(Q30164048)

9 June 2017

title

Tyrosine-phosphorylated SOCS3 interacts with the Nck and Crk-L adapter proteins and regulates Nck activation (English)

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9 June 2017

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John C Sitko

1

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9 June 2017

Claudia I Guevara

series ordinal

2

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9 June 2017

Nicholas A Cacalano

series ordinal

3

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9 June 2017

language of work or name

English

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publication date

1 June 2004

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Journal of Biological Chemistry

9 June 2017

published in

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9 June 2017

volume

279

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9 June 2017

issue

36

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9 June 2017

page(s)

37662-37669

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SOCS proteins: negative regulators of cytokine signaling

9 June 2017

cites work

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Twenty proteins containing a C-terminal SOCS box form five structural classes

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The JAK-binding protein JAB inhibits Janus tyrosine kinase activity through binding in the activation loop

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Mutational analyses of the SOCS proteins suggest a dual domain requirement but distinct mechanisms for inhibition of LIF and IL-6 signal transduction

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SOCS-3 is tyrosine phosphorylated in response to interleukin-2 and suppresses STAT5 phosphorylation and lymphocyte proliferation

21 January 2018

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SHP2 and SOCS3 contribute to Tyr-759-dependent attenuation of interleukin-6 signaling through gp130

21 January 2018

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CIS3/SOCS-3 suppresses erythropoietin (EPO) signaling by binding the EPO receptor and JAK2

21 January 2018

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The Elongin BC complex interacts with the conserved SOCS-box motif present in members of the SOCS, ras, WD-40 repeat, and ankyrin repeat families

21 January 2018

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The conserved SOCS box motif in suppressors of cytokine signaling binds to elongins B and C and may couple bound proteins to proteasomal degradation

21 January 2018

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Regulation of Jak2 through the ubiquitin-proteasome pathway involves phosphorylation of Jak2 on Y1007 and interaction with SOCS-1.

21 January 2018

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Socs-1 inhibits TEL-JAK2-mediated transformation of hematopoietic cells through inhibition of JAK2 kinase activity and induction of proteasome-mediated degradation

21 January 2018

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The SOCS box of SOCS-1 accelerates ubiquitin-dependent proteolysis of TEL-JAK2.

21 January 2018

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SOCS-1 and SOCS-3 block insulin signaling by ubiquitin-mediated degradation of IRS1 and IRS2

21 January 2018

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Suppressor of cytokine signaling-1 inhibits VAV function through protein degradation.

21 January 2018

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Negative regulation of FAK signaling by SOCS proteins

21 January 2018

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SOCS1 deficiency causes a lymphocyte-dependent perinatal lethality

21 January 2018

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SOCS1 is a critical inhibitor of interferon gamma signaling and prevents the potentially fatal neonatal actions of this cytokine.

21 January 2018

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Placental defects and embryonic lethality in mice lacking suppressor of cytokine signaling 3

21 January 2018

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SOCS3 is essential in the regulation of fetal liver erythropoiesis

21 January 2018

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SOCS3: an essential regulator of LIF receptor signaling in trophoblast giant cell differentiation

21 January 2018

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Suppressor of cytokine signaling-3 is recruited to the activated granulocyte-colony stimulating factor receptor and modulates its signal transduction

21 January 2018

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SOCS3 is a critical physiological negative regulator of G-CSF signaling and emergency granulopoiesis.

21 January 2018

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SOCS3 is a physiological negative regulator for granulopoiesis and granulocyte colony-stimulating factor receptor signaling.

21 January 2018

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The role of SOCS-3 in leptin signaling and leptin resistance

21 January 2018

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Identification of SOCS-3 as a potential mediator of central leptin resistance

21 January 2018

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The effect of suppressor of cytokine signaling 3 on GH signaling in beta-cells

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M404007200

SOCS-3 inhibits IL-12-induced STAT4 activation by binding through its SH2 domain to the STAT4 docking site in the IL-12 receptor β2 subunit

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M404007200

SOCS-3 regulates onset and maintenance of T(H)2-mediated allergic responses

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M404007200

Tyrosine-phosphorylated SOCS-3 inhibits STAT activation but binds to p120 RasGAP and activates Ras

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M404007200

Autosomal SCID caused by a point mutation in the N-terminus of Jak3: mapping of the Jak3-receptor interaction domain

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M404007200

Tyrosine phosphorylation disrupts elongin interaction and accelerates SOCS3 degradation

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M404007200

SH2 domains recognize specific phosphopeptide sequences

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M404007200

The Nck SH2/SH3 adaptor protein: a regulator of multiple intracellular signal transduction events

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M404007200

Physiological signals and oncogenesis mediated through Crk family adapter proteins

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M404007200

Crk family adaptors-signalling complex formation and biological roles

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M404007200

Nck/Dock: an adapter between cell surface receptors and the actin cytoskeleton

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M404007200

Differential inhibition of signaling pathways by dominant-negative SH2/SH3 adapter proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M404007200

IL-6 induces an anti-inflammatory response in the absence of SOCS3 in macrophages

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M404007200

Two signaling molecules share a phosphotyrosine-containing binding site in the platelet-derived growth factor receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M404007200

Phosphorylation of Nck in response to a variety of receptors, phorbol myristate acetate, and cyclic AMP

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M404007200

The SH2 and SH3 domain-containing Nck protein is oncogenic and a common target for phosphorylation by different surface receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M404007200

