSA-141755
0 references
R-HSA-6804783
0 references
R-HSA-8956709
0 references
R-HSA-141757
0 references
Ensembl protein ID
PDB structure ID
 
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