(Q34980358)

5 August 2017

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title

Dissecting the molecular mechanism of chronic myelogenous leukemia using murine models (English)

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5 August 2017

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1 reference

Ruibao Ren

1

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5 August 2017

publication date

1 August 2002

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5 August 2017

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5 August 2017

volume

43

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5 August 2017

issue

8

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5 August 2017

page(s)

1549-1561

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The biology of chronic myeloid leukemia

5 August 2017

cites work

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21 January 2018

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21 January 2018

Chronic myeloid leukemia

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Signaling pathways activated by oncogenic forms of Abl tyrosine kinase

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Tyrosine kinase activity and transformation potency of bcr-abl oncogene products.

21 January 2018

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Effects of a selective inhibitor of the Abl tyrosine kinase on the growth of Bcr-Abl positive cells

21 January 2018

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Clinical resistance to STI-571 cancer therapy caused by BCR-ABL gene mutation or amplification

21 January 2018

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Growth factor independence and BCR/ABL transformation: promise and pitfalls of murine model systems and assays

21 January 2018

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Retroviral transduction models of Ph+ leukemia: advantages and limitations for modeling human hematological malignancies in mice

21 January 2018

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Oncogenic ras provokes premature cell senescence associated with accumulation of p53 and p16INK4a

21 January 2018

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Creation of human tumour cells with defined genetic elements

21 January 2018

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A model of human p210(bcr/ABL)-mediated chronic myelogenous leukemia by transduction of primary normal human CD34(+) cells with a BCR/ABL-containing retroviral vector

21 January 2018

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Modeling Philadelphia chromosome positive leukemias

21 January 2018

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Acute leukaemia in bcr/abl transgenic mice

21 January 2018

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Reversibility of acute B-cell leukaemia induced by BCR-ABL1.

21 January 2018

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Induction of chronic myelogenous leukemia in mice by the P210bcr/abl gene of the Philadelphia chromosome

21 January 2018

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Induction of a chronic myelogenous leukemia-like syndrome in mice with v-abl and BCR/ABL.

21 January 2018

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Efficient transplantation of BCR-ABL-induced chronic myelogenous leukemia-like syndrome in mice

21 January 2018

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The P190, P210, and P230 forms of the BCR/ABL oncogene induce a similar chronic myeloid leukemia-like syndrome in mice but have different lymphoid leukemogenic activity

21 January 2018

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High-titer retroviral vectors for efficient transduction of functional genes into murine hematopoietic stem cells

21 January 2018

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A coiled-coil oligomerization domain of Bcr is essential for the transforming function of Bcr-Abl oncoproteins

21 January 2018

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The NH(2)-terminal coiled-coil domain and tyrosine 177 play important roles in induction of a myeloproliferative disease in mice by Bcr-Abl

21 January 2018

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21 January 2018

Autoinhibition of c-Abl

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Bcr-Abl has a greater intrinsic capacity than v-Abl to induce the neoplastic expansion of myeloid cells

21 January 2018

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Protein modules and signalling networks

21 January 2018

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Differential complementation of Bcr-Abl point mutants with c-Myc

21 January 2018

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Alternative signals to RAS for hematopoietic transformation by the BCR-ABL oncogene

21 January 2018

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The SH2 domain of bcr-Abl is not required to induce a murine myeloproliferative disease; however, SH2 signaling influences disease latency and phenotype

21 January 2018

1 reference

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The src homology 2 domain of Bcr/Abl is required for efficient induction of chronic myeloid leukemia-like disease in mice but not for lymphoid leukemogenesis or activation of phosphatidylinositol 3-kinase

21 January 2018

1 reference

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Expression of interferon consensus sequence binding protein (ICSBP) is downregulated in Bcr-Abl-induced murine chronic myelogenous leukemia-like disease, and forced coexpression of ICSBP inhibits Bcr-Abl-induced myeloproliferative disorder

21 January 2018

1 reference

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BCR-ABL-induced oncogenesis is mediated by direct interaction with the SH2 domain of the GRB-2 adaptor protein

21 January 2018

1 reference

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Oligomerization of the ABL tyrosine kinase by the Ets protein TEL in human leukemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F1042819021000002875

Stat5a and Stat5b proteins have essential and nonessential, or redundant, roles in cytokine responses

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F1042819021000002875

Fetal anemia and apoptosis of red cell progenitors in Stat5a-/-5b-/- mice: a direct role for Stat5 in Bcl-X(L) induction

