(Q30358937)

21 August 2017

The Rac1 inhibitor NSC23766 exerts anti-influenza virus properties by affecting the viral polymerase complex activity. (English)

1 reference

N6-[2-[5-(diethylamino)pentan-2-ylamino]-6-methyl-4-pyrimidinyl]-2-methylquinoline-4,6-diamine

21 August 2017

1 reference

ChEBI release 2020-05-28

Stephan Ludwig

5

0 references

author name string

Rüdiger Dierkes

1

1 reference

21 August 2017

Kathrin Warnking

2

1 reference

21 August 2017

Swantje Liedmann

3

1 reference

21 August 2017

Roman Seyer

4

1 reference

21 August 2017

Christina Ehrhardt

6

1 reference

21 August 2017

language of work or name

English

0 references

publication date

11 February 2014

1 reference

21 August 2017

1 reference

21 August 2017

9

1 reference

21 August 2017

2

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21 August 2017

e88520

1 reference

Creative Commons Attribution 4.0 International

21 August 2017

start time

11 February 2014

1 reference

April 2022 Public Data File from Crossref

copyright status

copyrighted

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cites work

The NF-κB inhibitor SC75741 efficiently blocks influenza virus propagation and confers a high barrier for development of viral resistance

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3921225

Targeting the host or the virus: current and novel concepts for antiviral approaches against influenza virus infection

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3921225

African swine fever virus uses macropinocytosis to enter host cells

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3921225

Small molecule inhibitors of the c-Jun N-terminal kinase (JNK) possess antiviral activity against highly pathogenic avian and human pandemic influenza A viruses

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3921225

Small rho GTPases and cholesterol biosynthetic pathway intermediates in African swine fever virus infection.

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3921225

Phosphatidylinositol-3-kinase (PI3K) is activated by influenza virus vRNA via the pathogen pattern receptor Rig-I to promote efficient type I interferon production

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3921225

Antiviral activity of the MEK-inhibitor U0126 against pandemic H1N1v and highly pathogenic avian influenza virus in vitro and in vivo

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3921225

Disruption of virus-host cell interactions and cell signaling pathways as an anti-viral approach against influenza virus infections

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3921225

Dissection of the influenza A virus endocytic routes reveals macropinocytosis as an alternative entry pathway

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3921225

Roles of small GTPase Rac1 in the regulation of actin cytoskeleton during dengue virus infection

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3921225

The nuclear import of the small GTPase Rac1 is mediated by the direct interaction with karyopherin alpha2.

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3921225

Virtual screening approach for the identification of new Rac1 inhibitors

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3921225

A new player in a deadly game: influenza viruses and the PI3K/Akt signalling pathway

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3921225

Phosphoinositide-3 Kinase-Akt Pathway Controls Cellular Entry of Ebola Virus

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3921225

Higher polymerase activity of a human influenza virus enhances activation of the hemagglutinin-induced Raf/MEK/ERK signal cascade.

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3921225

The contributions of microtubule stability and dynamic instability to adenovirus nuclear localization efficiency.

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3921225

Analysis of apoptosis by propidium iodide staining and flow cytometry

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3921225

Rac1 and a GTPase-activating protein, MgcRacGAP, are required for nuclear translocation of STAT transcription factors

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3921225

Rac1 and PAK1 are upstream of IKK-epsilon and TBK-1 in the viral activation of interferon regulatory factor-3.

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3921225

Rational design and characterization of a Rac GTPase-specific small molecule inhibitor

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3921225

Rho GTPases in cell biology

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3921225

The influenza A virus NS1 protein inhibits activation of Jun N-terminal kinase and AP-1 transcription factors

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3921225

Analysis of Relative Gene Expression Data Using Real-Time Quantitative PCR and the 2−ΔΔCT Method

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3921225

Trp(56) of rac1 specifies interaction with a subset of guanine nucleotide exchange factors

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3921225

A DNA transfection system for generation of influenza A virus from eight plasmids

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3921225

Adamantane resistance among influenza A viruses isolated early during the 2005-2006 influenza season in the United States

3 June 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0088520

HIV-1 infects macrophages by exploiting an endocytic route dependent on dynamin, Rac1 and Pak1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0088520

Vaccinia virus uses macropinocytosis and apoptotic mimicry to enter host cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0088520

Influenza virus-induced AP-1-dependent gene expression requires activation of the JNK signaling pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0088520

Novel mechanism of the co-regulation of nuclear transport of SmgGDS and Rac1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0088520

10.1371/JOURNAL.PONE.0088520

21 January 2018

Identifiers

DOI

1 reference

21 August 2017

0 references

1 reference

21 August 2017

PubMed publication ID

24523909

1 reference