(Q30009947)

English

Enhanced SH3/linker interaction overcomes Abl kinase activation by gatekeeper and myristic acid binding pocket mutations and increases sensitivity to small molecule inhibitors

scientific article published on 9 January 2013

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scholarly article

1 reference

Europe PubMed Central

PubMed publication ID

21 May 2017

Enhanced SH3/linker interaction overcomes Abl kinase activation by gatekeeper and myristic acid binding pocket mutations and increases sensitivity to small molecule inhibitors (English)

1 reference

Europe PubMed Central

PubMed publication ID

21 May 2017

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1 reference

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inferred from title

object named as

John R Engen

5

0 references

author name string

Shoghag Panjarian

1

1 reference

Europe PubMed Central

PubMed publication ID

21 May 2017

Roxana E Iacob

2

1 reference

Europe PubMed Central

PubMed publication ID

21 May 2017

Shugui Chen

3

1 reference

Europe PubMed Central

PubMed publication ID

21 May 2017

Thomas E Wales

4

1 reference

Europe PubMed Central

PubMed publication ID

21 May 2017

Thomas E Smithgall

6

1 reference

Europe PubMed Central

PubMed publication ID

21 May 2017

language of work or name

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publication date

9 January 2013

1 reference

Europe PubMed Central

PubMed publication ID

21 May 2017

Journal of Biological Chemistry

1 reference

Europe PubMed Central

PubMed publication ID

21 May 2017

288

1 reference

Europe PubMed Central

PubMed publication ID

21 May 2017

9

1 reference

Europe PubMed Central

PubMed publication ID

21 May 2017

6116-6129

1 reference

Europe PubMed Central

PubMed publication ID

21 May 2017

Allosteric interactions between the myristate- and ATP-site of the Abl kinase

1 reference

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Targeting Bcr–Abl by combining allosteric with ATP-binding-site inhibitors

1 reference

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Structural coupling of SH2-kinase domains links Fes and Abl substrate recognition and kinase activation

1 reference

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High-speed and high-resolution UPLC separation at zero degrees Celsius

1 reference

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Hydrogen exchange mass spectrometry for the analysis of protein dynamics

1 reference

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Structural basis for the autoinhibition of c-Abl tyrosine kinase

1 reference

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Crystal structures of the kinase domain of c-Abl in complex with the small molecule inhibitors PD173955 and imatinib (STI-571)

1 reference

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1 reference

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1 reference

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Crystal structure of the abl-SH3 domain complexed with a designed high-affinity peptide ligand: implications for SH3-ligand interactions

1 reference

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Two binding orientations for peptides to the Src SH3 domain: development of a general model for SH3-ligand interactions

1 reference

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Structural basis for the binding of proline-rich peptides to SH3 domains

1 reference

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Hydrogen exchange and structural dynamics of proteins and nucleic acids

2 references

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22 May 2017

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Expression of a Src family kinase in chronic myelogenous leukemia cells induces resistance to imatinib in a kinase-dependent manner

1 reference

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1 reference

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Conformational disturbance in Abl kinase upon mutation and deregulation

1 reference

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An inhibitor-resistant mutant of Hck protects CML cells against the antiproliferative and apoptotic effects of the broad-spectrum Src family kinase inhibitor A-419259.

1 reference

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Tyrosine phosphorylation in the SH3 domain disrupts negative regulatory interactions within the c-Abl kinase core

1 reference

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3 June 2018

Structure and dynamic regulation of Src-family kinases

1 reference

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3 June 2018

Abl N-terminal cap stabilization of SH3 domain dynamics

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3585049

3 June 2018

Src family kinases phosphorylate the Bcr-Abl SH3-SH2 region and modulate Bcr-Abl transforming activity

1 reference

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3 June 2018

Kinase domain mutants of Bcr-Abl exhibit altered transformation potency, kinase activity, and substrate utilization, irrespective of sensitivity to imatinib

1 reference

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Identification and characterization of EX1 kinetics in H/D exchange mass spectrometry by peak width analysis

1 reference

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UPLC/MS(E); a new approach for generating molecular fragment information for biomarker structure elucidation

1 reference

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Organization of the SH3-SH2 unit in active and inactive forms of the c-Abl tyrosine kinase

1 reference

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Allosteric inhibitors of Bcr-abl-dependent cell proliferation

1 reference

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Imatinib as a paradigm of targeted therapies

1 reference

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1 reference

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Regulation of the c-Abl and Bcr-Abl tyrosine kinases

1 reference

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Mechanisms and implications of imatinib resistance mutations in BCR-ABL.

1 reference

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A myristoyl/phosphotyrosine switch regulates c-Abl

1 reference

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An intramolecular SH3-domain interaction regulates c-Abl activity

1 reference

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A coiled-coil oligomerization domain of Bcr is essential for the transforming function of Bcr-Abl oncoproteins

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1 reference

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1 reference

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1 reference

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c-Abl has high intrinsic tyrosine kinase activity that is stimulated by mutation of the Src homology 3 domain and by autophosphorylation at two distinct regulatory tyrosines

1 reference

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12 December 2020

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