(Q30339034)

19 June 2017

1 reference

title

Molecular recognition: the fragment approach in lead generation. (English)

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19 June 2017

1

Daniela Fattori

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19 June 2017

1 March 2004

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19 June 2017

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19 June 2017

9

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19 June 2017

229-238

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19 June 2017

5

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Enthalpy of hydrogen bond formation in a protein-ligand binding reaction

19 June 2017

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2803%2903007-1

7 January 2021

Energetic and entropic factors determining binding affinity in protein-ligand complexes

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2803%2903007-1

7 January 2021

Attractive intramolecular edge-to-face aromatic interactions in flexible organic molecules

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2803%2903007-1

7 January 2021

Aromatic rings act as hydrogen bond acceptors

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2803%2903007-1

7 January 2021

Implications of protein flexibility for drug discovery

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2803%2903007-1

7 January 2021

The additivity of substrate fragments in enzyme-ligand binding

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2803%2903007-1

7 January 2021

Increasing binding constants of ligands to carbonic anhydrase by using "greasy tails".

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2803%2903007-1

7 January 2021

A Common Mechanism Underlying Promiscuous Inhibitors from Virtual and High-Throughput Screening

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2803%2903007-1

7 January 2021

Development of a virtual screening method for identification of "frequent hitters" in compound libraries

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2803%2903007-1

7 January 2021

Nonleadlikeness and leadlikeness in biochemical screening

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2803%2903007-1

7 January 2021

Molecular complexity and its impact on the probability of finding leads for drug discovery

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2803%2903007-1

7 January 2021

Functional group contributions to drug-receptor interactions.

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2803%2903007-1

7 January 2021

Unraveling principles of lead discovery: from unfrustrated energy landscapes to novel molecular anchors.

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2803%2903007-1

7 January 2021

The properties of known drugs. 1. Molecular frameworks

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2803%2903007-1

7 January 2021

RECAP--retrosynthetic combinatorial analysis procedure: a powerful new technique for identifying privileged molecular fragments with useful applications in combinatorial chemistry

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2803%2903007-1

7 January 2021

Methods for drug discovery: development of potent, selective, orally effective cholecystokinin antagonists

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2803%2903007-1

7 January 2021

2002 Alfred Burger Award Address in Medicinal Chemistry. Natural products and design: interrelated approaches in drug discovery

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2803%2903007-1

7 January 2021

Design and biological activities of L-163,191 (MK-0677): a potent, orally active growth hormone secretagogue

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2803%2903007-1

7 January 2021

Synthesis and biological activities of potent peptidomimetics selective for somatostatin receptor subtype 2

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2803%2903007-1

7 January 2021

Design and pharmacology of N-[(3R)-1,2,3,4-tetrahydroisoquinolinium- 3-ylcarbonyl]-(1R)-1-(4-chlorobenzyl)- 2-[4-cyclohexyl-4-(1H-1,2,4-triazol- 1-ylmethyl)piperidin-1-yl]-2-oxoethylamine (1), a potent, selective, melanocortin subtype-4 receptor ago

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2803%2903007-1

7 January 2021

Peptidomimetics derived from natural products

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2803%2903007-1

7 January 2021

Molecular Recognition of Protein−Ligand Complexes: Applications to Drug Design

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2803%2903007-1

7 January 2021

Modulation of protein-protein interactions with small organic molecules

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2803%2903007-1

7 January 2021

Medicinal chemistry of target family-directed masterkeys

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2803%2903007-1

7 January 2021

A specific mechanism of nonspecific inhibition

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2803%2903007-1

7 January 2021

Privileged molecules for protein binding identified from NMR-based screening

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2803%2903007-1

7 January 2021

Chemical microarrays, fragment diversity, label-free imaging by plasmon resonance--a chemical genomics approach

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2803%2903007-1

7 January 2021

Structure-based screening of low-affinity compounds

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2803%2903007-1

7 January 2021

Recent developments in the design of angiotensin-converting enzyme inhibitors

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2803%2903007-1

7 January 2021

Non-peptide fibrinogen receptor antagonists. 1. Discovery and design of exosite inhibitors

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2803%2903007-1

7 January 2021

Small molecule ligands for oxytocin and vasopressin receptors

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2803%2903007-1

7 January 2021

Discovery of heterocyclic ureas as a new class of raf kinase inhibitors: identification of a second generation lead by a combinatorial chemistry approach

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2803%2903007-1

7 January 2021

10.1016/S1359-6446(03)03007-1

Identifiers

DOI

1 reference

19 June 2017

1 reference

PubMed ID

14980541