(Q30327666)

18 June 2017

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title

Protein instability in poly(lactic-co-glycolic acid) microparticles. (English)

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18 June 2017

van de Weert M

1

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18 June 2017

Hennink WE

series ordinal

2

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18 June 2017

Jiskoot W

series ordinal

3

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18 June 2017

publication date

1 October 2000

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18 June 2017

published in

Pharmaceutical Research

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18 June 2017

volume

17

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18 June 2017

issue

10

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18 June 2017

page(s)

1159-1167

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Quality improvement of spray-dried, protein-loaded D,L-PLA microspheres by appropriate polymer solvent selection

18 June 2017

cites work

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12 December 2020

A new strategy to determine the actual protein content of poly(lactide-co-glycolide) microspheres

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12 December 2020

Preparation and characterization of protein C-loaded PLA nanoparticles

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12 December 2020

Microencapsulation of hepatitis B core antigen for vaccine preparation

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12 December 2020

Solvent evaporation processes for the production of controlled release biodegradable microsphere formulations for therapeutics and vaccines

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A month-long effect from a single injection of microencapsulated human growth hormone

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Development and scale-up of a microsphere protein delivery system

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12 December 2020

Technique to control pH in vicinity of biodegrading PLA-PGA implants

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12 December 2020

Solid-phase aggregation of proteins under pharmaceutically relevant conditions

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12 December 2020

pH and osmotic pressure inside biodegradable microspheres during erosion

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12 December 2020

FTIR characterization of the secondary structure of proteins encapsulated within PLGA microspheres

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12 December 2020

Physico-chemical and antigenic properties of tetanus and diphtheria toxoids and steps towards improved stability

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12 December 2020

Protein behavior at the water/methylene chloride interface

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12 December 2020

The development of stable protein formulations: a close look at protein aggregation, deamidation, and oxidation.

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12 December 2020

Factors affecting the in vitro release of recombinant human interferon-gamma (rhIFN-gamma) from PLGA microspheres

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12 December 2020

Characterization of poly(glycolide-co-D,L-lactide)/poly(D,L-lactide) microspheres for controlled release of GM-CSF

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12 December 2020

The stability of recombinant human growth hormone in poly(lactic-co-glycolic acid) (PLGA) microspheres

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12 December 2020

On the structural preservation of recombinant human growth hormone in a dried film of a synthetic biodegradable polymer

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12 December 2020

Structure of lysozyme dissolved in neat organic solvents as assessed by NMR and CD spectroscopies

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12 December 2020

Microencapsulation of human growth hormone within biodegradable polyester microspheres: protein aggregation stability and incomplete release mechanism

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12 December 2020

Improving stability and release kinetics of microencapsulated tetanus toxoid by co-encapsulation of additives

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12 December 2020

Formulation strategies for the stabilization of tetanus toxoid in poly(lactide-co-glycolide) microspheres.

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12 December 2020

Strategies for stabilising tetanus toxoid towards the development of a single-dose tetanus vaccine.

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12 December 2020

New strategies for the microencapsulation of tetanus vaccine.

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12 December 2020

Porcine insulin biodegradable polyester microspheres: stability and in vitro release characteristics

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12 December 2020

The stabilization and encapsulation of human growth hormone into biodegradable microspheres

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12 December 2020

Why does PEG 400 co-encapsulation improve NGF stability and release from PLGA biodegradable microspheres?

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12 December 2020

Protein delivery from poly(lactic-co-glycolic acid) biodegradable microspheres: release kinetics and stability issues

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12 December 2020

Stabilization of pH-induced degradation of porcine insulin in biodegradable polyester microspheres

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12 December 2020

Influence of formulation variables on the in-vitro release of albumin from biodegradable microparticulate systems

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12 December 2020

Erythropoietin loaded microspheres prepared from biodegradable LPLG-PEO-LPLG triblock copolymers: protein stabilization and in-vitro release properties.

