(Q30009224)

21 May 2017

title

Autoinhibition of Bruton's tyrosine kinase (Btk) and activation by soluble inositol hexakisphosphate (English)

1 reference

21 May 2017

0 references

7

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Erik M Vogan

object named as

Erik M Vogan

2

0 references

Stephen C. Harrison

6

object named as

Stephen C Harrison

1 reference

21 May 2017

Qi Wang

1

1 reference

21 May 2017

Laura M Nocka

3

1 reference

21 May 2017

Connor E Rosen

4

1 reference

21 May 2017

Julie A Zorn

5

1 reference

21 May 2017

language of work or name

English

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publication date

20 February 2015

1 reference

21 May 2017

1 reference

21 May 2017

volume

4

1 reference

Deciphering key features in protein structures with the new ENDscript server

21 May 2017

cites work

1 reference

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Structural and functional insights into the regulation mechanism of CK2 by IP6 and the intrinsically disordered protein Nopp140

22 May 2017

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Class I HDACs Share a Common Mechanism of Regulation by Inositol Phosphates

22 May 2017

1 reference

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GROMACS 4.5: a high-throughput and highly parallel open source molecular simulation toolkit

22 May 2017

1 reference

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Structure of HDAC3 bound to co-repressor and inositol tetraphosphate

22 May 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4384635

Overview of the CCP4 suite and current developments

22 May 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4384635

Crystal Structure of Human AKT1 with an Allosteric Inhibitor Reveals a New Mode of Kinase Inhibition

22 May 2017

1 reference

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Improved side-chain torsion potentials for the Amber ff99SB protein force field

22 May 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4384635

Role of a novel PH-kinase domain interface in PKB/Akt regulation: structural mechanism for allosteric inhibition

22 May 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4384635

Structural coupling of SH2-kinase domains links Fes and Abl substrate recognition and kinase activation

22 May 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4384635

Membrane recognition by phospholipid-binding domains

22 May 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4384635

Version 1.2 of the Crystallography and NMR system

22 May 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4384635

Clustal W and Clustal X version 2.0

22 May 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4384635

PDB2PQR: expanding and upgrading automated preparation of biomolecular structures for molecular simulations

22 May 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4384635

Mechanism of auxin perception by the TIR1 ubiquitin ligase

22 May 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4384635

Coot: model-building tools for molecular graphics

22 May 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4384635

PDB2PQR: an automated pipeline for the setup of Poisson-Boltzmann electrostatics calculations

22 May 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4384635

Generation, representation and flow of phase information in structure determination: recent developments in and around SHARP 2.0

22 May 2017

2 references

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4384635

22 May 2017

https://api.crossref.org/works/10.7554%2FELIFE.06074

Structural basis for the autoinhibition of c-Abl tyrosine kinase

22 May 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4384635

PHENIX: building new software for automated crystallographic structure determination

22 May 2017

2 references

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4384635

22 May 2017

https://api.crossref.org/works/10.7554%2FELIFE.06074

Competing modes of self-association in the regulatory domains of Bruton's tyrosine kinase: intramolecular contact versus asymmetric homodimerization

22 May 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4384635

Back in the water: the return of the inositol phosphates

22 May 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4384635

Dimer formation through domain swapping in the crystal structure of the Grb2-SH2-Ac-pYVNV complex

22 May 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4384635

Solution structure of the human BTK SH3 domain complexed with a proline-rich peptide from p120cbl

22 May 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4384635

A phospholipase C-dependent inositol polyphosphate kinase pathway required for efficient messenger RNA export

22 May 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4384635

Structure of the PH domain from Bruton's tyrosine kinase in complex with inositol 1,3,4,5-tetrakisphosphate

22 May 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4384635

The Syk family of protein tyrosine kinases in T-cell activation and development

22 May 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4384635

Crystallography & NMR System: A New Software Suite for Macromolecular Structure Determination

22 May 2017

2 references

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4384635

22 May 2017

https://api.crossref.org/works/10.7554%2FELIFE.06074

Solution structure of the SH3 domain from Bruton's tyrosine kinase

22 May 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4384635

Structure of the PH domain and Btk motif from Bruton's tyrosine kinase: molecular explanations for X-linked agammaglobulinaemia

22 May 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4384635

Crystal structure of the Src family tyrosine kinase Hck

22 May 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4384635

Three-dimensional structure of the tyrosine kinase c-Src

22 May 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4384635

Structural basis for activation of human lymphocyte kinase Lck upon tyrosine phosphorylation

22 May 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4384635

VMD: visual molecular dynamics

22 May 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4384635

Regulation of Btk function by a major autophosphorylation site within the SH3 domain

22 May 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4384635

Activation of BTK by a phosphorylation mechanism initiated by SRC family kinases

22 May 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4384635

Structure of the high affinity complex of inositol trisphosphate with a phospholipase C pleckstrin homology domain

22 May 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4384635

Signal transduction by lymphocyte antigen receptors

22 May 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4384635

Binding of beta gamma subunits of heterotrimeric G proteins to the PH domain of Bruton tyrosine kinase

