(Q35022540)

5 August 2017

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title

The molecular mechanism of chronic myelogenous leukemia and its therapeutic implications: studies in a murine model (English)

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5 August 2017

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Ruibao Ren

1

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5 August 2017

language of work or name

English

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publication date

1 December 2002

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5 August 2017

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5 August 2017

21

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5 August 2017

56

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5 August 2017

8629-8642

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https://scigraph.springernature.com/pub.10.1038/sj.onc.1206090

5 August 2017

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cites work

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NUP98 gene rearrangements and the clonal evolution of chronic myelogenous leukemia

21 January 2018

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The effect of interferon-alpha on beta-1 integrin mediated adhesion and growth regulation in chronic myelogenous leukemia

21 January 2018

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Chronic myeloid leukemia and interferon-alpha: a study of complete cytogenetic responders

21 January 2018

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The role of STATs in transcriptional control and their impact on cellular function

21 January 2018

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Tyrosyl phosphorylation and DNA binding activity of signal transducers and activators of transcription (STAT) proteins in hematopoietic cell lines transformed by Bcr/Abl

21 January 2018

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Failure of embryonic hematopoiesis and lethal hemorrhages in mouse embryos heterozygous for a knocked-in leukemia gene CBFB-MYH11.

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1206090

Inversion of chromosome 16 in accelerated phase of chronic myeloid leukaemia: report of a case and review of the literature.

21 January 2018

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Structural and signaling requirements for BCR-ABL-mediated transformation and inhibition of apoptosis

21 January 2018

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Human AML1/MDS1/EVI1 fusion protein induces an acute myelogenous leukemia (AML) in mice: a model for human AML

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1206090

Cooperation of BCR-ABL and AML1/MDS1/EVI1 in blocking myeloid differentiation and rapid induction of an acute myelogenous leukemia

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1206090

Induction of chronic myelogenous leukemia in mice by the P210bcr/abl gene of the Philadelphia chromosome

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1206090

Blast crisis in a murine model of chronic myelogenous leukemia

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1206090

Expression of interferon consensus sequence binding protein induces potent immunity against BCR/ABL-induced leukemia.

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1206090

Effects of a selective inhibitor of the Abl tyrosine kinase on the growth of Bcr-Abl positive cells

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1206090

Hematologic disease induced in BALB/c mice by a bcr-abl retrovirus is influenced by the infection conditions

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1206090

Regulated expression of P210 Bcr-Abl during embryonic stem cell differentiation stimulates multipotential progenitor expansion and myeloid cell fate

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1206090

The biology of chronic myeloid leukemia

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1206090

Regulation of apoptosis in myeloid cells by interferon consensus sequence-binding protein

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1206090

Efficient transplantation of BCR-ABL-induced chronic myelogenous leukemia-like syndrome in mice

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1206090

Alternative signals to RAS for hematopoietic transformation by the BCR-ABL oncogene

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1206090

Chronic myeloid leukemia: current treatment options

21 January 2018

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Oligomerization of the ABL tyrosine kinase by the Ets protein TEL in human leukemia

21 January 2018

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Clinical resistance to STI-571 cancer therapy caused by BCR-ABL gene mutation or amplification

21 January 2018

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Point mutations in the FLT3 gene in AML.

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1206090

Bcr-Abl has a greater intrinsic capacity than v-Abl to induce the neoplastic expansion of myeloid cells

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1206090

Bcr-Abl with an SH3 deletion retains the ability To induce a myeloproliferative disease in mice, yet c-Abl activated by an SH3 deletion induces only lymphoid malignancy

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206090

Expression of interferon consensus sequence binding protein (ICSBP) is downregulated in Bcr-Abl-induced murine chronic myelogenous leukemia-like disease, and forced coexpression of ICSBP inhibits Bcr-Abl-induced myeloproliferative disorder

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1206090

The role of interferon regulatory factors in the interferon system and cell growth control

21 January 2018

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High-titer retroviral vectors for efficient transduction of functional genes into murine hematopoietic stem cells

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1206090

The coiled-coil domain and Tyr177 of bcr are required to induce a murine chronic myelogenous leukemia-like disease by bcr/abl.

21 January 2018

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Acute leukaemia in bcr/abl transgenic mice

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1206090

Immunodeficiency and chronic myelogenous leukemia-like syndrome in mice with a targeted mutation of the ICSBP gene

21 January 2018

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Reversibility of acute B-cell leukaemia induced by BCR-ABL1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206090

P210 and P190(BCR/ABL) induce the tyrosine phosphorylation and DNA binding activity of multiple specific STAT family members

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1206090

Autocrine production and action of IL-3 and granulocyte colony-stimulating factor in chronic myeloid leukemia.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206090

Hematologic and cytogenetic responses to imatinib mesylate in chronic myelogenous leukemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206090

Induction of a chronic myelogenous leukemia-like syndrome in mice with v-abl and BCR/ABL.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206090

Chronic myeloid leukemia cells resistant to interferon-alpha lack STAT1 expression

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206090

Interleukin 3 and granulocyte-macrophage colony-stimulating factor are not required for induction of chronic myeloid leukemia-like myeloproliferative disease in mice by BCR/ABL.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206090

The P190, P210, and P230 forms of the BCR/ABL oncogene induce a similar chronic myeloid leukemia-like syndrome in mice but have different lymphoid leukemogenic activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206090

