(Q37334825)

English

An inhibitor-resistant mutant of Hck protects CML cells against the antiproliferative and apoptotic effects of the broad-spectrum Src family kinase inhibitor A-419259.

scientific article published on 15 September 2008

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scholarly article

1 reference

Europe PubMed Central

PMC publication ID

19 August 2017

An inhibitor-resistant mutant of Hck protects CML cells against the antiproliferative and apoptotic effects of the broad-spectrum Src family kinase inhibitor A-419259. (English)

1 reference

Europe PubMed Central

PMC publication ID

19 August 2017

apoptotic process

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author name string

T Pene-Dumitrescu

1

1 reference

Europe PubMed Central

PMC publication ID

19 August 2017

L F Peterson

2

1 reference

Europe PubMed Central

PMC publication ID

19 August 2017

N J Donato

3

1 reference

Europe PubMed Central

PMC publication ID

19 August 2017

T E Smithgall

4

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Europe PubMed Central

PMC publication ID

19 August 2017

language of work or name

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publication date

15 September 2008

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Europe PubMed Central

PMC publication ID

19 August 2017

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Europe PubMed Central

PMC publication ID

19 August 2017

27

1 reference

Europe PubMed Central

PMC publication ID

19 August 2017

56

1 reference

Europe PubMed Central

PMC publication ID

19 August 2017

7055-7069

1 reference

Europe PubMed Central

PMC publication ID

19 August 2017

https://scigraph.springernature.com/pub.10.1038/onc.2008.330

0 references

Association between imatinib-resistant BCR-ABL mutation-negative leukemia and persistent activation of LYN kinase

1 reference

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Important therapeutic targets in chronic myelogenous leukemia

1 reference

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2-aminothiazole as a novel kinase inhibitor template. Structure-activity relationship studies toward the discovery of N-(2-chloro-6-methylphenyl)-2-[[6-[4-(2-hydroxyethyl)-1- piperazinyl)]-2-methyl-4-pyrimidinyl]amino)]-1,3-thiazole-5-carboxamide (d

1 reference

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Src family kinases phosphorylate the Bcr-Abl SH3-SH2 region and modulate Bcr-Abl transforming activity

1 reference

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HIV-1 Nef selectively activates Src family kinases Hck, Lyn, and c-Src through direct SH3 domain interaction

1 reference

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1 reference

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Activation of the Src family kinase Hck without SH3-linker release

1 reference

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Dual tyrosine kinase inhibitors in chronic myeloid leukemia.

1 reference

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Structure and regulation of Src family kinases

1 reference

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1 reference

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The molecular mechanism of chronic myelogenous leukemia and its therapeutic implications: studies in a murine model

1 reference

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The Src family kinase Hck couples BCR/ABL to STAT5 activation in myeloid leukemia cells.

1 reference

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Activation of STAT3 by the Src family kinase Hck requires a functional SH3 domain

1 reference

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1 reference

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SH3-dependent stimulation of Src-family kinase autophosphorylation without tail release from the SH2 domain in vivo

1 reference

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Clinical resistance to STI-571 cancer therapy caused by BCR-ABL gene mutation or amplification

1 reference

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A chemical switch for inhibitor-sensitive alleles of any protein kinase

1 reference

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1 reference

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Transformation of myeloid leukemia cells to cytokine independence by Bcr-Abl is suppressed by kinase-defective Hck

1 reference

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1 reference

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Reciprocal regulation of Hck activity by phosphorylation of Tyr(527) and Tyr(416). Effect of introducing a high affinity intramolecular SH2 ligand

1 reference

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Src family tyrosine kinases and growth factor signaling

1 reference

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SH2-kinase linker mutations release Hck tyrosine kinase and transforming activities in Rat-2 fibroblasts.

1 reference

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Crystal structure of Hck in complex with a Src family-selective tyrosine kinase inhibitor

1 reference

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Crystal structures of c-Src reveal features of its autoinhibitory mechanism

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Chronic myeloid leukemia

1 reference

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The Src family kinase Hck interacts with Bcr-Abl by a kinase-independent mechanism and phosphorylates the Grb2-binding site of Bcr

1 reference

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Transformation of hematopoietic cells by BCR/ABL requires activation of a PI-3k/Akt-dependent pathway.

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SH3-mediated Hck tyrosine kinase activation and fibroblast transformation by the Nef protein of HIV-1.

1 reference

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Constitutive activation of STAT5 by the BCR-ABL oncogene in chronic myelogenous leukemia

1 reference

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The proto-oncogene product p120CBL and the adaptor proteins CRKL and c-CRK link c-ABL, p190BCR/ABL and p210BCR/ABL to the phosphatidylinositol-3' kinase pathway.

1 reference

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SH2 domains recognize specific phosphopeptide sequences

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Association of phosphatidylinositol 3-kinase with SHC in chronic myelogeneous leukemia cells.

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Letter: A new consistent chromosomal abnormality in chronic myelogenous leukaemia identified by quinacrine fluorescence and Giemsa staining

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Induction of a chronic myelogenous leukemia-like syndrome in mice with v-abl and BCR/ABL.

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Establishment and characterization of a unique human cell line that proliferates dependently on GM-CSF, IL-3, or erythropoietin

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31 March 2020

Identifiers

10.1038/ONC.2008.330

1 reference

Europe PubMed Central

PMC publication ID

19 August 2017

release_fbzw77e7ezfu5judsrsb3jwtz4

1 reference

https://api.fatcat.wiki/v0/release/fbzw77e7ezfu5judsrsb3jwtz4

24 November 2022

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mapped directly with Wikidata item

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

19 August 2017

1 reference

Europe PubMed Central

PMC publication ID

19 August 2017

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