(Q33608756)

28 July 2017

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title

Solid-state chemical stability of proteins and peptides (English)

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28 July 2017

Lai MC

1

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28 July 2017

Topp EM

series ordinal

2

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28 July 2017

language of work or name

English

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publication date

1 May 1999

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Journal of Pharmaceutical Sciences

28 July 2017

published in

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28 July 2017

volume

88

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28 July 2017

issue

5

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28 July 2017

page(s)

489-500

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Stability of protein pharmaceuticals

28 July 2017

cites work

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7 January 2021

Rational design of stable lyophilized protein formulations: some practical advice

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7 January 2021

The effects of formulation variables on the stability of freeze-dried human growth hormone

1 reference

7 January 2021

An unexpected pH effect on the stability of moexipril lyophilized powder

1 reference

7 January 2021

Chemical pathways of peptide degradation. I. Deamidation of adrenocorticotropic hormone

1 reference

7 January 2021

Solid-phase aggregation of proteins under pharmaceutically relevant conditions

1 reference

7 January 2021

Development of a stable freeze-dried formulation of recombinant human interleukin-1 receptor antagonist

1 reference

7 January 2021

Solid-state stability of human insulin. I. Mechanism and the effect of water on the kinetics of degradation in lyophiles from pH 2-5 solutions

1 reference

7 January 2021

The stability of insulin in crystalline and amorphous solids: observation of greater stability for the amorphous form

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7 January 2021

Chemical pathways of peptide degradation. II. Kinetics of deamidation of an asparaginyl residue in a model hexapeptide

1 reference

7 January 2021

Chemical pathways of peptide degradation. III. Effect of primary sequence on the pathways of deamidation of asparaginyl residues in hexapeptides

1 reference

7 January 2021

Isolation and identification of peptide degradation products of heat stressed pramlintide injection drug product

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7 January 2021

Chemical pathways of peptide degradation. VII. Solid state chemical instability of an aspartyl residue in a model hexapeptide

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7 January 2021

Chemical pathways of peptide degradation. IV. Pathways, kinetics, and mechanism of degradation of an aspartyl residue in a model hexapeptide

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7 January 2021

Effects of reducing sugars on the chemical stability of human relaxin in the lyophilized state

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7 January 2021

Solid state stability studies of model dipeptides: aspartame and aspartylphenylalanine

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7 January 2021

Spontaneous chemical degradation of substance P in the solid phase and in solution

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7 January 2021

Oxidation of human insulin-like growth factor I in formulation studies: kinetics of methionine oxidation in aqueous solution and in solid state

1 reference

7 January 2021

Characterization of a solid state reaction product from a lyophilized formulation of a cyclic heptapeptide. A novel example of an excipient-induced oxidation

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7 January 2021

Moisture-induced aggregation of lyophilized insulin

1 reference

7 January 2021

Moisture-induced aggregation of lyophilized proteins in the solid state

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7 January 2021

The aggregation of bovine serum albumin in solution and in the solid state

1 reference

7 January 2021

Aggregation pathway of recombinant human keratinocyte growth factor and its stabilization

1 reference

7 January 2021

Aggregation of a lyophilized pharmaceutical protein, recombinant human albumin: effect of moisture and stabilization by excipients

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7 January 2021

Lyophilized formulations of recombinant tumor necrosis factor

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7 January 2021

The effects of formulation additives on the degradation of freeze-dried ribonuclease A.

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7 January 2021

Nature of aggregates formed during storage of freeze-dried ribonuclease A

1 reference

7 January 2021

Stabilization of tetanus and diphtheria toxoids against moisture-induced aggregation

1 reference

7 January 2021

The reaction between proteins and reducing sugars in the 'dry' state; relative reactivity of the alpha- and epsilon-amino groups of insulin

1 reference

7 January 2021

How does residual water affect the solid-state degradation of drugs in the amorphous state?

1 reference

7 January 2021

Solid-state stability of human insulin. II. Effect of water on reactive intermediate partitioning in lyophiles from pH 2-5 solutions: stabilization against covalent dimer formation

1 reference

7 January 2021

Bond cleavage reactions in solid aqueous carbohydrate solutions

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7 January 2021

The stability of recombinant human growth hormone in poly(lactic-co-glycolic acid) (PLGA) microspheres

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7 January 2021

The stabilization and encapsulation of human growth hormone into biodegradable microspheres

1 reference

7 January 2021

Improving protein therapeutics with sustained-release formulations

1 reference

7 January 2021

Dependence of the molecular mobility and protein stability of freeze-dried gamma-globulin formulations on the molecular weight of dextran

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7 January 2021

Controlled release of polypeptides from polyanhydrides

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7 January 2021

Stability of ribonuclease A in solution and the freeze-dried state

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7 January 2021

Chemical stability of indomethacin in the solid amorphous and molten states

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7 January 2021

Physical factors affecting the storage stability of freeze-dried interleukin-1 receptor antagonist: glass transition and protein conformation

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7 January 2021

Molecular mobility of amorphous pharmaceutical solids below their glass transition temperatures

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7 January 2021

Molecular mobility in mixtures of absorbed water and solid poly(vinylpyrrolidone).

1 reference

7 January 2021

The effect of excipients on the molecular mobility of lyophilized formulations, as measured by glass transition temperature and NMR relaxation-based critical mobility temperature

1 reference

7 January 2021

Effect of high molecular mobility of poly(vinyl alcohol) on protein stability of lyophilized gamma-globulin formulations

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7 January 2021

Secondary structure and protein deamidation

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7 January 2021

Use of infrared spectroscopy to assess secondary structure of human growth hormone within biodegradable microspheres

1 reference

7 January 2021

Identifiers

DOI

10.1021/JS980374E

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28 July 2017

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