(Q29347088)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21602469%20AND%20SRC:MED&resulttype=core&format=json

1 February 2020

title

Vascular oxidative stress in aging: a homeostatic failure due to dysregulation of NRF2-mediated antioxidant response (English)

1 reference

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1 February 2020

8

1 reference

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1 February 2020

William E. Sonntag

9

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21602469%20AND%20SRC:MED&resulttype=core&format=json

1 February 2020

6

Gyorgy Losonczy

1 reference

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1 February 2020

1

Zoltan Ungvari

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21602469%20AND%20SRC:MED&resulttype=core&format=json

1 February 2020

author name string

Lora Bailey-Downs

2

1 reference

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1 February 2020

Danuta Sosnowska

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21602469%20AND%20SRC:MED&resulttype=core&format=json

1 February 2020

Tripti Gautam

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21602469%20AND%20SRC:MED&resulttype=core&format=json

1 February 2020

Peter Koncz

5

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21602469%20AND%20SRC:MED&resulttype=core&format=json

1 February 2020

Praveen Ballabh

7

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21602469%20AND%20SRC:MED&resulttype=core&format=json

1 February 2020

Anna Csiszar

10

1 reference

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1 February 2020

publication date

20 May 2011

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21602469%20AND%20SRC:MED&resulttype=core&format=json

American Journal of Physiology Heart and Circulatory Physiology

1 February 2020

published in

1 reference

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1 February 2020

volume

301

1 reference

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1 February 2020

issue

2

1 reference

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1 February 2020

page(s)

H363-72

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21602469%20AND%20SRC:MED&resulttype=core&format=json

Rapamycin, but not resveratrol or simvastatin, extends life span of genetically heterogeneous mice

1 February 2020

cites work

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3154665

Suppression of oxidative stress by resveratrol after isometric contractions in gastrocnemius muscles of aged mice

11 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3154665

Aging impairs the expression of the catalytic subunit of glutamate cysteine ligase in soleus muscle under stress

11 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3154665

Cell stress and aging: new emphasis on multiplex resistance mechanisms

11 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3154665

Nrf2 is critical in defense against high glucose-induced oxidative damage in cardiomyocytes

11 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3154665

Resveratrol delays age-related deterioration and mimics transcriptional aspects of dietary restriction without extending life span

11 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3154665

Nitric oxide and peroxynitrite in health and disease

11 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3154665

Age-associated vascular oxidative stress, Nrf2 dysfunction, and NF-{kappa}B activation in the nonhuman primate Macaca mulatta.

11 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3154665

Adaptive induction of NF-E2-related factor-2-driven antioxidant genes in endothelial cells in response to hyperglycemia

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3154665

Vasoprotective effects of life span-extending peripubertal GH replacement in Lewis dwarf rats

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3154665

Resveratrol improves left ventricular diastolic relaxation in type 2 diabetes by inhibiting oxidative/nitrative stress: in vivo demonstration with magnetic resonance imaging

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3154665

Mechanisms of vascular aging: new perspectives.

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3154665

Resveratrol confers endothelial protection via activation of the antioxidant transcription factor Nrf2.

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3154665

Mice deficient in both Mn superoxide dismutase and glutathione peroxidase-1 have increased oxidative damage and a greater incidence of pathology but no reduction in longevity

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3154665

Resveratrol attenuates mitochondrial oxidative stress in coronary arterial endothelial cells

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3154665

Overexpression of Mn superoxide dismutase does not increase life span in mice

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3154665

Anti-oxidative and anti-inflammatory vasoprotective effects of caloric restriction in aging: role of circulating factors and SIRT1.

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3154665

Resveratrol improves endothelial function: role of TNF{alpha} and vascular oxidative stress

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3154665

Testing hypotheses of aging in long-lived mice of the genus Peromyscus: association between longevity and mitochondrial stress resistance, ROS detoxification pathways, and DNA repair efficiency

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3154665

Does damage to DNA and other macromolecules play a role in aging? If so, how?

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3154665

Differential regulation of hepatic heme oxygenase-1 protein with aging and heat stress

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3154665

Longevity is associated with increased vascular resistance to high glucose-induced oxidative stress and inflammatory gene expression in Peromyscus leucopus

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3154665

Endothelial function and vascular oxidative stress in long-lived GH/IGF-deficient Ames dwarf mice

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3154665

Predictors of cognitive decline in older individuals with diabetes

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3154665

Activation of NF-E2-related factor-2 reverses biochemical dysfunction of endothelial cells induced by hyperglycemia linked to vascular disease

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3154665

Inflammation and endothelial dysfunction during aging: role of NF-kappaB

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3154665

Oxidative stress in vascular senescence: lessons from successfully aging species

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3154665

Mechanisms underlying caloric restriction and lifespan regulation: implications for vascular aging.

