(Q30369380)

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Influenza virus M2 protein ion channel activity helps to maintain pandemic 2009 H1N1 virus hemagglutinin fusion competence during transport to the cell surface.

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scholarly article

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Europe PubMed Central

PMC publication ID

12 October 2017

Influenza virus M2 protein ion channel activity helps to maintain pandemic 2009 H1N1 virus hemagglutinin fusion competence during transport to the cell surface. (English)

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Europe PubMed Central

PMC publication ID

12 October 2017

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6

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Wei Wang

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Europe PubMed Central

12 October 2017

PMC publication ID

author name string

Esmeralda Alvarado-Facundo

1

1 reference

Europe PubMed Central

PMC publication ID

12 October 2017

Yamei Gao

2

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Europe PubMed Central

PMC publication ID

12 October 2017

Rosa María Ribas-Aparicio

3

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Europe PubMed Central

PMC publication ID

12 October 2017

Alicia Jiménez-Alberto

4

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Europe PubMed Central

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12 October 2017

Carol D Weiss

5

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Europe PubMed Central

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12 October 2017

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3 December 2014

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Europe PubMed Central

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12 October 2017

Journal of Virology

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Europe PubMed Central

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12 October 2017

89

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Europe PubMed Central

PMC publication ID

12 October 2017

4

1 reference

Europe PubMed Central

PMC publication ID

12 October 2017

1975-1985

1 reference

Europe PubMed Central

PMC publication ID

12 October 2017

The matrix gene segment destabilizes the acid and thermal stability of the hemagglutinin of pandemic live attenuated influenza virus vaccines

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4338904

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Aminoadamantanes with persistent in vitro efficacy against H1N1 (2009) influenza A

1 reference

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Structural Stability of Influenza A(H1N1)pdm09 Virus Hemagglutinins

1 reference

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A single amino acid in the stalk region of the H1N1pdm influenza virus HA protein affects viral fusion, stability and infectivity.

1 reference

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Egg- or cell culture-derived hemagglutinin mutations impair virus stability and antigen content of inactivated influenza vaccines.

1 reference

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Quantitative thin-layer chromatographic method for determination of amantadine hydrochloride

1 reference

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Influenza HA subtypes demonstrate divergent phenotypes for cleavage activation and pH of fusion: implications for host range and adaptation

1 reference

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Neutralizing and protective epitopes of the 2009 pandemic influenza H1N1 hemagglutinin

1 reference

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Pandemic influenza vaccine: characterization of A/California/07/2009 (H1N1) recombinant hemagglutinin protein and insights into H1N1 antigen stability

1 reference

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Airborne transmission of influenza A/H5N1 virus between ferrets

1 reference

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Experimental adaptation of an influenza H5 HA confers respiratory droplet transmission to a reassortant H5 HA/H1N1 virus in ferrets

1 reference

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Enhanced growth of influenza vaccine seed viruses in vero cells mediated by broadening the optimal pH range for virus membrane fusion

1 reference

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Selection with a peptide fusion inhibitor corresponding to the first heptad repeat of HIV-1 gp41 identifies two genetic pathways conferring cross-resistance to peptide fusion inhibitors corresponding to the first and second heptad repeats (HR1 and H

1 reference

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Cross-neutralizing antibodies to pandemic 2009 H1N1 and recent seasonal H1N1 influenza A strains influenced by a mutation in hemagglutinin subunit 2.

1 reference

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Single HA2 mutation increases the infectivity and immunogenicity of a live attenuated H5N1 intranasal influenza vaccine candidate lacking NS1.

1 reference

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Mutations affecting the stability of the haemagglutinin molecule impair the immunogenicity of live attenuated H3N2 intranasal influenza vaccine candidates lacking NS1.

1 reference

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Structural Characterization of an Early Fusion Intermediate of Influenza Virus Hemagglutinin

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4338904

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Influenza virus assembly and budding

1 reference

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Antigenic stability of H1N1 pandemic vaccines correlates with vaccine strain

1 reference

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A mutation in the receptor binding site enhances infectivity of 2009 H1N1 influenza hemagglutinin pseudotypes without changing antigenicity.

1 reference

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3 June 2018

Influenza virus M2 protein mediates ESCRT-independent membrane scission

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4338904

3 June 2018

Structure and mechanism of proton transport through the transmembrane tetrameric M2 protein bundle of the influenza A virus

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4338904

3 June 2018

Resistance characteristics of influenza to amino-adamantyls

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4338904

3 June 2018

Cleavage of influenza virus hemagglutinin by airway proteases TMPRSS2 and HAT differs in subcellular localization and susceptibility to protease inhibitors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4338904

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Influenza virus m2 ion channel protein is necessary for filamentous virion formation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4338904

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Novel inhibitors of influenza virus fusion: structure-activity relationship and interaction with the viral hemagglutinin

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4338904

3 June 2018

Functional studies and modeling of pore-lining residue mutants of the influenza a virus M2 ion channel

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4338904

3 June 2018

The pH of activation of the hemagglutinin protein regulates H5N1 influenza virus pathogenicity and transmissibility in ducks.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4338904

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Oseltamivir- and amantadine-resistant influenza viruses A (H1N1).

