(Q73426644)

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Solid-state stability of human insulin. II. Effect of water on reactive intermediate partitioning in lyophiles from pH 2-5 solutions: stabilization against covalent dimer formation

scientific article published on 01 June 1997

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scholarly article

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9188045%20AND%20SRC:MED&resulttype=core&format=json

3 November 2019

Solid-state stability of human insulin. II. Effect of water on reactive intermediate partitioning in lyophiles from pH 2-5 solutions: stabilization against covalent dimer formation (English)

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3 November 2019

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Strickley RG

1

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3 November 2019

Anderson BD

2

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3 November 2019

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1 June 1997

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3 November 2019

Journal of Pharmaceutical Sciences

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9188045%20AND%20SRC:MED&resulttype=core&format=json

3 November 2019

86

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3 November 2019

6

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3 November 2019

645-653

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3 November 2019

The role of intramolecular nucleophilic catalysis and the effects of self-association on the deamidation of human insulin at low pH

1 reference

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Chemical pathways of peptide degradation. I. Deamidation of adrenocorticotropic hormone

1 reference

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Chemical pathways of peptide degradation. IV. Pathways, kinetics, and mechanism of degradation of an aspartyl residue in a model hexapeptide

1 reference

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Role of peptide conformation in the rate and mechanism of deamidation of asparaginyl residues

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Chemical pathways of peptide degradation. VII. Solid state chemical instability of an aspartyl residue in a model hexapeptide

1 reference

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Major degradation products of basic fibroblast growth factor: detection of succinimide and iso-aspartate in place of aspartate

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Evidence for a common intermediate in insulin deamidation and covalent dimer formation: effects of pH and aniline trapping in dilute acidic solutions.

1 reference

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Chemical stability of insulin. 2. Formation of higher molecular weight transformation products during storage of pharmaceutical preparations

1 reference

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7 January 2021

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Moisture-induced aggregation of lyophilized insulin

1 reference

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Aggregates formed during storage of beta-galactosidase in solution and in the freeze-dried state

1 reference

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7 January 2021

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Aggregation of a lyophilized pharmaceutical protein, recombinant human albumin: effect of moisture and stabilization by excipients

1 reference

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7 January 2021

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Solid-state stability of human insulin. I. Mechanism and the effect of water on the kinetics of degradation in lyophiles from pH 2-5 solutions

1 reference

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7 January 2021

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Effects of insulin concentration and self-association on the partitioning of its A-21 cyclic anhydride intermediate to desamido insulin and covalent dimer.

1 reference

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7 January 2021

based on heuristic

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Nature of aggregates formed during storage of freeze-dried ribonuclease A

1 reference

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7 January 2021

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Effect of freezing on aggregation of human growth hormone

1 reference

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7 January 2021

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Stability of interleukin 1 beta (IL-1 beta) in aqueous solution: analytical methods, kinetics, products, and solution formulation implications

1 reference

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7 January 2021

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Antibodies to covalent aggregates of insulin in blood of insulin-using diabetic patients

1 reference

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7 January 2021

based on heuristic

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Stability of protein pharmaceuticals

1 reference

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7 January 2021

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The effects of formulation variables on the stability of freeze-dried human growth hormone

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The relationship between the glass transition temperature and water vapor absorption by poly(vinylpyrrolidone)

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Molecular mobility in mixtures of absorbed water and solid poly(vinylpyrrolidone).

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7 January 2021

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The relationship between the glass transition temperature and the water content of amorphous pharmaceutical solids

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7 January 2021

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Molecular mobility of amorphous pharmaceutical solids below their glass transition temperatures

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7 January 2021

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Beyond water activity: Recent advances based on an alternative approach to the assessment of food quality and safety

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7 January 2021

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The Nature of the Glassy State and the Behavior of Liquids at Low Temperatures

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7 January 2021

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How does residual water affect the solid-state degradation of drugs in the amorphous state?

1 reference

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7 January 2021

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Correlation of IR spectroscopic, heat capacity, diamagnetic susceptibility and enzymatic measurements on lysozyme powder

1 reference

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7 January 2021

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Sequential hydration of dry proteins: a direct difference IR investigation of sequence homologs lysozyme and alpha- lactalbumin

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7 January 2021

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Chemical properties of the functional groups of insulin

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7 January 2021

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Physical stabilization of insulin by glycosylation

1 reference

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On the mass dependence of diffusion within biological membranes and polymers

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Stabilization of chimeric BR96-doxorubicin immunoconjugate

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Long-term preservation of dried phosphofructokinase by sugars and sugar/zinc mixtures

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Stabilization of lyophilized porcine pancreatic elastase

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Physical stability and protein stability of freeze-dried cakes during storage at elevated temperatures

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Identifiers

10.1021/JS9700311

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9188045%20AND%20SRC:MED&resulttype=core&format=json

3 November 2019

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9188045%20AND%20SRC:MED&resulttype=core&format=json

3 November 2019

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