(Q30300318)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25802278%20AND%20SRC:MED&resulttype=core&format=json

3 March 2020

title

Wnt-Lrp5 signaling regulates fatty acid metabolism in the osteoblast (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25802278%20AND%20SRC:MED&resulttype=core&format=json

3 March 2020

0 references

0 references

5

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25802278%20AND%20SRC:MED&resulttype=core&format=json

3 March 2020

Michael Wolfgang

7

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25802278%20AND%20SRC:MED&resulttype=core&format=json

3 March 2020

author name string

Julie L Frey

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25802278%20AND%20SRC:MED&resulttype=core&format=json

3 March 2020

Zhu Li

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25802278%20AND%20SRC:MED&resulttype=core&format=json

3 March 2020

Jessica M Ellis

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25802278%20AND%20SRC:MED&resulttype=core&format=json

3 March 2020

Qian Zhang

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25802278%20AND%20SRC:MED&resulttype=core&format=json

3 March 2020

Susan Aja

6

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25802278%20AND%20SRC:MED&resulttype=core&format=json

3 March 2020

Thomas L Clemens

8

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25802278%20AND%20SRC:MED&resulttype=core&format=json

3 March 2020

Ryan C Riddle

9

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25802278%20AND%20SRC:MED&resulttype=core&format=json

3 March 2020

language of work or name

English

0 references

publication date

23 March 2015

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25802278%20AND%20SRC:MED&resulttype=core&format=json

Molecular and Cellular Biology

3 March 2020

published in

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25802278%20AND%20SRC:MED&resulttype=core&format=json

3 March 2020

volume

35

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25802278%20AND%20SRC:MED&resulttype=core&format=json

3 March 2020

issue

11

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25802278%20AND%20SRC:MED&resulttype=core&format=json

3 March 2020

page(s)

1979-1991

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25802278%20AND%20SRC:MED&resulttype=core&format=json

describes a project that uses

3 March 2020

limma

1 reference

22 June 2022

https://europepmc.org/article/PMC/4420919

inferred from PubMed Central ID database lookup

cites work

The combined hyperlipidemia caused by impaired Wnt-LRP6 signaling is reversed by Wnt3a rescue

1 reference

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Lrp5 and Lrp6 exert overlapping functions in osteoblasts during postnatal bone acquisition

3 June 2018

1 reference

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WNT-LRP5 signaling induces Warburg effect through mTORC2 activation during osteoblast differentiation.

3 June 2018

1 reference

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Acyl coenzyme A thioesterase 7 regulates neuronal fatty acid metabolism to prevent neurotoxicity

3 June 2018

1 reference

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Central activating transcription factor 4 (ATF4) regulates hepatic insulin resistance in mice via S6K1 signaling and the vagus nerve

3 June 2018

1 reference

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Diabetes risk gene and Wnt effector Tcf7l2/TCF4 controls hepatic response to perinatal and adult metabolic demand

3 June 2018

1 reference

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Wnt signaling in bone development and disease: making stronger bone with Wnts

3 June 2018

1 reference

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The skeleton as an endocrine organ

3 June 2018

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Wntless functions in mature osteoblasts to regulate bone mass

3 June 2018

1 reference

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Loss of wnt/β-catenin signaling causes cell fate shift of preosteoblasts from osteoblasts to adipocytes

3 June 2018

1 reference

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Mechanisms for insulin resistance: common threads and missing links

3 June 2018

1 reference

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Cross-talk between insulin and Wnt signaling in preadipocytes: role of Wnt co-receptor low density lipoprotein receptor-related protein-5 (LRP5).

3 June 2018

1 reference

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The contribution of bone to whole-organism physiology

3 June 2018

1 reference

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LRP6 protein regulates low density lipoprotein (LDL) receptor-mediated LDL uptake

3 June 2018

1 reference

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Biology without walls: the novel endocrinology of bone.