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F1042819021000002875

Transformation of hematopoietic cells by BCR/ABL requires activation of a PI-3k/Akt-dependent pathway.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F1042819021000002875

Fusion of PDGF receptor beta to a novel ets-like gene, tel, in chronic myelomonocytic leukemia with t(5;12) chromosomal translocation

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F1042819021000002875

Rabaptin-5 is a novel fusion partner to platelet-derived growth factor beta receptor in chronic myelomonocytic leukemia.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F1042819021000002875

The t(8;22) in chronic myeloid leukemia fuses BCR to FGFR1: transforming activity and specific inhibition of FGFR1 fusion proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F1042819021000002875

Point mutations in the FLT3 gene in AML.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F1042819021000002875

Classes of c-KIT activating mutations: proposed mechanisms of action and implications for disease classification and therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F1042819021000002875

Transformation of hematopoietic cell lines to growth-factor independence and induction of a fatal myelo- and lymphoproliferative disease in mice by retrovirally transduced TEL/JAK2 fusion genes

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F1042819021000002875

Signal transduction and transforming properties of the TEL-TRKC fusions associated with t(12;15)(p13;q25) in congenital fibrosarcoma and acute myelogenous leukemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F1042819021000002875

FLT3 internal tandem duplication mutations associated with human acute myeloid leukemias induce myeloproliferative disease in a murine bone marrow transplant model

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F1042819021000002875

Fatal myeloproliferation, induced in mice by TEL/PDGFbetaR expression, depends on PDGFbetaR tyrosines 579/581

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F1042819021000002875

Oncostatin M: signal transduction and biological activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F1042819021000002875

Autocrine production and action of IL-3 and granulocyte colony-stimulating factor in chronic myeloid leukemia.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F1042819021000002875

Interleukin 3 and granulocyte-macrophage colony-stimulating factor are not required for induction of chronic myeloid leukemia-like myeloproliferative disease in mice by BCR/ABL.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F1042819021000002875

Induction of myeloproliferative disease in mice by tyrosine kinase fusion oncogenes does not require granulocyte-macrophage colony-stimulating factor or interleukin-3.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F1042819021000002875

NUP98 gene rearrangements and the clonal evolution of chronic myelogenous leukemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F1042819021000002875

Blast crisis in a murine model of chronic myelogenous leukemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F1042819021000002875

Human AML1/MDS1/EVI1 fusion protein induces an acute myelogenous leukemia (AML) in mice: a model for human AML

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F1042819021000002875

Disruption of the Cbfa2 gene causes necrosis and hemorrhaging in the central nervous system and blocks definitive hematopoiesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F1042819021000002875

Embryonic lethality and impairment of haematopoiesis in mice heterozygous for an AML1-ETO fusion gene.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F1042819021000002875

AML1, the target of multiple chromosomal translocations in human leukemia, is essential for normal fetal liver hematopoiesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F1042819021000002875

Hematopoiesis in the fetal liver is impaired by targeted mutagenesis of a gene encoding a non-DNA binding subunit of the transcription factor, polyomavirus enhancer binding protein 2/core binding factor

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F1042819021000002875

Failure of embryonic hematopoiesis and lethal hemorrhages in mouse embryos heterozygous for a knocked-in leukemia gene CBFB-MYH11.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F1042819021000002875

Cooperation of BCR-ABL and AML1/MDS1/EVI1 in blocking myeloid differentiation and rapid induction of an acute myelogenous leukemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F1042819021000002875

21 January 2018

The Hallmarks of Cancer

1 reference

https://api.crossref.org/works/10.1080%2F1042819021000002875

Integrin-mediated regulation of hematopoiesis: do BCR/ABL-induced defects in integrin function underlie the abnormal circulation and proliferation of CML progenitors?

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F1042819021000002875

Conditional gene targeting

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F1042819021000002875

21 January 2018

BCR-ABL gene variants.

1 reference

https://api.crossref.org/works/10.1080%2F1042819021000002875

Humanbcr-abl gene has a lethal effect on embryogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F1042819021000002875

The fusion of TEL and ABL in human acute lymphoblastic leukaemia is a rare event

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F1042819021000002875

Stat5 is essential for the myelo- and lymphoproliferative disease induced by TEL/JAK2

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F1042819021000002875

Bcr-Abl kinase promotes cell cycle entry of primary myeloid CML cells in the absence of growth factors

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F1042819021000002875

10.1080/1042819021000002875

21 January 2018

Identifiers

DOI

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5 August 2017

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