1 reference

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Influenza virus morphogenesis and budding

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4338904

3 June 2018

Amino acid residues in the fusion peptide pocket regulate the pH of activation of the H5N1 influenza virus hemagglutinin protein.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4338904

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Establishment of retroviral pseudotypes with influenza hemagglutinins from H1, H3, and H5 subtypes for sensitive and specific detection of neutralizing antibodies

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4338904

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The influenza virus M2 protein cytoplasmic tail interacts with the M1 protein and influences virus assembly at the site of virus budding

1 reference

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Functional studies indicate amantadine binds to the pore of the influenza A virus M2 proton-selective ion channel

1 reference

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Adamantane resistance in influenza A(H1) viruses increased in 2007 in South East Asia but decreased in Australia and some other countries.

1 reference

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The interplay of functional tuning, drug resistance, and thermodynamic stability in the evolution of the M2 proton channel from the influenza A virus

1 reference

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Structural basis for the function and inhibition of an influenza virus proton channel

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4338904

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Structure and mechanism of the M2 proton channel of influenza A virus

1 reference

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Surveillance of resistance to adamantanes among influenza A(H3N2) and A(H1N1) viruses isolated worldwide

1 reference

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The cytoplasmic tail of the influenza A virus M2 protein plays a role in viral assembly

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4338904

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Influenza M2 envelope protein augments avian influenza hemagglutinin pseudotyping of lentiviral vectors

1 reference

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1 reference

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Cell signaling through the protein kinases cAMP-dependent protein kinase, protein kinase Cepsilon, and RAF-1 regulates amphotropic murine leukemia virus envelope protein-induced syncytium formation.

1 reference

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Generation and characterization of recombinant influenza A (H1N1) viruses harboring amantadine resistance mutations

1 reference

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Alpha-complementation assay for HIV envelope glycoprotein-mediated fusion

1 reference

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1 reference

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Restrictions to the adaptation of influenza a virus h5 hemagglutinin to the human host.

1 reference

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Frequency of Amantadine-Resistant Influenza A Viruses during Two Seasons Featuring Cocirculation of H1N1 and H3N2

1 reference

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Receptor binding and membrane fusion in virus entry: the influenza hemagglutinin

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4338904

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Influenza hemagglutinin is spring-loaded by a metastable native conformation

1 reference

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Multiply attenuated lentiviral vector achieves efficient gene delivery in vivo

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1 reference

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1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4338904

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The ion channel activity of the influenza virus M2 protein affects transport through the Golgi apparatus

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4338904

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In vivo gene delivery and stable transduction of nondividing cells by a lentiviral vector

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Electron microscopy of antibody complexes of influenza virus haemagglutinin in the fusion pH conformation

1 reference

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Ion channel activity of influenza A virus M2 protein: characterization of the amantadine block

1 reference

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Influenza A virus M2 ion channel protein: a structure-function analysis

1 reference

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Influenza virus M2 protein ion channel activity stabilizes the native form of fowl plague virus hemagglutinin during intracellular transport

1 reference

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Changes in the conformation of influenza virus hemagglutinin at the pH optimum of virus-mediated membrane fusion

1 reference

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Single amino acid substitutions in influenza haemagglutinin change receptor binding specificity

1 reference

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The influenza hemagglutinin precursor as an acid-sensitive probe of the biosynthetic pathway

1 reference

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Amantadine selection of a mutant influenza virus containing an acid-stable hemagglutinin glycoprotein: evidence for virus-specific regulation of the pH of glycoprotein transport vesicles

1 reference

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Evidence that the amantadine-induced, M2-mediated conversion of influenza A virus hemagglutinin to the low pH conformation occurs in an acidic trans Golgi compartment

1 reference

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Maturation of influenza A virus hemagglutinin--estimates of the pH encountered during transport and its regulation by the M2 protein

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1 reference

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1 reference

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Changes in the morphology of influenza particles induced at low pH

1 reference

https://pubmed.ncbi.nlm.nih.gov/25473053

12 December 2020

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10.1128/JVI.03253-14

1 reference

Europe PubMed Central

PMC publication ID

12 October 2017

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

12 October 2017

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

12 October 2017

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