3 June 2018

1 reference

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Sclerostin and its association with physical activity, age, gender, body composition, and bone mineral content in healthy adults

3 June 2018

1 reference

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Lrp5 and Lrp6 redundantly control skeletal development in the mouse embryo

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4420919

Dissecting molecular differences between Wnt coreceptors LRP5 and LRP6

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4420919

Wnt6, Wnt10a and Wnt10b inhibit adipogenesis and stimulate osteoblastogenesis through a β-catenin-dependent mechanism.

3 June 2018

1 reference

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Lrp5 functions in bone to regulate bone mass

3 June 2018

1 reference

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Genetic evidence points to an osteocalcin-independent influence of osteoblasts on energy metabolism

3 June 2018

1 reference

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Intermittent injections of osteocalcin improve glucose metabolism and prevent type 2 diabetes in mice

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4420919

Leucine deprivation increases hepatic insulin sensitivity via GCN2/mTOR/S6K1 and AMPK pathways

3 June 2018

1 reference

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Insulin receptor signaling in osteoblasts regulates postnatal bone acquisition and body composition

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4420919

Insulin signaling in osteoblasts integrates bone remodeling and energy metabolism

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4420919

Guidelines for assessment of bone microstructure in rodents using micro-computed tomography

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4420919

Wnt/beta-catenin signaling: components, mechanisms, and diseases

3 June 2018

1 reference

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Association between TCF7L2 gene polymorphisms and susceptibility to type 2 diabetes mellitus: a large Human Genome Epidemiology (HuGE) review and meta-analysis

3 June 2018

1 reference

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Lrp5 controls bone formation by inhibiting serotonin synthesis in the duodenum

3 June 2018

1 reference

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Mutation in EGFP domain of LDL receptor-related protein 6 impairs cellular LDL clearance

3 June 2018

1 reference

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LRP5 in premature adrenarche and in metabolic characteristics of prepubertal children

3 June 2018

1 reference

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lumi: a pipeline for processing Illumina microarray

3 June 2018

1 reference

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Osteocalcin differentially regulates beta cell and adipocyte gene expression and affects the development of metabolic diseases in wild-type mice

3 June 2018

1 reference

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Model-based variance-stabilizing transformation for Illumina microarray data.

3 June 2018

1 reference

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Endocrine regulation of energy metabolism by the skeleton

3 June 2018

1 reference

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LRP6 mutation in a family with early coronary disease and metabolic risk factors

3 June 2018

1 reference

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Increased pancreatic beta-cell proliferation mediated by CREB binding protein gene activation

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4420919

Polymorphisms of the low-density lipoprotein receptor-related protein 5 (LRP5) gene are associated with obesity phenotypes in a large family-based association study

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4420919

Linear models and empirical bayes methods for assessing differential expression in microarray experiments

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4420919

Variant of transcription factor 7-like 2 (TCF7L2) gene confers risk of type 2 diabetes

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4420919

A prospective study of changes in bone turnover and bone density associated with regaining weight in women with anorexia nervosa

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4420919

SOST is a ligand for LRP5/LRP6 and a Wnt signaling inhibitor

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4420919

Canonical Wnt signaling in differentiated osteoblasts controls osteoclast differentiation

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4420919

Canonical Wnt/beta-catenin signaling prevents osteoblasts from differentiating into chondrocytes

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4420919

Essential role of beta-catenin in postnatal bone acquisition

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4420919

The Wnt co-receptors Lrp5 and Lrp6 are essential for gastrulation in mice

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4420919

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4420919

High bone mass in mice expressing a mutant LRP5 gene

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4420919

Low-density lipoprotein receptor-related protein 5 (LRP5) is essential for normal cholesterol metabolism and glucose-induced insulin secretion

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4420919

A novel set of Wnt-Frizzled fusion proteins identifies receptor components that activate beta -catenin-dependent signaling

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4420919

High bone density due to a mutation in LDL-receptor-related protein 5

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4420919

A mutation in the LDL receptor-related protein 5 gene results in the autosomal dominant high-bone-mass trait

