(Q30168090)

English

T cell activation induces direct binding of the Crk adapter protein to the regulatory subunit of phosphatidylinositol 3-kinase (p85) via a complex mechanism involving the Cbl protein

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scholarly article

1 reference

Europe PubMed Central

PubMed publication ID

9 June 2017

T cell activation induces direct binding of the Crk adapter protein to the regulatory subunit of phosphatidylinositol 3-kinase (p85) via a complex mechanism involving the Cbl protein (English)

1 reference

Europe PubMed Central

PubMed publication ID

9 June 2017

T cell activation

1 reference

based on heuristic

inferred from title

author name string

S Gelkop

1

1 reference

Europe PubMed Central

PubMed publication ID

9 June 2017

Y Babichev

2

1 reference

Europe PubMed Central

PubMed publication ID

9 June 2017

N Isakov

3

1 reference

Europe PubMed Central

PubMed publication ID

9 June 2017

language of work or name

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publication date

20 June 2001

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Europe PubMed Central

PubMed publication ID

9 June 2017

number of pages

9

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based on heuristic

inferred from page(s)

Journal of Biological Chemistry

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Europe PubMed Central

PubMed publication ID

9 June 2017

276

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Europe PubMed Central

PubMed publication ID

9 June 2017

39

1 reference

Europe PubMed Central

PubMed publication ID

9 June 2017

36174-36182

1 reference

Europe PubMed Central

PubMed publication ID

9 June 2017

T cell antigen receptor signal transduction

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Aggregation of lipid rafts accompanies signaling via the T cell antigen receptor

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Three-dimensional segregation of supramolecular activation clusters in T cells

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Adaptors and molecular scaffolds in immune cell signaling

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Interleukin-2 stimulation induces tyrosine phosphorylation of p120-Cbl and CrkL and formation of multimolecular signaling complexes in T lymphocytes and natural killer cells

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CAS/Crk coupling serves as a "molecular switch" for induction of cell migration

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Both the SH2 and SH3 domains of human CRK protein are required for neuronal differentiation of PC12 cells

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CrkII signals from epidermal growth factor receptor to Ras

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Integration of T cell receptor-dependent signaling pathways by adapter proteins

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Cbl-mediated regulation of T cell receptor-induced AP1 activation. Implications for activation via the Ras signaling pathway

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The Cbl protooncoprotein: a negative regulator of immune receptor signal transduction

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Tissue hyperplasia and enhanced T-cell signalling via ZAP-70 in c-Cbl-deficient mice

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Activation of nuclear factor of activated T cells-(NFAT) and activating protein 1 (AP-1) by oncogenic 70Z Cbl requires an intact phosphotyrosine binding domain but not Crk(L) or p85 phosphatidylinositol 3-kinase association

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Dual regulation of T cell receptor-mediated signaling by oncogenic Cbl mutant 70Z.

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Cbl: complex formation and functional implications

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Interactions of Cbl with two adapter proteins, Grb2 and Crk, upon T cell activation

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Interactions of Cbl with Grb2 and phosphatidylinositol 3'-kinase in activated Jurkat cells

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A ras-related gene with transformation suppressor activity

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Complexes of Ras.GTP with Raf-1 and mitogen-activated protein kinase kinase

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T cell activation stimulates the association of enzymatically active tyrosine-phosphorylated ZAP-70 with the Crk adapter proteins

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Insulin-like growth factor-I stimulates tyrosine phosphorylation of endogenous c-Crk

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Crk protein binds to PDGF receptor and insulin receptor substrate-1 with different modulating effects on PDGF- and insulin-dependent signaling pathways

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SH2 and SH3 domains as molecular adhesives: the interactions of Crk and Abl

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Direct demonstration of an intramolecular SH2-phosphotyrosine interaction in the Crk protein

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Phosphorylation of CrkII adaptor protein at tyrosine 221 by epidermal growth factor receptor

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Tyrosine phosphorylation of Cbl upon epidermal growth factor (EGF) stimulation and its association with EGF receptor and downstream signaling proteins

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CSF-1 stimulation induces the formation of a multiprotein complex including CSF-1 receptor, c-Cbl, PI 3-kinase, Crk-II and Grb2

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Steel factor induces tyrosine phosphorylation of CRKL and binding of CRKL to a complex containing c-kit, phosphatidylinositol 3-kinase, and p120(CBL)

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SH2 domains recognize specific phosphopeptide sequences

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Ras-dependent, Ca2+-stimulated activation of nuclear factor of activated T cells by a constitutively active Cbl mutant in T cells.

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Fyn associates with Cbl and phosphorylates tyrosine 731 in Cbl, a binding site for phosphatidylinositol 3-kinase

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Solution structure and ligand-binding site of the SH3 domain of the p85 alpha subunit of phosphatidylinositol 3-kinase

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Distinct ligand preferences of Src homology 3 domains from Src, Yes, Abl, Cortactin, p53bp2, PLCgamma, Crk, and Grb2.

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Interaction between the amino-terminal SH3 domain of CRK and its natural target proteins

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Specific association of the beta isoform of the p85 subunit of phosphatidylinositol-3 kinase with the proto-oncogene c-cbl

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A potential SH3 domain-binding site in the Crk SH2 domain

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The RING Finger Domain of Cbl Is Essential for Negative Regulation of the Syk Tyrosine Kinase

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Stimulation through the T cell receptor induces Cbl association with Crk proteins and the guanine nucleotide exchange protein C3G

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Blocked Signal Transduction to the ERK and JNK Protein Kinases in Anergic CD4+ T Cells

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Blocked Ras activation in anergic CD4+ T cells

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A negative role for phosphoinositide 3-kinase in T-cell antigen receptor function

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Purification and characterization of human ZAP-70 protein-tyrosine kinase from a baculovirus expression system

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Identifiers

10.1074/JBC.M100731200

1 reference

Europe PubMed Central

PubMed publication ID

9 June 2017

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

9 June 2017

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