In vitro transformation of immature hematopoietic cells by the P210 BCR/ABL oncogene product of the Philadelphia chromosome

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206090

A coiled-coil oligomerization domain of Bcr is essential for the transforming function of Bcr-Abl oncoproteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206090

Targeted disruption of the Stat1 gene in mice reveals unexpected physiologic specificity in the JAK-STAT signaling pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206090

The growing family of interferon regulatory factors.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206090

Signal transducer and activator of transcription (STAT)5 activation by BCR/ABL is dependent on intact Src homology (SH)3 and SH2 domains of BCR/ABL and is required for leukemogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206090

Hematopoiesis in the fetal liver is impaired by targeted mutagenesis of a gene encoding a non-DNA binding subunit of the transcription factor, polyomavirus enhancer binding protein 2/core binding factor

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206090

Chronic myelogenous leukaemia--new therapeutic principles.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206090

AML1, the target of multiple chromosomal translocations in human leukemia, is essential for normal fetal liver hematopoiesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206090

Protein modules and signalling networks

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206090

Production of high-titer helper-free retroviruses by transient transfection

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206090

21 January 2018

Autoinhibition of c-Abl

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206090

Dissecting the molecular mechanism of chronic myelogenous leukemia using murine models

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206090

The src homology 2 domain of Bcr/Abl is required for efficient induction of chronic myeloid leukemia-like disease in mice but not for lymphoid leukemogenesis or activation of phosphatidylinositol 3-kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206090

Molecular studies in chronic myeloid leukemia patients treated with tyrosine kinase inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206090

Fetal anemia and apoptosis of red cell progenitors in Stat5a-/-5b-/- mice: a direct role for Stat5 in Bcl-X(L) induction

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206090

Interferon-alfa-based treatment of chronic myeloid leukemia and implications of signal transduction inhibition

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206090

ICSBP directs bipotential myeloid progenitor cells to differentiate into mature macrophages.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206090

Dual functions of the AML1/Evi-1 chimeric protein in the mechanism of leukemogenesis in t(3;21) leukemias

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206090

Stat5a and Stat5b proteins have essential and nonessential, or redundant, roles in cytokine responses

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206090

Retroviral transduction models of Ph+ leukemia: advantages and limitations for modeling human hematological malignancies in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206090

Integrin-mediated regulation of hematopoiesis: do BCR/ABL-induced defects in integrin function underlie the abnormal circulation and proliferation of CML progenitors?

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206090

Disruption of the Cbfa2 gene causes necrosis and hemorrhaging in the central nervous system and blocks definitive hematopoiesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206090

The t(8;21) fusion product, AML-1-ETO, associates with C/EBP-alpha, inhibits C/EBP-alpha-dependent transcription, and blocks granulocytic differentiation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206090

Establishment of a murine model for therapy-treated chronic myelogenous leukemia using the tyrosine kinase inhibitor STI571.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206090

Modeling Philadelphia chromosome positive leukemias

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206090

Blocking of EGF-dependent cell proliferation by EGF receptor kinase inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206090

Embryonic lethality and impairment of haematopoiesis in mice heterozygous for an AML1-ETO fusion gene.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206090

The NH(2)-terminal coiled-coil domain and tyrosine 177 play important roles in induction of a myeloproliferative disease in mice by Bcr-Abl

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206090

The SH2 domain of bcr-Abl is not required to induce a murine myeloproliferative disease; however, SH2 signaling influences disease latency and phenotype

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206090

Signaling pathways activated by oncogenic forms of Abl tyrosine kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206090

Expression of nuclear transcription factor interferon consensus sequence binding protein in chronic myeloid leukemia correlates with pretreatment risk features and cytogenetic response to interferon-alpha

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206090

Chronic myelogenous leukemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206090

7 January 2021

bcr-abl, the hallmark of chronic myeloid leukaemia in man, induces multiple haemopoietic neoplasms in mice.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206090

7 January 2021

Deletion of an N-terminal regulatory domain of the c-abl tyrosine kinase activates its oncogenic potential

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206090

7 January 2021

Humanbcr-abl gene has a lethal effect on embryogenesis

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206090

7 January 2021

The fusion of TEL and ABL in human acute lymphoblastic leukaemia is a rare event

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206090

7 January 2021

Bcr-Abl kinase promotes cell cycle entry of primary myeloid CML cells in the absence of growth factors

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206090

7 January 2021

BCR-ABL gene variants.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206090

7 January 2021

Requirement for the transcription factor LSIRF/IRF4 for mature B and T lymphocyte function

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206090

7 January 2021

Signal transduction pathways involved in BCR-ABL transformation

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206090

7 January 2021

MDS1/EVI1 enhances TGF-beta1 signaling and strengthens its growth-inhibitory effect but the leukemia-associated fusion protein AML1/MDS1/EVI1, product of the t(3;21), abrogates growth-inhibition in response to TGF-beta1.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206090

7 January 2021

Identifiers

DOI

10.1038/SJ.ONC.1206090

1 reference

Dimensions Publication ID

5 August 2017

1019330230

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Fatcat ID

release_ajht2ynlizeb7ccarbdolungam

1 reference

Fatcat

https://api.fatcat.wiki/v0/release/ajht2ynlizeb7ccarbdolungam

24 November 2022

mapped directly with Wikidata item

1 reference