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12 December 2020

Physicochemical and immunological studies on the stability of free and microsphere-encapsulated tetanus toxoid in vitro

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12 December 2020

Solid-state chemical stability of proteins and peptides

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12 December 2020

Improved immunogenicity of a core-coated tetanus toxoid delivery system

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12 December 2020

Can conformational changes be responsible for solvent and excipient effects on the catalytic behavior of subtilisin Carlsberg in organic solvents?

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12 December 2020

Adsorption of serum albumin to thin films of poly(lactide-co-glycolide).

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12 December 2020

Diphtheria and tetanus toxoid microencapsulation into conventional and end-group alkylated PLA/PLGAs

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12 December 2020

Instability, stabilization, and formulation of liquid protein pharmaceuticals

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12 December 2020

Biodegradable microspheres as controlled-release tetanus toxoid delivery systems.

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12 December 2020

Preparation of non-porous microspheres with high entrapment efficiency of proteins by a (water-in-oil)-in-oil emulsion technique

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12 December 2020

Ultrasonic atomization for spray drying: a versatile technique for the preparation of protein loaded biodegradable microspheres

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12 December 2020

Rational design of stable lyophilized protein formulations: some practical advice

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12 December 2020

The acidic microclimate in poly(lactide-co-glycolide) microspheres stabilizes camptothecins

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12 December 2020

Chemical interactions between drugs containing reactive amines with hydrolyzable insoluble biopolymers in aqueous solutions.

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12 December 2020

Protein release from poly(lactic-co-glycolic acid) microspheres: protein stability problems

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12 December 2020

Recombinant human erythropoietin (rhEPO) loaded poly(lactide-co-glycolide) microspheres: influence of the encapsulation technique and polymer purity on microsphere characteristics

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12 December 2020

Free radical formation induced by ultrasound and its biological implications

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12 December 2020

Protein instability toward organic solvent/water emulsification: implications for protein microencapsulation into microspheres

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12 December 2020

Use of infrared spectroscopy to assess secondary structure of human growth hormone within biodegradable microspheres

1 reference

12 December 2020

Stable formulations of recombinant human growth hormone and interferon-gamma for microencapsulation in biodegradable microspheres

1 reference

12 December 2020

Formulation of L-asparaginase-loaded poly(lactide-co-glycolide) nanoparticles: influence of polymer properties on enzyme loading, activity and in vitro release

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12 December 2020

The distribution of protein associated with poly(DL-lactide co-glycolide) microparticles and its degradation in simulated body fluids

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12 December 2020

Lysozyme distribution and conformation in a biodegradable polymer matrix as determined by FTIR techniques

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12 December 2020

Stabilization of proteins against methylene chloride/water interface-induced denaturation and aggregation

1 reference

12 December 2020

Release of human serum albumin from poly(lactide-co-glycolide) microspheres

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12 December 2020

Stabilization of proteins encapsulated in injectable poly (lactide- co-glycolide)

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12 December 2020

A new preparation method for protein loaded poly(D, L-lactic-co-glycolic acid) microspheres and protein release mechanism study

1 reference

12 December 2020

Monitoring microviscosity and microacidity of the albumin microenvironment inside degrading microparticles from poly(lactide-co-glycolide) (PLG) or ABA-triblock polymers containing hydrophobic poly(lactide-co-glycolide) A blocks and hydrophilic poly

1 reference

12 December 2020

Encapsulation of lysozyme in a biodegradable polymer by precipitation with a vapor-over-liquid antisolvent

1 reference

12 December 2020

Biodegradable Polymers for Protein and Peptide Drug Delivery

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12 December 2020

NGF release from poly(D,L-lactide-co-glycolide) microspheres. Effect of some formulation parameters on encapsulated NGF stability

1 reference

12 December 2020

Identifiers

DOI

10.1023/A:1026498209874

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18 June 2017

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