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3154665

Nrf2 mediates cancer protection but not prolongevity induced by caloric restriction

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3154665

Keap1/Nrf2 signaling regulates oxidative stress tolerance and lifespan in Drosophila

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3154665

Simultaneous detection of apoptosis and mitochondrial superoxide production in live cells by flow cytometry and confocal microscopy

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3154665

Direct evidence of endothelial oxidative stress with aging in humans: relation to impaired endothelium-dependent dilation and upregulation of nuclear factor-kappaB.

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3154665

Vascular aging in the longest-living rodent, the naked mole rat.

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3154665

Resveratrol increases vascular oxidative stress resistance

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3154665

Vasculoprotective effects of anti-tumor necrosis factor-alpha treatment in aging

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3154665

NRF2-dependent glutamate-L-cysteine ligase catalytic subunit expression mediates insulin protection against hyperglycemia- induced brain endothelial cell apoptosis

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3154665

Regulation of bone morphogenetic protein-2 expression in endothelial cells: role of nuclear factor-kappaB activation by tumor necrosis factor-alpha, H2O2, and high intravascular pressure

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3154665

Decline in transcriptional activity of Nrf2 causes age-related loss of glutathione synthesis, which is reversible with lipoic acid

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3154665

Reduced release of nitric oxide to shear stress in mesenteric arteries of aged rats

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3154665

Aging-induced phenotypic changes and oxidative stress impair coronary arteriolar function

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3154665

Superoxide excess in hypertension and aging: a common cause of endothelial dysfunction

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3154665

Enhanced peroxynitrite formation is associated with vascular aging

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3154665

Oxidized phospholipids regulate expression of ATF4 and VEGF in endothelial cells via NRF2-dependent mechanism: novel point of convergence between electrophilic and unfolded protein stress pathways.

3 June 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPHEART.01134.2010

Laminar flow induction of antioxidant response element-mediated genes in endothelial cells. A novel anti-inflammatory mechanism

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPHEART.01134.2010

Age-accelerated atherosclerosis correlates with failure to upregulate antioxidant genes

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPHEART.01134.2010

Vascular superoxide and hydrogen peroxide production and oxidative stress resistance in two closely related rodent species with disparate longevity

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPHEART.01134.2010

Resveratrol attenuates TNF-alpha-induced activation of coronary arterial endothelial cells: role of NF-kappaB inhibition.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPHEART.01134.2010

Proinflammatory phenotype of coronary arteries promotes endothelial apoptosis in aging

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPHEART.01134.2010

Xanthine oxidase does not contribute to impaired peripheral conduit artery endothelium-dependent dilatation with ageing

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPHEART.01134.2010

Effect of acute and chronic ascorbic acid on flow-mediated dilatation with sedentary and physically active human ageing

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPHEART.01134.2010

KLF2 primes the antioxidant transcription factor Nrf2 for activation in endothelial cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPHEART.01134.2010

Deletion of p66shc gene protects against age-related endothelial dysfunction

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPHEART.01134.2010

High-dose ascorbic acid infusion abolishes chronic vasoconstriction and restores resting leg blood flow in healthy older men.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPHEART.01134.2010

Nrf2 regulates antioxidant gene expression evoked by oxidized phospholipids in endothelial cells and murine arteries in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPHEART.01134.2010

Nrf2, a guardian of healthspan and gatekeeper of species longevity

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPHEART.01134.2010

Poly(ADP-Ribose) polymerase is activated in subjects at risk of developing type 2 diabetes and is associated with impaired vascular reactivity

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPHEART.01134.2010

High pressure induces superoxide production in isolated arteries via protein kinase C-dependent activation of NAD(P)H oxidase

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPHEART.01134.2010

Shear stress stabilizes NF-E2-related factor 2 and induces antioxidant genes in endothelial cells: role of reactive oxygen/nitrogen species.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPHEART.01134.2010

Activation of Nrf2 in endothelial cells protects arteries from exhibiting a proinflammatory state.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPHEART.01134.2010

Hyperglycemia induces oxidative and nitrosative stress and increases renal functional impairment in Nrf2-deficient mice.

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3154665

Impaired flow-mediated dilation with age is not explained by L-arginine bioavailability or endothelial asymmetric dimethylarginine protein expression

26 November 2018

1 reference

12 December 2020

Comparison of endothelial function, O2-* and H2O2 production, and vascular oxidative stress resistance between the longest-living rodent, the naked mole rat, and mice

1 reference

12 December 2020

Dysregulation of mitochondrial biogenesis in vascular endothelial and smooth muscle cells of aged rats

1 reference

12 December 2020

Increased mitochondrial H2O2 production promotes endothelial NF-kappaB activation in aged rat arteries

1 reference

12 December 2020

SKNy worms and long life

1 reference

12 December 2020

10.1152/AJPHEART.01134.2010

Identifiers

DOI

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21602469%20AND%20SRC:MED&resulttype=core&format=json

1 February 2020

1 reference

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21602469%20AND%20SRC:MED&resulttype=core&format=json

1 February 2020

PubMed publication ID

21602469

2 references