Vascular endothelial cell growth factor promotes tyrosine phosphorylation of mediators of signal transduction that contain SH2 domains. Association with endothelial cell proliferation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M404007200

Induced direct binding of the adapter protein Nck to the GTPase-activating protein-associated protein p62 by epidermal growth factor

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M404007200

The Tek/Tie2 receptor signals through a novel Dok-related docking protein, Dok-R

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M404007200

Independent SH2-binding sites mediate interaction of Dok-related protein with RasGTPase-activating protein and Nck

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M404007200

Nck-interacting Ste20 kinase couples Eph receptors to c-Jun N-terminal kinase and integrin activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M404007200

Juxtamembrane tyrosine residues couple the Eph family receptor EphB2/Nuk to specific SH2 domain proteins in neuronal cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M404007200

Insulin receptor-mediated p62dok tyrosine phosphorylation at residues 362 and 398 plays distinct roles for binding GTPase-activating protein and Nck and is essential for inhibiting insulin-stimulated activation of Ras and Akt.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M404007200

Dok protein family members are involved in signaling mediated by the type 1 Fcepsilon receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M404007200

Tyrosine phosphorylation of Cbl upon epidermal growth factor (EGF) stimulation and its association with EGF receptor and downstream signaling proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M404007200

Identification of the Abl- and rasGAP-associated 62 kDa protein as a docking protein, Dok

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M404007200

T cell regulation of p62(dok) (Dok1) association with Crk-L

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M404007200

The murine Nck SH2/SH3 adaptors are important for the development of mesoderm-derived embryonic structures and for regulating the cellular actin network

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M404007200

Mice lacking the homologue of the human 22q11.2 gene CRKL phenocopy neurocristopathies of DiGeorge syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M404007200

Nckβ Interacts with Tyrosine-Phosphorylated Disabled 1 and Redistributes in Reelin-Stimulated Neurons

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M404007200

Nckbeta adapter regulates actin polymerization in NIH 3T3 fibroblasts in response to platelet-derived growth factor bb

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M404007200

The adaptor protein Nck links receptor tyrosine kinases with the serine-threonine kinase Pak1

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M404007200

Interaction of the Nck adapter protein with p21-activated kinase (PAK1)

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M404007200

Activation of Pak by membrane localization mediated by an SH3 domain from the adaptor protein Nck.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M404007200

Isolation of a NCK-associated kinase, PRK2, an SH3-binding protein and potential effector of Rho protein signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M404007200

NIK is a new Ste20-related kinase that binds NCK and MEKK1 and activates the SAPK/JNK cascade via a conserved regulatory domain

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M404007200

Wiskott-Aldrich syndrome protein physically associates with Nck through Src homology 3 domains

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M404007200

Wiskott-Aldrich syndrome protein is associated with the adapter protein Grb2 and the epidermal growth factor receptor in living cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M404007200

Cdc42 and PAK-mediated signaling leads to Jun kinase and p38 mitogen-activated protein kinase activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M404007200

Novel function of Chat in controlling cell adhesion via Cas-Crk-C3G-pathway-mediated Rap1 activation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M404007200

Interaction between the amino-terminal SH3 domain of CRK and its natural target proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M404007200

CrkL mediates Ras-dependent activation of the Raf/ERK pathway through the guanine nucleotide exchange factor C3G in hematopoietic cells stimulated with erythropoietin or interleukin-3.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M404007200

Interaction of hematopoietic progenitor kinase 1 with adapter proteins Crk and CrkL leads to synergistic activation of c-Jun N-terminal kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M404007200

Guanine-nucleotide exchange protein C3G activates JNK1 by a ras-independent mechanism. JNK1 activation inhibited by kinase negative forms of MLK3 and DLK mixed lineage kinases

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M404007200

Crk activation of JNK via C3G and R-Ras

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M404007200

STAT3-mediated constitutive expression of SOCS-3 in cutaneous T-cell lymphoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M404007200

Identification of the mechanisms regulating the differential activation of the mapk cascade by epidermal growth factor and nerve growth factor in PC12 cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M404007200

Grit, a GTPase-activating protein for the Rho family, regulates neurite extension through association with the TrkA receptor and N-Shc and CrkL/Crk adapter molecules

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M404007200

The adaptor protein Crk connects multiple cellular stimuli to the JNK signaling pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M404007200

The SH2- and SH3-containing Nck protein transforms mammalian fibroblasts in the absence of elevated phosphotyrosine levels

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M404007200

Role of the adapter protein CRKL in signal transduction of normal hematopoietic and BCR/ABL-transformed cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M404007200

Smenospongine, a spongean sesquiterpene aminoquinone, induces erythroid differentiation in K562 cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M404007200

Cell-penetrating SH3 domain blocker peptides inhibit proliferation of primary blast cells from CML patients

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M404007200

Constitutive expression of SOCS3 confers resistance to IFN-alpha in chronic myelogenous leukemia cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M404007200

Enhancement of guanine-nucleotide exchange activity of C3G for Rap1 by the expression of Crk, CrkL, and Grb2

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M404007200

21 January 2018

Identifiers

DOI

10.1074/JBC.M404007200

1 reference

release_sjyq43qr5bewpk4r2qwrlktjpe

9 June 2017

Fatcat ID

1 reference

Fatcat

https://api.fatcat.wiki/v0/release/sjyq43qr5bewpk4r2qwrlktjpe

mapped directly with Wikidata item

24 November 2022

based on heuristic

1 reference