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4420919

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4420919

The sequence and gene characterization of a 400-kb candidate region for IDDM4 on chromosome 11q13

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4420919

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4420919

Inhibition of adipogenesis by Wnt signaling

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4420919

Apolipoprotein E (ApoE), a Bmp-2 (bone morphogenetic protein) upregulated gene in mesenchymal progenitors (C3H10T1/2), is highly expressed in murine embryonic development

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4420919

Molecular cloning of mouse Lrp7(Lr3) cDNA and chromosomal mapping of orthologous genes in mouse and human

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4420919

Cloning of a novel member of the low-density lipoprotein receptor family

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4420919

Isolation and characterization of LRP6, a novel member of the low density lipoprotein receptor gene family

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4420919

Short stature in anorexia nervosa patients

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4420919

Aerobic glycolysis in bone: lactic acid production by rat calvaria cells in culture

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4420919

Association of circulating sclerostin levels with fat mass and metabolic disease--related markers in Japanese postmenopausal women

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4420919

The osteoblast: an insulin target cell controlling glucose homeostasis.

26 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4420919

Sclerostin antibody increases bone mass by stimulating bone formation and inhibiting bone resorption in a hindlimb-immobilization rat model

26 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4420919

TCF7L2 is associated with high serum triacylglycerol and differentially expressed in adipose tissue in families with familial combined hyperlipidaemia.

26 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4420919

Low-density lipoprotein receptor-related protein 5 variant Q89R is associated with hypertension in Japanese females.

26 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4420919

Severe hypercholesterolemia, impaired fat tolerance, and advanced atherosclerosis in mice lacking both low density lipoprotein receptor-related protein 5 and apolipoprotein E.

26 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4420919

A new low density lipoprotein receptor related protein, LRP5, is expressed in hepatocytes and adrenal cortex, and recognizes apolipoprotein E.

26 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4420919

Activation of the Wnt signaling pathway: a molecular mechanism for lithium action

26 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4420919

Fatty acid oxidation in bone tissue and bone cells in culture. Characterization and hormonal influences

26 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4420919

Inhibition of sclerostin by monoclonal antibody enhances bone healing and improves bone density and strength of nonfractured bones

26 November 2018

1 reference

12 December 2020

Insulin-like growth factors stimulate synthesis of nucleic acids and glycogen in cultured calvaria cells

1 reference

12 December 2020

Use of a selective inhibitor of liver carnitine palmitoyltransferase I (CPT I) allows quantification of its contribution to total CPT I activity in rat heart. Evidence that the dominant cardiac CPT I isoform is identical to the skeletal muscle enzym

1 reference

12 December 2020

Parathormone promotes glycogen formation from [14C]glucose in cultured osteoblast-like cells

1 reference

12 December 2020

Circulating Levels of Sclerostin Are Increased in Patients with Type 2 Diabetes Mellitus

1 reference

12 December 2020

Uptake of postprandial lipoproteins into bone in vivo: impact on osteoblast function

1 reference

12 December 2020

Osteoblast-specific knockout of the insulin-like growth factor (IGF) receptor gene reveals an essential role of IGF signaling in bone matrix mineralization

1 reference

12 December 2020

Growth of rat osteoblast-like cells in a lipid-enriched culture medium and regulation of function by parathyroid hormone and 1,25-dihydroxyvitamin D

1 reference

12 December 2020

G-protein beta 3 subunit polymorphism C1429T and low-density lipoprotein receptor-related protein 5 polymorphism A1330V are risk factors for hypercholesterolemia in Japanese males--a prospective study over 5 years

1 reference

12 December 2020

Identifiers

DOI

10.1128/MCB.01343-14

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25802278%20AND%20SRC:MED&resulttype=core&format=json

3 March 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25802278%20AND%20SRC:MED&resulttype=core&format=json

3 March 2020

PubMed publication ID

25802278

1 reference