22 May 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4384635

Crystal structure of the mammalian Grb2 adaptor

22 May 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4384635

Structure of the binding site for inositol phosphates in a PH domain

22 May 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4384635

Tyrosine phosphorylation and activation of Bruton tyrosine kinase upon Fc epsilon RI cross-linking

22 May 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4384635

Improved methods for building protein models in electron density maps and the location of errors in these models

22 May 2017

2 references

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4384635

22 May 2017

https://api.crossref.org/works/10.7554%2FELIFE.06074

Activation of the Src-family tyrosine kinase Hck by SH3 domain displacement

22 May 2017

1 reference

https://api.crossref.org/works/10.7554%2FELIFE.06074

Protein kinases: evolution of dynamic regulatory proteins

22 May 2017

1 reference

https://api.crossref.org/works/10.7554%2FELIFE.06074

Activation loop dynamics determine the different catalytic efficiencies of B cell- and T cell-specific tec kinases.

22 May 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4384635

Monovalent and multivalent ligation of the B cell receptor exhibit differential dependence upon Syk and Src family kinases

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4384635

ABL1 fusion genes in hematological malignancies: a review

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4384635

Regulation of BCR signaling

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4384635

Inositol pyrophosphates inhibit Akt signaling, thereby regulating insulin sensitivity and weight gain

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4384635

Specific Btk inhibition suppresses B cell- and myeloid cell-mediated arthritis

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4384635

T-cell signaling regulated by the Tec family kinase, Itk.

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4384635

The SYK tyrosine kinase: a crucial player in diverse biological functions

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4384635

ZAP-70: an essential kinase in T-cell signaling

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4384635

Flexibility and charge asymmetry in the activation loop of Src tyrosine kinases

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4384635

Src kinase activation: A switched electrostatic network

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4384635

Organization of the SH3-SH2 unit in active and inactive forms of the c-Abl tyrosine kinase

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4384635

High yield bacterial expression of active c-Abl and c-Src tyrosine kinases

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4384635

Bruton's tyrosine kinase: cell biology, sequence conservation, mutation spectrum, siRNA modifications, and expression profiling.

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4384635

B cell antigen receptor signaling 101.

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4384635

Conformation of full-length Bruton tyrosine kinase (Btk) from synchrotron X-ray solution scattering.

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4384635

Bruton's tyrosine kinase is a Toll/interleukin-1 receptor domain-binding protein that participates in nuclear factor kappaB activation by Toll-like receptor 4.

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4384635

Assessing the omnipotence of inositol hexakisphosphate

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4384635

Domain interactions in protein tyrosine kinase Csk.

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4384635

The SH3 domain of Bruton's tyrosine kinase displays altered ligand binding properties when auto-phosphorylated in vitro

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4384635

Direct stimulation of Bruton's tyrosine kinase by G(q)-protein alpha-subunit

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4384635

Deficient expression of a B cell cytoplasmic tyrosine kinase in human X-linked agammaglobulinemia

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4384635

The B-cell antigen receptor: structure and function of primary, secondary, tertiary and quaternary components

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4384635

Occurrence and extracellular actions of inositol pentakis- and hexakisphosphate in mammalian brain

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4384635

Observation of inositol pentakis- and hexakis-phosphates in mammalian tissues by 31P NMR.

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4384635

Improvement of macromolecular electron-density maps by the simultaneous application of real and reciprocal space constraints.

3 June 2018

1 reference

https://api.crossref.org/works/10.7554%2FELIFE.06074

Comparative protein structure modeling using Modeller

21 January 2018

1 reference

https://api.crossref.org/works/10.7554%2FELIFE.06074

Function of Bruton's tyrosine kinase during B cell development is partially independent of its catalytic activity.

21 January 2018

1 reference

https://api.crossref.org/works/10.7554%2FELIFE.06074

Processing of X-ray diffraction data collected in oscillation mode

21 January 2018

1 reference

https://api.crossref.org/works/10.7554%2FELIFE.06074

Improved Fourier coefficients for maps using phases from partial structures with errors

21 January 2018

1 reference

https://api.crossref.org/works/10.7554%2FELIFE.06074

Competing modes of self-association in the regulatory domains of Bruton's tyrosine kinase: Intramolecular contact versus asymmetric homodimerization

21 January 2018

1 reference

https://api.crossref.org/works/10.7554%2FELIFE.06074

c-Abl has high intrinsic tyrosine kinase activity that is stimulated by mutation of the Src homology 3 domain and by autophosphorylation at two distinct regulatory tyrosines

21 January 2018

1 reference

12 December 2020

Positive regulation of Itk PH domain function by soluble IP4

1 reference

12 December 2020

Structure and polymorphism of lipids: x-ray diffraction study of the system formed from beef heart mitochondria lipids and water

1 reference

12 December 2020

Characterization of pp60c-src Tyrosine Kinase Activities Using a Continuous Assay: Autoactivation of the Enzyme Is an Intermolecular Autophosphorylation Process

1 reference

12 December 2020

Identifiers

DOI

10.7554/ELIFE.06074

1 reference

21 May 2017

0 references

1 reference